KEGG   ENZYME: 4.1.1.6Help
Entry
EC 4.1.1.6                  Enzyme                                 

Name
aconitate decarboxylase;
cis-aconitic decarboxylase;
CAD;
cis-aconitate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
cis-aconitate carboxy-lyase (itaconate-forming)
Reaction(IUBMB)
cis-aconitate = itaconate + CO2 [RN:R02243]
Reaction(KEGG)
Substrate
cis-aconitate [CPD:C00417]
Product
itaconate [CPD:C00490];
CO2 [CPD:C00011]
History
EC 4.1.1.6 created 1961
Pathway
ec00660  C5-Branched dibasic acid metabolism
Orthology
K17724  aconitate decarboxylase
Genes
HSA: 730249(ACOD1)
PTR: 452753(ACOD1)
PPS: 100991677(ACOD1)
GGO: 101139986(ACOD1)
PON: 100453492(ACOD1)
NLE: 100580880(ACOD1)
MCC: 695991(ACOD1)
MCF: 102125305(ACOD1)
CSAB: 103214594(ACOD1)
RRO: 104671179(ACOD1)
RBB: 108516640(ACOD1)
CJC: 100406137(ACOD1)
SBQ: 101037923(IRG1)
MMU: 16365(Acod1)
RNO: 306127(Acod1)
CGE: 100764165(Acod1)
NGI: 103724871(Acod1)
HGL: 101714481(Acod1)
CCAN: 109696343(Acod1)
OCU: 100343808(ACOD1)
TUP: 102484215(ACOD1)
CFA: 485496(ACOD1)
AML: 100469289(ACOD1)
UMR: 103659173(ACOD1)
ORO: 101378779(IRG1)
FCA: 101088973(ACOD1)
PTG: 102971647(ACOD1)
AJU: 106965754(ACOD1)
BTA: 107131195(ACOD1)
BOM: 102266999(ACOD1)
BIU: 109566885(ACOD1)
PHD: 102331628(ACOD1)
CHX: 102183801(ACOD1)
OAS: 101102743(IRG1)
SSC: 100524951(ACOD1)
CFR: 102510611(ACOD1)
CDK: 105103146(ACOD1)
BACU: 103015984(ACOD1)
LVE: 103073823(ACOD1)
OOR: 101289258(IRG1)
ECB: 100052594(ACOD1)
EPZ: 103554777(ACOD1)
EAI: 106843087(ACOD1)
MYB: 102253704(ACOD1)
MYD: 102758508(ACOD1)
HAI: 109389065(ACOD1)
RSS: 109450630(ACOD1)
PALE: 102890891(ACOD1)
LAV: 100662839(ACOD1)
TMU: 101345689
MDO: 100012559(ACOD1)
SHR: 100930346(ACOD1)
OAA: 100084560 100088444(ACOD1)
GGA: 418812(ACOD1) 422307(IRG1L)
MGP: 100546964 100548788(ACOD1)
CJO: 107308047(ACOD1) 107312866
APLA: 101794037(ACOD1) 101794721
ACYG: 106043926(IRG1) 106047514
TGU: 100226594 100229143(ACOD1)
GFR: 102032832(ACOD1) 102041070
FAB: 101810292 101810708(ACOD1)
PHI: 102102295(ACOD1) 102107906
PMAJ: 107201919(ACOD1) 107203748
CCAE: 111928603(ACOD1) 111929257
CCW: 104691709 104695876(ACOD1)
FPG: 101916577(ACOD1) 101922011
FCH: 102045907(ACOD1) 102047977
CLV: 102094294(ACOD1) 102098383
EGZ: 104127050(IRG1) 104127973
AAM: 106489846 106491683(ACOD1)
ASN: 102369682(ACOD1) 102377148
AMJ: 102567064(ACOD1) 102576357
PSS: 102460085(ACOD1)
CMY: 102939148 102943113(ACOD1)
CPIC: 101937974 101939682(ACOD1)
ACS: 100561493(acod1) 100567429
PVT: 110073869(ACOD1) 110080151
PBI: 103049799
GJA: 107108495 107120147(ACOD1)
XLA: 108698345 108698346 108698896 108708498(irg1.L) 108708981(irg1.S) 398116(acod1.L)
XTR: 100125311(acod1) 100490060 100490699(irg1)
NPR: 108794354(ACOD1) 108802827
DRE: 562007(irg1l) 795305(acod1)
IPU: 108266835(acod1) 108269388
AMEX: 103038985(acod1)
LCO: 104921461(acod1) 104938224
NCC: 104958621(irg1)
MZE: 101483061(acod1) 101486456
OLA: 101163093 101169074(acod1)
PRET: 103479303(acod1) 108166618
NFU: 107389734(acod1)
CSEM: 103391176 103391931(acod1)
LCF: 108882906 108901242(acod1)
HCQ: 109531250(acod1)
BPEC: 110164034 110170567(acod1)
MALB: 109954119 109965329(acod1)
ELS: 105031338(acod1)
SFM: 108925368 108929979(acod1)
LCM: 102345136(ACOD1) 102354684
CMK: 103177413(acod1)
CRG: 105336296
MYI: 110454406
OBI: 106875446
PIC: PICST_43263(YXE1)
ANI: AN7940.2
ANG: ANI_1_1536084(An09g06220)
PTE: PTT_12667
 » show all
Taxonomy
Reference
1  [PMID:13438855]
  Authors
BENTLEY R, THIESSEN CP.
  Title
Biosynthesis of itaconic acid in Aspergillus terreus.  III.  The properties and reaction mechanism of cis-aconitic acid decarboxylase.
  Journal
J Biol Chem 226:703-20 (1957)
Reference
2  [PMID:23610393]
  Authors
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K
  Title
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
  Journal
Proc Natl Acad Sci U S A 110:7820-5 (2013)
DOI:10.1073/pnas.1218599110
  Sequence
[hsa:730249] [mmu:16365]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.6
IUBMB Enzyme Nomenclature: 4.1.1.6
ExPASy - ENZYME nomenclature database: 4.1.1.6
BRENDA, the Enzyme Database: 4.1.1.6
CAS: 9025-01-8

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