KEGG   ENZYME: 4.1.1.80Help
Entry
EC 4.1.1.80                 Enzyme                                 

Name
4-hydroxyphenylpyruvate decarboxylase;
4-hydroxyphenylpyruvate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)
Reaction(IUBMB)
4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2 [RN:R03341]
Reaction(KEGG)
Substrate
4-hydroxyphenylpyruvate [CPD:C01179]
Product
4-hydroxyphenylacetaldehyde [CPD:C03765];
CO2 [CPD:C00011]
Comment
Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton.
History
EC 4.1.1.80 created 2002
Pathway
ec00350  Tyrosine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Rueffer, M. and Zenk, M.H.
  Title
Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation.
  Journal
Z Naturforsch C: Biosci 42:319-332 (1987)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.80
IUBMB Enzyme Nomenclature: 4.1.1.80
ExPASy - ENZYME nomenclature database: 4.1.1.80
BRENDA, the Enzyme Database: 4.1.1.80
CAS: 109300-96-1

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