KEGG   ENZYME: 4.1.1.53Help
Entry
EC 4.1.1.53                 Enzyme                                 

Name
phenylalanine decarboxylase;
L-phenylalanine decarboxylase;
aromatic L-amino acid decarboxylase;
L-phenylalanine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-phenylalanine carboxy-lyase (phenylethylamine-forming)
Reaction(IUBMB)
L-phenylalanine = phenylethylamine + CO2 [RN:R00699]
Reaction(KEGG)
Substrate
L-phenylalanine [CPD:C00079]
Product
phenylethylamine [CPD:C05332];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. Also acts on tyrosine and other aromatic amino acids.
History
EC 4.1.1.53 created 1972
Pathway
ec00360  Phenylalanine metabolism
Orthology
K22427  phenylalanine decarboxylase
Genes
SLY: 101248029 101248320 101248599 101249664 101263045 101264847 101265155 101265461 101265757 101268488 544085(hdc) 778254(AADC1A) 778255(AADC1B) 778256(AADC2)
SPEN: 107026800 107026802 107027073 107027079 107027080 107027236 107027252 107027311 107027331 107027355 107027771 107027995 107028163
SOT: 102579202 102579840 102580376 102581292 102581308 102581623 102581954 102582616 102591703 102591875 102592044
CANN: 107845032 107848433 107848444 107854627 107854628 107862110 107879725
NTA: 107760316(hdc) 107768931 107789682 107795329 107800126 107800924 107804556 107809914 107812155
NSY: 104220279 104224399 104228428 104237302
NTO: 104095303 104095606 104096073 104097306 104112462 104113710
INI: 109171916
Taxonomy
Reference
1  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J Biol Chem 237:89-93 (1962)
Reference
2  [PMID:6034195]
  Authors
Schulz AR, Oliner L.
  Title
The possible role of thyroid aromatic amino acid decarboxylase in thyroxine biosynthesis.
  Journal
Life Sci 6:873-80 (1967)
DOI:10.1016/0024-3205(67)90291-3
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.53
IUBMB Enzyme Nomenclature: 4.1.1.53
ExPASy - ENZYME nomenclature database: 4.1.1.53
BRENDA, the Enzyme Database: 4.1.1.53
CAS: 9075-72-3

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