KEGG   ENZYME: 4.1.1.75Help
Entry
EC 4.1.1.75                 Enzyme                                 

Name
5-guanidino-2-oxopentanoate decarboxylase;
alpha-ketoarginine decarboxylase;
2-oxo-5-guanidinopentanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming)
Reaction(IUBMB)
5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2 [RN:R03178]
Reaction(KEGG)
Substrate
5-guanidino-2-oxopentanoate [CPD:C03771]
Product
4-guanidinobutanal [CPD:C02647];
CO2 [CPD:C00011]
Comment
Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.
History
EC 4.1.1.75 created 1999
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12253  5-guanidino-2-oxopentanoate decarboxylase
Genes
PAE: PA4977(aruI)
PAEV: N297_5149
PAEI: N296_5149
PAU: PA14_65795
PAP: PSPA7_5710
PAG: PLES_53651(aruI)
PNC: NCGM2_0541
PAEB: NCGM1900_5725
PDK: PADK2_26375
PSG: G655_26230
PAEP: PA1S_26995
PAEM: U769_27260
PAEL: T223_27455
PAEG: AI22_07000
PAEC: M802_5147
PAEO: M801_5014
PCQ: PcP3B5_02220(aruI_1)
PPU: PP_3723(aruI)
PPF: Pput_2040
PPT: PPS_3191
PPI: YSA_09434
PPX: T1E_1730
PPUH: B479_15835
PPUT: L483_19375
PPUN: PP4_20990
PPUD: DW66_3462
PMON: X969_15345
PMOT: X970_14990
PFL: PFL_2714
PPRC: PFLCHA0_c27750(ilvB1)
PPRO: PPC_2761(aruI)
PMAN: OU5_1976
PKC: PKB_0123
PSEM: TO66_13285
PSOS: POS17_2710(aruI)
PANR: A7J50_2200
PSET: THL1_3998
MICC: AUP74_02851(aruI_1)
SHZ: shn_17240
OTM: OSB_09640(aruI)
SPSE: SULPSESMR1_00851(aruI)
RMM: ROSMUCSMR3_00989(aruI)
AHT: ANTHELSMS3_04191(aruI)
MOX: DAMO_0156
 » show all
Taxonomy
Reference
1  [PMID:237915]
  Authors
Vanderbilt AS, Gaby NS, Rodwell VW.
  Title
Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida.
  Journal
J Biol Chem 250:5322-9 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.75
IUBMB Enzyme Nomenclature: 4.1.1.75
ExPASy - ENZYME nomenclature database: 4.1.1.75
BRENDA, the Enzyme Database: 4.1.1.75
CAS: 56831-67-5

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