KEGG   ENZYME: 4.1.1.72Help
Entry
EC 4.1.1.72                 Enzyme                                 

Name
branched-chain-2-oxoacid decarboxylase;
branched-chain oxo acid decarboxylase;
branched-chain alpha-keto acid decarboxylase;
branched-chain keto acid decarboxylase;
BCKA;
(3S)-3-methyl-2-oxopentanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
(3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
Reaction(IUBMB)
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO2 [RN:R03894]
Reaction(KEGG)
Substrate
(3S)-3-methyl-2-oxopentanoate [CPD:C00671]
Product
2-methylbutanal [CPD:C02223];
CO2 [CPD:C00011]
Comment
Acts on a number of 2-oxo acids, with a high affinity towards branched-chain substrates. The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for the biosynthesis of branched-chain fatty acids.
History
EC 4.1.1.72 created 1990
Reference
1  [PMID:3142877]
  Authors
Oku H, Kaneda T.
  Title
Biosynthesis of branched-chain fatty acids in Bacillus subtilis. A decarboxylase is essential for branched-chain fatty acid synthetase.
  Journal
J Biol Chem 263:18386-96 (1988)
Reference
2  [PMID:15358422]
  Authors
de la Plaza M, Fernandez de Palencia P, Pelaez C, Requena T
  Title
Biochemical and molecular characterization of alpha-ketoisovalerate decarboxylase, an enzyme involved in the formation of aldehydes from amino acids  by Lactococcus lactis.
  Journal
FEMS Microbiol Lett 238:367-74 (2004)
DOI:10.1016/j.femsle.2004.07.057
Reference
3  [PMID:15640202]
  Authors
Smit BA, van Hylckama Vlieg JE, Engels WJ, Meijer L, Wouters JT, Smit G
  Title
Identification, cloning, and characterization of a Lactococcus lactis branched-chain alpha-keto acid decarboxylase involved in flavor formation.
  Journal
Appl Environ Microbiol 71:303-11 (2005)
DOI:10.1128/AEM.71.1.303-311.2005
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.72
IUBMB Enzyme Nomenclature: 4.1.1.72
ExPASy - ENZYME nomenclature database: 4.1.1.72
BRENDA, the Enzyme Database: 4.1.1.72
CAS: 63653-19-0

DBGET integrated database retrieval system