KEGG   ENZYME: 4.1.2.41Help
Entry
EC 4.1.2.41                 Enzyme                                 

Name
vanillin synthase;
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA [RN:R05773]
Reaction(KEGG)
Substrate
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
Product
vanillin [CPD:C00755];
acetyl-CoA [CPD:C00024]
Comment
Involved, together with EC 4.2.1.101 trans-feruloyl-CoA hydratase, in the production of vanillin from trans-ferulic acid. Vanillin is converted to vanillate by EC 1.2.1.67 vanillin dehydrogenase.
History
EC 4.1.2.41 created 2000
Pathway
ec00360  Phenylalanine metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18383  trans-feruloyl-CoA hydratase / vanillin synthase
Genes
XCC: XCC0810(fadB)
XCB: XC_3420
XCA: xcc-b100_3542(ech4)
XCP: XCR_0990
XCV: XCV0918(paaF)
XAX: XACM_0864(paaF)
XAC: XAC0883(fadB)
XCI: XCAW_03697(caiD)
XCT: J151_01010
XCJ: J158_01007
XOO: XOO3728(fadB)
XOM: XOO3520(XOO3520)
XOP: PXO_04626
XOR: XOC_0934
XAL: XALC_3045
XPH: XppCFBP6546_07095(XppCFBP6546P_07095)
PPU: PP_3358
PPF: Pput_2400
PSB: Psyr_2728
PSYR: N018_13590
PPRO: PPC_3628(paaG)
PFS: PFLU_3300
PSES: PSCI_1563(paaG)
PSEM: TO66_18490
PSOS: POS17_3613(paaG)
AVN: Avin_14230(ech)
AVL: AvCA_14230(ech)
AVD: AvCA6_14230(ech)
ACX: Achr_28510(ech)
ACB: A1S_1111
ABY: ABAYE2628(hcaA)
ABN: AB57_1195
ABAZ: P795_11770
ABAU: IX87_05290
ABAA: IX88_07805
ACC: BDGL_000391(hcaA)
ACI: ACIAD1726(hcaA)
CSA: Csal_0278
HAM: HALO0103
SALN: SALB1_1097
RSO: RSp0225(fca)
RSN: RSPO_m00213(fca)
RSE: F504_3664
BMA: BMAA0629
BMAL: DM55_4800
BMAE: DM78_3189
BMAQ: DM76_3754
BMAI: DM57_12400
BMAF: DM51_4342
BMAZ: BM44_4790
BMAB: BM45_4942
BPS: BPSS0779
BPM: BURPS1710b_A2361(ech)
BPSE: BDL_4061
BPSM: BBQ_5363
BPSU: BBN_4233
BPSD: BBX_5899
BPSH: DR55_4562
BPSA: BBU_5259
BVE: AK36_4870
BCN: Bcen_5223
BCJ: BCAM2793
BCEN: DM39_5052
BCEW: DM40_3360
BCEO: I35_6672
BAM: Bamb_4916
BMU: Bmul_3210
BMK: DM80_4590
BMUL: NP80_3343
BCT: GEM_5614
BCED: DM42_5195
BDL: AK34_5013
BCON: NL30_17810
BUB: BW23_3981
BLAT: WK25_29380
BTEI: WS51_10605
BSEM: WJ12_33825
BPSL: WS57_00300
BMEC: WJ16_32335
BSTG: WT74_32690
BGO: BM43_7003
BUK: MYA_3497
BUL: BW21_6349
PPNO: DA70_11115
PPNM: LV28_19940
PPUL: RO07_14150
PSPU: NA29_22960
PAPI: SG18_13975
AFQ: AFA_15960
DAC: Daci_2758
MLO: mlr1841
AVI: Avi_1705(fadB)
RLE: pRL120505(ech)
RLG: Rleg_4811
MET: M446_3478
META: Y590_19210
CCR: CC_2401
CAK: Caul_1132
CSE: Cseg_2345
NAR: Saro_1669
SPHI: TS85_18585
SSAN: NX02_02990
SJP: SJA_C1-02370(menB)
SSY: SLG_07870(ferB2) SLG_25030(ferB)
SPHR: BSY17_3548
BLAS: BSY18_3470
AAY: WYH_03221
ALB: AEB_P1354
AZL: AZL_b03680(paaG)
SEN: SACE_2794
PSEE: FRP1_10310
AMI: Amir_4116
KAL: KALB_2035
SUS: Acid_0255
 » show all
Taxonomy
Reference
1  [PMID:9611814]
  Authors
Narbad A, Gasson MJ.
  Title
Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens.
  Journal
Microbiology 144 ( Pt 5):1397-405 (1998)
DOI:10.1099/00221287-144-5-1397
Reference
2  [PMID:6870241]
  Authors
Pometto AL 3rd, Crawford DL.
  Title
Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus.
  Journal
Appl Environ Microbiol 45:1582-5 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.41
IUBMB Enzyme Nomenclature: 4.1.2.41
ExPASy - ENZYME nomenclature database: 4.1.2.41
BRENDA, the Enzyme Database: 4.1.2.41
CAS: 449168-60-9

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