KEGG   ENZYME: 4.1.1.81Help
Entry
EC 4.1.1.81                 Enzyme                                 

Name
threonine-phosphate decarboxylase;
L-threonine-O-3-phosphate decarboxylase;
CobD;
L-threonine-O-3-phosphate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-threonine-O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]
Reaction(IUBMB)
L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO2 [RN:R06530]
Reaction(KEGG)
Substrate
L-threonine O-3-phosphate [CPD:C12147]
Product
(R)-1-aminopropan-2-yl phosphate [CPD:C04122];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. This enzyme is unable to decarboxylate the D-isomer of threonine O-3-phosphate. The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, adenosylcobinamide-phosphate synthase, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.
History
EC 4.1.1.81 created 2004
Pathway
ec00860  Porphyrin and chlorophyll metabolism
Orthology
K04720  threonine-phosphate decarboxylase
Genes
STY: STY0695(cobD)
STT: t2223(cobD)
SEX: STBHUCCB_23500
SENT: TY21A_11270
STM: STM0644(cobD)
SEO: STM14_0752(cobD)
SEV: STMMW_07091
SEY: SL1344_0632(cobD)
SEM: STMDT12_C07070(cobD)
SEJ: STMUK_0649(cobD)
SEB: STM474_0665(cobD)
SEF: UMN798_0697(cobD)
SENR: STMDT2_06351(cobD)
SEND: DT104_06731(cobD)
SENI: CY43_03510
SPT: SPA2090(cobD)
SEK: SSPA1942
SEI: SPC_0660
SEC: SCH_0674(cobD)
SEH: SeHA_C0760(cobD)
SHB: SU5_01335
SEW: SeSA_A0804(cobD)
SEA: SeAg_B0687(cobD)
SENS: Q786_03155
SED: SeD_A0747(cobD)
SEL: SPUL_2316(cobD)
SEGA: SPUCDC_2302(cobD)
SET: SEN0613(cobD)
SENA: AU38_03140
SENO: AU37_03135
SENV: AU39_03140
SENQ: AU40_03460
SENL: IY59_03190
SEEP: I137_10565
SENB: BN855_6380(cobD)
SENE: IA1_03375
KPN: KPN_03224(cobD)
KPU: KP1_4493(cobD)
KPP: A79E_0886
KPE: KPK_0891(cobD)
KPR: KPR_1809(cobD)
KPJ: N559_1015
KPX: PMK1_00705(cobD)
KPNU: LI86_05015
KPNK: BN49_0884(cobD1)
KVA: Kvar_0846
KOX: KOX_01550
KOE: A225_4775
CKO: CKO_02518
CRO: ROD_06581(cobD)
CAMA: F384_02840
EBF: D782_3202
YEN: YE2749(cobD)
YEY: Y11_16361
YEW: CH47_2098
YET: CH48_3132
YEE: YE5303_31821(cobD)
YAL: AT01_4014
YFR: AW19_700
YIN: CH53_3348
YKR: CH54_962
YRO: CH64_83
PLU: plu2967(cobD)
PAY: PAU_01635(cobD)
XBO: XBJ1_0854
XBV: XBW1_1556(cobD)
XNE: XNC1_1146
XNM: XNC2_1125
MMK: MU9_1017
ETR: ETAE_1849(cobD)
ETD: ETAF_1668
ETE: ETEE_3896(cobD)
HEL: HELO_1817(cobD)
HAM: HALO2033
HCO: LOKO_03149(cobD)
HBE: BEI_1061(cobD)
TAU: Tola_1705
SUA: Saut_0088
ARC: ABLL_2647
GSK: KN400_2932(cobD)
GME: Gmet_0487(cobD)
GUR: Gura_0043
GBM: Gbem_3537(cobD)
GEO: Geob_0040(cobD)
GEM: GM21_3603
GEB: GM18_0552
PPD: Ppro_0869
DES: DSOUD_0633(cobD)
DEU: DBW_3082
DVM: DvMF_3015
DDE: Dde_1401
DGG: DGI_1341
DML: Dmul_05760(cobD1)
DAL: Dalk_0456
DTO: TOL2_C39890(cobD)
SFU: Sfum_1737
DBR: Deba_1099
BHA: BH1589
BMQ: BMQ_1996(cobD)
BMD: BMD_1952(cobD)
BMH: BMWSH_3284(cobC)
BMEG: BG04_4297
BEO: BEH_16940
BKW: BkAM31D_10680(cobD)
GKA: GK2262
GTN: GTNG_2195
GEA: GARCT_02234(cobD)
AFL: Aflv_1045(cobD)
ANM: GFC28_88
AAMY: GFC30_2464
LSP: Bsph_2443
LMO: lmo1169(cobD)
LMOE: BN418_1372
LMOB: BN419_1370
LMOD: LMON_1162(cobD)
LMOW: AX10_14350
LMOQ: LM6179_1476(cobD)
LMR: LMR479A_1190(cobD)
LMOM: IJ09_04490
LMC: Lm4b_01174(cobD)
LMOG: BN389_11880(cobD)
LMP: MUO_06040
LMOX: AX24_03215
LMH: LMHCC_1481(cobD)
LMQ: LMM7_1175
LML: lmo4a_1152(cobD)
LMS: LMLG_1095
LMOK: CQ02_06010
LIN: cobD
LWE: lwe1127(cobD)
LSG: lse_1047
LIV: LIV_1101(cobD)
PPM: PPSC2_06620(cobD)
PPO: PPM_1253(cobD)
PPOL: X809_07075
PPQ: PPSQR21_013530(hisC)
PPOY: RE92_05265
PSAB: PSAB_08955
PRI: PRIO_1519
PSWU: SY83_08825
ASOC: CB4_00862(cobD)
BTS: Btus_0419
SIV: SSIL_2472
JEO: JMA_30700
PCE: PECL_1404(cobD)
CAC: CA_C1369(hisC)
CAE: SMB_G1392(hisC)
CAY: CEA_G1383(hisC)
CPE: CPE1373
CPF: CPF_1623
CPR: CPR_1365
CTC: CTC_00722(cobD)
CTET: BN906_00759(cobD_3)
CBA: CLB_0956
CBH: CLC_0970
CBY: CLM_1063
CBL: CLK_0353
CBB: CLD_3644
CBI: CLJ_B0966
CBN: CbC4_1385
CBF: CLI_1002
CBM: CBF_0974
CKL: CKL_0714(cobD1)
CKR: CKR_0636
CLJ: CLJU_c32000(cobD1)
CSR: Cspa_c14690(cobD2)
CPAS: Clopa_1208
CPAT: CLPA_c12560(cobD2)
CPAE: CPAST_c12560(cobD2)
CBV: U729_1939
CSQ: CSCA_5057
CLD: CLSPO_c09130(cobD2)
CTYK: CTK_C09360
AOE: Clos_2211
ESU: EUS_20020
RUM: CK1_25910
FPR: FP2_02910
FPA: FPR_29080
BFI: CIY_17480
BHU: bhn_I2356
RIX: RO1_09020
RIM: ROI_20630
COO: CCU_17260
RTO: RTO_06930
CPY: Cphy_1111
CSO: CLS_24000
BPRL: CL2_10260
HSD: SD1D_1933
CPRO: CPRO_04580(cobD)
ERT: EUR_14110
ERA: ERE_28300
PDC: CDIF630_02947(cobD1) CDIF630_03740(cobD2)
EAC: EAL2_808p00930(cobD2)
CST: CLOST_0985(cobD) CLOST_1921(hisC)
STH: STH1925
SLP: Slip_0933
DRM: Dred_2701
DAE: Dtox_3089
PTH: PTH_1314(HisC)
DAU: Daud_1849
SGY: Sgly_2882
HMO: HM1_2404(cobD)
ELM: ELI_0782
EHL: EHLA_0213
AWO: Awo_c30190(cobB)
SAY: TPY_2787(cobD)
CTHM: CFE_1381
BPRS: CK3_32090
TTE: TTE0380(HisC)
THX: Thet_0347
TIT: Thit_0347
TKI: TKV_c03170(cobD2)
MTA: Moth_1104
ADG: Adeg_1466
TPZ: Tph_c05160(cobD2)
TOC: Toce_1422
TTM: Tthe_2258
TSH: Tsac_0060
FMA: FMG_1150
CAD: Curi_c05780(cobB)
VPR: Vpar_0910
VRM: 44547418_00927(cobD)
MED: MELS_1828
SRI: SELR_20690(cobD)
MHG: MHY_16020
PUF: UFO1_2207
PFT: JBW_02348
LPIL: LIP_3519
RXY: Rxyl_0650
RCA: Rcas_0633
CAG: Cagg_1260
IPA: Isop_1084
KST: KSMBR1_0203(cobD)
TDE: TDE2687
TPED: TPE_0828
ABAS: ACPOL_5144
FNU: FN0973
LBA: Lebu_0041
TAI: Taci_0554
TLI: Tlie_0162
SBR: SY1_23840
BFR: BF2490
BVU: BVU_3116
BCEL: BcellWH2_00333(cobD)
PCRE: NCTC12858_00655(cobD)
PDI: BDI_2337
TFO: BFO_1845
PSAC: PSM36_1121
PRU: PRU_2511
DORI: FH5T_00475
MBAS: ALGA_3991
CPI: Cpin_4468
DFE: Dfer_5370
TJE: TJEJU_2885(cobC)
CPC: Cpar_1180
CCH: Cag_1011
CLI: Clim_1067
PVI: Cvib_0815
PPH: Ppha_1265
PAA: Paes_1268
PROC: Ptc2401_01261(cobD)
CTS: Ctha_1274
TTK: TST_1571(cobD)
NDE: NIDE2661(cobD)
NIO: NITINOP_2556(cobD)
NJA: NSJP_3531(cobD)
LFC: LFE_0987
CTHI: THC_0081
FPL: Ferp_2528
GAC: GACE_0308
GAH: GAH_00018
TAC: Ta0021
FAI: FAD_0085
CDIV: CPM_1091
MEAR: Mpt1_c02250(aspC2)
MARC: AR505_1294
MBAR: MSBR2_1555
MBAK: MSBR3_1557
MMA: MM_2060
MMAC: MSMAC_1795
METM: MSMTP_2540
MTHE: MSTHC_1940
MTHR: MSTHT_1352
MHOR: MSHOH_3289
MBU: Mbur_2087(cobD) Mbur_2089(cobD)
MMH: Mmah_0284
MHI: Mhar_2329
MHU: Mhun_0940
MLA: Mlab_0745
MBG: BN140_2225(hisC3)
MEMA: MMAB1_2949(hisC)
MPD: MCP_1952
MEZ: Mtc_1092
RCI: RCIX2655(cobD)
HSL: OE_3259F(cobD)
HHB: Hhub_2917(cobD)
HALH: HTSR_1762(cobD)
HHSR: HSR6_1828(cobD)
HSU: HLASF_0299(cobD1)
HSF: HLASA_0298(cobD1)
HHI: HAH_2443(hisC2)
NPH: NP_5302A(cobD)
NMO: Nmlp_2451(cobD)
HMU: Hmuk_0141
HWA: HQ_1407A(cobD)
HWC: Hqrw_1483(cobD)
HVO: HVO_0591(cobD1)
HME: HFX_0578(hisC1) HFX_0580(cobD)
HTU: Htur_2837
NMG: Nmag_0991(cobD)
NAT: NJ7G_1621
IAG: Igag_0328
VDI: Vdis_0298
VMO: VMUT_1334
ASC: ASAC_0144
ACIA: SE86_01485
NMR: Nmar_1585
NCT: NMSP_0174(aspC_1)
NEV: NTE_03114
TAA: NMY3_03724(cobD)
NCV: NCAV_0144(dapL)
NBV: T478_1309(hisC)
NDV: NDEV_1952
 » show all
Taxonomy
Reference
1  [PMID:11939774]
  Authors
Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I.
  Title
Three-dimensional structure of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica.
  Journal
Biochemistry 41:4798-808 (2002)
DOI:10.1021/bi012111w
Reference
2  [PMID:9446573]
  Authors
Brushaber KR, O'Toole GA, Escalante-Semerena JC
  Title
CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2.
  Journal
J Biol Chem 273:2684-91 (1998)
DOI:10.1074/jbc.273.5.2684
  Sequence
[stm:STM0644]
Reference
3  [PMID:12195810]
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.81
IUBMB Enzyme Nomenclature: 4.1.1.81
ExPASy - ENZYME nomenclature database: 4.1.1.81
BRENDA, the Enzyme Database: 4.1.1.81

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