KEGG   ENZYME: 4.1.1.68Help
Entry
EC 4.1.1.68                 Enzyme                                 

Name
5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase;
5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase;
5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase;
5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(3E,5R)-5-carboxy-2-oxohept-3-enedioate carboxy-lyase [(4Z)-2-oxohept-4-enedioate-forming]
Reaction(IUBMB)
(3E,5R)-5-carboxy-2-oxohept-3-enedioate = (4Z)-2-oxohept-4-enedioate + CO2 (overall reaction) [RN:R04133];
(1a) (3E,5R)-5-carboxy-2-oxohept-3-enedioate = (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate + CO2;
(1b) (2Z,4Z)-2-hydroxyhepta-2,4-dienedioate = (4Z)-2-oxohept-4-enedioate
Reaction(KEGG)
R04133;
(other) R04380
Show
Substrate
(3E,5R)-5-carboxy-2-oxohept-3-enedioate;
(2Z,4Z)-2-hydroxyhepta-2,4-dienedioate
Product
(4Z)-2-oxohept-4-enedioate;
CO2 [CPD:C00011];
(2Z,4Z)-2-hydroxyhepta-2,4-dienedioate
Comment
Requires Mg2+ [2,3]. Part of the 4-hydroxyphenylacetate degradation pathway in Escherichia coli.
History
EC 4.1.1.68 created 1984
Pathway
ec00350  Tyrosine metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K05921  5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
Genes
EOJ: ECO26_5557(hpcE)
EOI: ECO111_5214(hpcE)
EOH: ECO103_5136(hpcE)
ECOO: ECRM13514_5608
ECOH: ECRM13516_5322
ECX: EcHS_A4584(hpaG)
ECY: ECSE_4629
ECR: ECIAI1_4575(hpaG)
EUM: ECUMN_4975(hpaG)
ECL: EcolC_3702
EBR: ECB_04230(hpaG)
EBD: ECBD_3666
EKF: KO11_23405(hpaG)
ELW: ECW_m4713(hpaG)
ELL: WFL_22960(hpaG)
EBL: ECD_04230(hpaG)
EBE: B21_04196(ybl228)
EFE: EFER_3062(hpaG)
STY: STY1134(hpaG)
STT: t1818(hpaG)
STM: STM1101(hpaG)
SEO: STM14_1250(hpaG)
SEY: SL1344_1040(hpaG)
SEJ: STMUK_1070(hpaG)
SEB: STM474_1093(hpaG)
SEF: UMN798_1143(hpaG)
SENR: STMDT2_10371(hpaG)
SEND: DT104_10831(hpaG)
SENI: CY43_05625
SEI: SPC_2649(hpaG)
SEC: SCH_1051(hpaG)
SHB: SU5_01732
SENS: Q786_04920
SED: SeD_A1176
SEG: SG0990(hpaG)
SEL: SPUL_1956(hpaG)
SEGA: SPUCDC_1942(hpaG)
SET: SEN0965(hpaG)
SENA: AU38_04980
SENO: AU37_04970
SENV: AU39_04970
SENQ: AU40_05585
SENL: IY59_05070
SEEP: I137_08890
SENB: BN855_10560(hpaG)
SENE: IA1_05420
SBG: SBG_0947(hpaG)
SBZ: A464_1041
SFL: SF4384(hpaG)
SFX: S4654(hpaG)
SFV: SFV_4384(hpaG)
SFE: SFxv_4778
SFN: SFy_6292
SFS: SFyv_6362
SFT: NCTC1_04760(hpaG)
SSN: SSON_4499(hpaG)
SBO: SBO_4412(hpaG)
SBC: SbBS512_E4890(hpaG)
ENC: ECL_00758
ECLO: ENC_44720
EEC: EcWSU1_00557(hpaG)
ECLX: LI66_03060
ECLY: LI62_03530
ECLZ: LI64_03035
KPN: KPN_04788(hpaG) KPN_04789(hpaG)
KPU: KP1_0742(hpaG2) KP1_0743(hpaG1)
KPR: KPR_0867(hpaG2) KPR_0868(hpaG)
KPX: PMK1_02247(hpcE_1) PMK1_02248(hpcE_2)
KPNK: BN49_4405(hpaG) BN49_4406(hpaG2)
EBT: EBL_c33950(hpcE) EBL_c33960(hpaG)
EBF: D782_3919
YPW: CH59_3405(hpaG) CH59_3406(hpaG)
YPJ: CH55_916(hpaG) CH55_917(hpaG)
YPV: BZ15_1787(hpaG) BZ15_1788(hpaG)
YPL: CH46_3361(hpaG) CH46_3362(hpaG)
YPS: YPTB1637(hpaG) YPTB1638
YPO: BZ17_864(hpaG) BZ17_865(hpaG)
YPI: YpsIP31758_2364(hpaG2) YpsIP31758_2365(hpaG1)
YPQ: DJ40_585(hpaG) DJ40_586(hpaG)
YPU: BZ21_987(hpaG) BZ21_988(hpaG)
YPR: BZ20_337(hpaG) BZ20_338(hpaG)
YPC: BZ23_1265(hpaG) BZ23_1266(hpaG)
YPF: BZ19_1064(hpaG) BZ19_1065(hpaG)
SRL: SOD_c04930(hpaG1) SOD_c04940(hpaG)
SPLY: Q5A_002595(hpcE_1) Q5A_002600(hpcE_2)
SMAR: SM39_4958(hpcE1) SM39_4959(hpcE2)
SMAC: SMDB11_4701(hpcE1) SMDB11_4702(hpcE2)
PLU: plu0989(hpaG2) plu0990(hpaG1)
PAY: PAU_00932(hpaG2) PAU_00933(hpaG1)
XBV: XBW1_1478(hpaG) XBW1_1479
XDO: XDD1_1025(hpaG2) XDD1_1026(hpaG1)
PSX: DR96_1982(hpaG) DR96_1983(hpaG)
PRG: RB151_008130(hpcE_1) RB151_008140(hpcE_2)
PHEI: NCTC12003_00826(hpcE_1) NCTC12003_00827(hpcE_2)
ETE: ETEE_3251(hpaG) ETEE_3252(hpaG)
PMU: PM1528(hpaG_1) PM1529(hpaG_2)
PMV: PMCN06_1795(hpaG1) PMCN06_1796(hpaG2)
PMP: Pmu_17950(hpaG1) Pmu_17960(hpaG2)
PMUL: DR93_377(hpaG) DR93_378(hpaG)
VVY: VV1584
PAEV: N297_4253(hpaG) N297_4254(hpaG)
PAEI: N296_4253(hpaG) N296_4254(hpaG)
PAU: PA14_10640(hpaG2) PA14_10650(hpaG1)
PNC: NCGM2_5322(hpaG1) NCGM2_5323(hpaG2)
PAEB: NCGM1900_0838(hpaG2) NCGM1900_0839(hpaG1)
PAEC: M802_4251(hpaG) M802_4252(hpaG)
PAEO: M801_4119(hpaG) M801_4120(hpaG)
PRE: PCA10_16340(hpaG2) PCA10_16350(hpaG1)
PCQ: PcP3B5_43380(hpcE_1) PcP3B5_43390(hpcE_2)
PPUN: PP4_18990(hpaG2) PP4_19000(hpaG1)
PFL: PFL_3370(hpaG_1) PFL_3371(hpaG_2)
PPRC: PFLCHA0_c34000(hpaG1) PFLCHA0_c34010(hpaG2)
PPRO: PPC_3394(hpaG_1) PPC_3395
PFC: PflA506_3394(hpaG_1) PflA506_3395(hpaG_2)
PEN: PSEEN3092(hpaG-1) PSEEN3093(hpaG-2)
PKC: PKB_2458(hpaG) PKB_2459
PSEC: CCOS191_2707(hpaG1) CCOS191_2708(hpaG2)
PSOS: POS17_3351(hpaG_1) POS17_3352
BMAL: DM55_4408(hpaG) DM55_4409(hpaG)
BMAE: DM78_3450(hpaG) DM78_3451(hpaG)
BMAQ: DM76_3358(hpaG) DM76_3359(hpaG)
BMAF: DM51_4808(hpaG) DM51_4809(hpaG)
BMAZ: BM44_4561(hpaG) BM44_4562(hpaG)
BMAB: BM45_3686(hpaG) BM45_3687(hpaG)
BPSE: BDL_3923(hpaG) BDL_3924(hpaG)
BPK: BBK_3797(hpaG) BBK_3798(hpaG)
BPSH: DR55_4657(hpaG) DR55_4658(hpaG)
BPSA: BBU_5349(hpaG) BBU_5350(hpaG)
BPSO: X996_3875(hpaG) X996_3876(hpaG)
BUT: X994_3923(hpaG) X994_3924(hpaG)
BTE: BTH_II1734(hpaG-1) BTH_II1735(hpaG-2)
BTV: BTHA_5720(hpaG) BTHA_5721(hpaG)
BTHE: BTN_4147(hpaG) BTN_4148(hpaG)
BTHM: BTRA_3945(hpaG) BTRA_3946(hpaG)
BTHL: BG87_4478(hpaG) BG87_4479(hpaG)
BOK: DM82_4771(hpaG) DM82_4772(hpaG)
BOC: BG90_5821(hpaG) BG90_5822(hpaG)
BVE: AK36_4116(hpaG) AK36_4117
BCJ: BCAM1366(hpaG) BCAM1367(hpaG')
BCEN: DM39_3638(hpaG) DM39_3639(hpaG)
BCEW: DM40_4255(hpaG) DM40_4256(hpaG)
BCEO: I35_5218(hpaG) I35_5219(hpaG')
BMK: DM80_3536(hpaG) DM80_3537(hpaG)
BMUL: NP80_4258(hpaG) NP80_4259(hpaG)
BCED: DM42_3720(hpaG) DM42_3721(hpaG)
BDL: AK34_4141(hpaG) AK34_4142(hpaG)
BUB: BW23_5043(hpaG) BW23_5044(hpaG)
BUK: MYA_4420
BUL: BW21_5182(hpaG) BW21_5183(hpaG)
BXB: DR64_7330 DR64_7331(hpaG)
BFN: OI25_4430 OI25_4431(hpaG)
PPNO: DA70_17770
PPNM: LV28_13025
PPUL: RO07_06985
PSPU: NA29_02875
PAPI: SG18_07385
HYF: DTO96_101731(hpcE_1) DTO96_101732(hpcE_2)
BPAR: BN117_0692(hpaG) BN117_0693
BBR: BB0734(hpaG) BB0735
BAV: BAV1264(hpaG') BAV1265(hpaG)
AXX: ERS451415_03956(hpcE_1) ERS451415_03957(hpcE_2)
AMIM: MIM_c17570(hpaG1) MIM_c17580(hpaG2)
AAA: Acav_3015
LIM: L103DPR2_00424(hpcE_1) L103DPR2_00425(hpcE_2)
LIH: L63ED372_02764(hpcE_1) L63ED372_02765(hpcE_2)
GGH: GHH_c31040(hpaG1) GHH_c31050(hpaG2)
ANM: GFC28_1566(hpaG) GFC28_1567(hpaG)
AAMY: GFC30_1750
ANL: GFC29_61(hpaG) GFC29_62(hpaG)
HHD: HBHAL_2376(hpaG1) HBHAL_2377(hpaG2)
VPN: A21D_03940(hpcE_1) A21D_03941(hpcE_2)
ASOC: CB4_02466(hpcE_2) CB4_02467(hpcE_3)
AAC: Aaci_0337
AAD: TC41_0457(hpaG)
BTS: Btus_1575
TMR: Tmar_1820
SAY: TPY_2464(hpaG)
SCB: SCAB_9721
AMIN: AUMI_10090
AUW: AURUGA1_01409(hpcE)
SRO: Sros_7504
STI: Sthe_2803
DRA: DR_A0226
DGE: Dgeo_2413
TRA: Trad_1892
TTH: TT_C0592
TTJ: TTHA0958
TSC: TSC_c10430(hpaG)
TAQ: TO73_1004
MRB: Mrub_1334
 » show all
Taxonomy
Reference
1  [PMID:7026235]
  Authors
Garrido-Peritierra A, Cooper RA
  Title
Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
  Journal
Eur J Biochem 117:581-4 (1981)
DOI:10.1111/j.1432-1033.1981.tb06377.x
Reference
2
  Authors
Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P.
  Title
Characterization of a dienol intermediate in the 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase reaction.
  Journal
J Am Chem Soc 114:11001-11003 (1992)
Reference
3
  Authors
Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P.
  Title
Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications.
  Journal
J Am Chem Soc 117:8719-8726 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.68
IUBMB Enzyme Nomenclature: 4.1.1.68
ExPASy - ENZYME nomenclature database: 4.1.1.68
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.68
BRENDA, the Enzyme Database: 4.1.1.68

DBGET integrated database retrieval system