KEGG   ENZYME: 4.1.2.11Help
Entry
EC 4.1.2.11                 Enzyme                                 

Name
hydroxymandelonitrile lyase;
hydroxynitrile lyase;
oxynitrilase;
Sorghum hydroxynitrile lyase;
(S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(S)-4-hydroxymandelonitrile = cyanide + 4-hydroxybenzaldehyde [RN:R02676]
Reaction(KEGG)
R02676;
(other) R01409 R02811
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Substrate
(S)-4-hydroxymandelonitrile [CPD:C03742]
Product
cyanide [CPD:C00177];
4-hydroxybenzaldehyde [CPD:C00633]
Comment
Does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 (mandelonitrile lyase), EC 4.1.2.46 [aliphatic (R)-hydroxynitrile lyase] and EC 4.1.2.47 [(S)-hydroxynitrile ketone-lyase (cyanide forming)].
History
EC 4.1.2.11 created 1965, modified 1999
Pathway
ec00460  Cyanoamino acid metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K08249  hydroxymandelonitrile lyase
Genes
SBI: 110435085 110435343 8066733
SITA: 101776721
Taxonomy
Reference
1
  Authors
Bove, C. and Conn, E.E.
  Title
Metabolism of aromatic compounds in higher plants. II. Purification and properties of the oxynitrilase of Sorghum vulgare.
  Journal
J Biol Chem 236:207-210 (1961)
Reference
2  [PMID:5922969]
  Authors
Seely MK, Criddle RS, Conn EE.
  Title
The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin.
  Journal
J Biol Chem 241:4457-62 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.11
IUBMB Enzyme Nomenclature: 4.1.2.11
ExPASy - ENZYME nomenclature database: 4.1.2.11
BRENDA, the Enzyme Database: 4.1.2.11
CAS: 9075-38-1

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