KEGG   ENZYME: 4.1.1.70Help
Entry
EC 4.1.1.70                 Enzyme                                 

Name
glutaconyl-CoA decarboxylase;
glutaconyl coenzyme A decarboxylase;
pent-2-enoyl-CoA carboxy-lyase;
4-carboxybut-2-enoyl-CoA carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)
Reaction(IUBMB)
4-carboxybut-2-enoyl-CoA = but-2-enoyl-CoA + CO2 [RN:R03028]
Reaction(KEGG)
Substrate
4-carboxybut-2-enoyl-CoA [CPD:C02411]
Product
but-2-enoyl-CoA [CPD:C00877];
CO2 [CPD:C00011]
Comment
The enzyme from Acidaminococcus fermentans is a biotinyl-protein, requires Na+, and acts as a sodium pump. Prior to the Na+-dependent decarboxylation, the carboxylate is transferred to biotin in a Na+-independent manner. The conserved lysine, to which biotin forms an amide bond, is located 34 amino acids before the C-terminus, flanked on both sides by two methionine residues, which are conserved in every biotin-dependent enzyme.
History
EC 4.1.1.70 created 1986, modified 2003
Pathway
ec00362  Benzoate degradation
ec00650  Butanoate metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K01615  glutaconyl-CoA decarboxylase
Genes
GBM: Gbem_1453(gcdA)
GEO: Geob_0238(gcdA)
GEM: GM21_2800
DML: Dmul_25060(gcdA)
DAT: HRM2_38510(gcdA1) HRM2_38640(gcdA2)
DTO: TOL2_C38230
SAT: SYN_00481
DTI: Desti_2254 Desti_2615
DBR: Deba_2446
CSO: CLS_16270
FAA: HMPREF0389_01471(gcdA)
OVA: OBV_10900
BPRS: CK3_23950
PED: ING2D1G_1422(gcdA)
MHG: MHY_07190
PFT: JBW_01700
FNU: FN0204
 » show all
Taxonomy
Reference
1  [PMID:6628393]
  Authors
Buckel W, Semmler R.
  Title
Purification, characterisation and reconstitution of glutaconyl-CoA decarboxylase, a biotin-dependent sodium pump from anaerobic bacteria.
  Journal
Eur J Biochem 136:427-34 (1983)
DOI:10.1111/j.1432-1033.1983.tb07760.x
Reference
2  [PMID:11248185]
  Authors
Buckel W.
  Title
Sodium ion-translocating decarboxylases.
  Journal
Biochim Biophys Acta 1505:15-27 (2001)
DOI:10.1016/S0005-2728(00)00273-5
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.70
IUBMB Enzyme Nomenclature: 4.1.1.70
ExPASy - ENZYME nomenclature database: 4.1.1.70
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.70
BRENDA, the Enzyme Database: 4.1.1.70
CAS: 84399-93-9

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