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Entry
EC 4.1.1.87                 Enzyme                                 

Name
malonyl-S-ACP decarboxylase;
malonyl-S-acyl-carrier protein decarboxylase;
MdcD/MdcE;
MdcD,E
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
malonyl-[acyl-carrier-protein] carboxy-lyase
Reaction(IUBMB)
a malonyl-[acyl-carrier protein] + H+ = an acetyl-[acyl-carrier protein] + CO2 [RN:R09482]
Reaction(KEGG)
Substrate
malonyl-[acyl-carrier protein] [CPD:C01209];
H+ [CPD:C00080]
Product
acetyl-[acyl-carrier protein] [CPD:C03939];
CO2 [CPD:C00011]
Comment
This enzyme comprises the beta and gamma subunits of EC 4.1.1.88 (biotin-independent malonate decarboxylase) but is not present in EC 4.1.1.89 (biotin-dependent malonate decarboxylase). It follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetylated form of the acyl-carrier-protein subunit of malonate decarboxylase [5]. The carboxy group is lost with retention of configuration [3].
History
EC 4.1.1.87 created 2008
Orthology
K13932  malonate decarboxylase beta subunit
K13933  malonate decarboxylase gamma subunit
Genes
SES: SARI_04160 SARI_04161
ENT: Ent638_3775 Ent638_3776
ENC: ECL_04723 ECL_04724
ENO: ECENHK_20505 ECENHK_20510
ECLO: ENC_25580 ENC_25590
EEC: EcWSU1_04147 EcWSU1_04148(accD)
ENL: A3UG_20990 A3UG_20995
ECLG: EC036_40940 EC036_40950
ECLE: ECNIH2_21520 ECNIH2_21525
ECLN: ECNIH4_02085 ECNIH4_02090
KPT: VK055_0942(mdcD) VK055_0943(mdcE)
KPE: KPK_2897(mdcD) KPK_2898(mdcE)
KPX: PMK1_03878 PMK1_03879(accD_2)
CRO: ROD_44601(mdcD) ROD_44611(mdcE)
KGO: CEW81_02100(mdcE)
PVA: Pvag_2971(mdcD) Pvag_2972(mdcE)
XCC: XCC3611(mdcB) XCC3612(mdcC)
XCA: xcc-b100_0591(mdcD) xcc-b100_0592(mdcE)
XCV: XCV0596(mdcD) XCV0597(mdcE)
XAX: XACM_0553(mdcD) XACM_0554(mdcE)
XAC: XAC0562(mdcB) XAC0563(mdcC)
XCI: XCAW_00976(mdcB) XCAW_00977(mdcC)
XPH: XppCFBP6546_08915(XppCFBP6546P_08915) XppCFBP6546_08920(XppCFBP6546P_08920)
PAE: PA0211(mdcD) PA0212(mdcE)
PAEV: N297_217(mdcD) N297_218(mdcE)
PAEI: N296_217(mdcD) N296_218(mdcE)
PAU: PA14_02580(mdcD) PA14_02590(mdcE)
PAP: PSPA7_0295(mdcD) PSPA7_0296(mdcE)
PAG: PLES_02061(mdcD) PLES_02071(mdcE)
PAF: PAM18_0206(mdcD) PAM18_0207(mdcE)
PNC: NCGM2_0215(mdcD) NCGM2_0216(mdcE)
PAEB: NCGM1900_0200(mdcD) NCGM1900_0201(mdcE)
PAEU: BN889_00259(mdcD) BN889_00260(mdcE)
PAEC: M802_216(mdcD) M802_217(mdcE)
PAEO: M801_217(mdcD) M801_218(mdcE)
PRE: PCA10_01840(mdcD) PCA10_01850(mdcE)
PPUN: PP4_23650(mdcD) PP4_23660(mdcE)
PST: PSPTO_5083(mdcE) PSPTO_5084(mdcD)
PSP: PSPPH_0436(mdcD) PSPPH_0437(mdcE)
PFL: PFL_5816(mdcE) PFL_5817(mdcD)
PPRC: PFLCHA0_c57710(mdcE) PFLCHA0_c57720(mdcD)
PFE: PSF113_5517(mdcE) PSF113_5518(mdcD)
PFC: PflA506_5038(mdcE) PflA506_5039(mdcD)
PMAN: OU5_3877(mdcD) OU5_3878(mdcE)
PSA: PST_4116(mdcE) PST_4117(mdcD)
PSZ: PSTAB_4098(mdcE) PSTAB_4099(mdcD)
PSR: PSTAA_4268(mdcE) PSTAA_4269(mdcD)
PPUU: PputUW4_05095(mdcE) PputUW4_05096(mdcD)
ACX: Achr_31790(mdcE) Achr_31800(mdcD)
PAR: Psyc_1143(mdcC) Psyc_1144(mdcB)
ABY: ABAYE2229(mdcE) ABAYE2230(mdcD)
ABB: ABBFA_002062(mdcE) ABBFA_002063(mdcD)
ABAD: ABD1_14250(mdcD) ABD1_14260(mdcE)
ACC: BDGL_000809(mdcD) BDGL_000810(mdcE)
ACI: ACIAD1756(mdcD) ACIAD1757(mdcE)
LPN: lpg2427(mdcB) lpg2428(mdcC)
LPH: LPV_2748(mdcB) LPV_2749(mdcC)
LPO: LPO_2617(mdcB) LPO_2618(mdcC)
LPM: LP6_2455(mdcB) LP6_2456(mdcC)
LPC: LPC_2048(mdcC) LPC_2049(mdcB)
LPA: lpa_03540 lpa_03541(mdcC)
LLO: LLO_2545(mdcE) LLO_2546
LFA: LFA_0133 LFA_0134(mdcE)
PSE: NH8B_2981(mdcB) NH8B_2982(mdcD)
RSC: RCFBP_11830(mdcD) RCFBP_11831(mdcE)
RIN: ACS15_5433(mdcD) ACS15_5434(mdcE)
CNC: CNE_1c16480(mdcD) CNE_1c16490(mdcE)
BMA: BMA3034(mdcC) BMA3035(mdcB)
BMV: BMASAVP1_A1258(mdcB) BMASAVP1_A1259(mdcC)
BML: BMA10229_A0611(mdcC) BMA10229_A0612(mdcB)
BMN: BMA10247_0541(mdcD-3) BMA10247_0542(mdcC)
BMAL: DM55_2720(mdcD) DM55_2721(mdcE)
BMAE: DM78_2263(mdcE) DM78_2264(mdcD)
BMAQ: DM76_2704(mdcD) DM76_2705(mdcE)
BMAF: DM51_2638(mdcE) DM51_2639(mdcD)
BMAZ: BM44_2488(mdcE) BM44_2489(mdcD)
BMAB: BM45_2053(mdcE) BM45_2054(mdcD)
BPR: GBP346_A1487(mdcD) GBP346_A1488(mdcE)
BPSE: BDL_684(mdcE) BDL_685(mdcD)
BPSM: BBQ_2111(mdcE) BBQ_2112(mdcD)
BPSU: BBN_2237(mdcE) BBN_2238(mdcD)
BPSD: BBX_2625(mdcE) BBX_2626(mdcD)
BPK: BBK_188(mdcE) BBK_189(mdcD)
BPSH: DR55_3266(mdcE) DR55_3267(mdcD)
BPSA: BBU_861(mdcE) BBU_862(mdcD)
BPSO: X996_2873(mdcE) X996_2874(mdcD)
BUT: X994_1333(mdcE) X994_1334(mdcD)
BTQ: BTQ_1218(mdcD) BTQ_1219(mdcE)
BTJ: BTJ_1214(mdcE) BTJ_1215(mdcD)
BTZ: BTL_2449(mdcE) BTL_2450(mdcD)
BTD: BTI_2498(mdcE) BTI_2499(mdcD)
BTV: BTHA_2635(mdcE) BTHA_2636(mdcD)
BTHE: BTN_2208(mdcD) BTN_2209(mdcE)
BTHM: BTRA_2806(mdcE) BTRA_2807(mdcD)
BTHL: BG87_2697(mdcE) BG87_2698(mdcD)
BOK: DM82_773(mdcD) DM82_774(mdcE)
BOC: BG90_243(mdcE) BG90_244(mdcD)
BVE: AK36_2676(mdcE) AK36_2677(mdcD)
BCEN: DM39_1149(mdcD) DM39_1150(mdcE)
BCEW: DM40_1925(mdcD) DM40_1926(mdcE)
BMJ: BMULJ_01196(pcc) BMULJ_01197(mdcC)
BMK: DM80_380(mdcE) DM80_381(mdcD)
BMUL: NP80_1359(mdcD) NP80_1360(mdcE)
BCED: DM42_448(mdcE) DM42_449(mdcD)
BDL: AK34_1895(mdcE) AK34_1896(mdcD)
BUB: BW23_467(mdcE) BW23_468(mdcD)
BGU: KS03_2052(mdcD) KS03_2053
BGO: BM43_2651(mdcD) BM43_2652(mdcE)
BUL: BW21_2514(mdcE) BW21_2515(mdcD)
BXB: DR64_7154(mdcD) DR64_7155(mdcE)
BFN: OI25_4299(mdcD) OI25_4300(mdcE)
AFQ: AFA_04485(mdcE) AFA_04490
HAR: HEAR1471(mdcB) HEAR1472(mdcE)
MMS: mma_0106(mdcD1) mma_0107(mdcE1) mma_2560(mdcE2) mma_2561(mdcD2)
JAG: GJA_2733(mdcE) GJA_2734(mdcD)
HSE: Hsero_2681(mdcC) Hsero_2682(accD)
HRB: Hrubri_2767(mdcC) Hrubri_2768(accD)
CFU: CFU_1710(mdcB) CFU_1711(mdcC)
CPRA: CPter91_2201(mdcD) CPter91_2202(mdcE)
OFO: BRW83_1384(madD) BRW83_1385(madC)
AZA: AZKH_1587(mdcD) AZKH_1588(mdcB)
CCRO: CMC5_081250(mdcD) CMC5_081260(mdcE)
BJA: bll0267(mdcE) bll0268(mdcD) bll1274(mdcE) bll1275(mdcD)
BRS: S23_13490(mdcD) S23_13500(mdcE)
OCA: OCAR_6869 OCAR_6870(mdcD)
MEA: Mex_1p0025(mdcD) Mex_1p0026(mdcE)
MDI: METDI0026(mdcD) METDI0027(mdcE)
MOR: MOC_0176(mdcD) MOC_0177(mdcE)
BPF: BpOF4_11985(mdcB2)
BMQ: BMQ_0799(mdcD)
BMD: BMD_0800(mdcD)
BMEG: BG04_3094(mdcD)
BEO: BEH_05665
BKW: BkAM31D_07975(madC)
PPOL: X809_35660
SIV: SSIL_3614
LCR: LCRIS_01569(mdcD)
EFU: HMPREF0351_10355(mdcE)
EFM: M7W_526
ECAS: ECBG_00929
EDU: LIU_13400
 » show all
Taxonomy
Reference
1  [PMID:8620876]
  Authors
Schmid M, Berg M, Hilbi H, Dimroth P
  Title
Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group.
  Journal
Eur J Biochem 237:221-8 (1996)
DOI:10.1111/j.1432-1033.1996.0221n.x
Reference
2  [PMID:10561613]
  Authors
Koo JH, Kim YS
  Title
Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus.
  Journal
Eur J Biochem 266:683-90 (1999)
DOI:10.1046/j.1432-1327.1999.00924.x
Reference
3  [PMID:10496981]
  Authors
Handa S, Koo JH, Kim YS, Floss HG
  Title
Stereochemical course of biotin-independent malonate decarboxylase catalysis.
  Journal
Arch Biochem Biophys 370:93-6 (1999)
DOI:10.1006/abbi.1999.1369
Reference
4  [PMID:12619701]
  Authors
Chohnan S, Akagi K, Takamura Y
  Title
Functions of malonate decarboxylase subunits from Pseudomonas putida.
  Journal
Biosci Biotechnol Biochem 67:214-7 (2003)
DOI:10.1271/bbb.67.214
Reference
5  [PMID:11902724]
  Authors
Dimroth P, Hilbi H
  Title
Enzymic and genetic basis for bacterial growth on malonate.
  Journal
Mol Microbiol 25:3-10 (1997)
DOI:10.1046/j.1365-2958.1997.4611824.x
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.87
IUBMB Enzyme Nomenclature: 4.1.1.87
ExPASy - ENZYME nomenclature database: 4.1.1.87
BRENDA, the Enzyme Database: 4.1.1.87

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