KEGG   ENZYME: 4.1.2.44Help
Entry
EC 4.1.2.44                 Enzyme                                 

Name
2,3-epoxybenzoyl-CoA dihydrolase;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating);
BoxC;
dihydrodiol transforming enzyme;
benzoyl-CoA oxidation component C;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming);
benzoyl-CoA-dihydrodiol lyase (incorrect);
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA-semialdehyde-lyase (formate-forming)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)
Reaction(IUBMB)
2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate [RN:R09556]
Reaction(KEGG)
Substrate
2,3-epoxy-2,3-dihydrobenzoyl-CoA [CPD:C19684];
H2O [CPD:C00001]
Product
(3Z)-6-oxohex-3-enoyl-CoA [CPD:C19683];
formate [CPD:C00058]
Comment
The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate.
History
EC 4.1.2.44 created 2010, modified 2015
Pathway
ec00362  Benzoate degradation
Orthology
K15513  benzoyl-CoA-dihydrodiol lyase
Genes
ADI: B5T_02167
AXE: P40_10395
VFF: VITFI_CDS1591 VITFI_CDS1592
RPJ: N234_07050 N234_31285
REU: Reut_A1325
REH: H16_A1410(h16_A1410)
CNC: CNE_1c14380(boxC) CNE_2c18750(boxC)
CUH: BJN34_07190 BJN34_32100
RME: Rmet_1222
CTI: RALTA_A1323
CGD: CR3_3378(boxC)
BXE: Bxe_A1422(boxC) Bxe_C0892(boxC)
BXB: DR64_3586(boxC) DR64_7558(boxC)
BPH: Bphy_1540
BFN: OI25_2715(boxC)
PPNO: DA70_23855
PPNM: LV28_06855
PPUL: RO07_00940
PSPU: NA29_10725
PAPI: SG18_01115
BPT: Bpet3570
BHO: D560_2020(boxC)
BHM: D558_2005(boxC)
BHZ: ACR54_04085(boxC)
AXY: AXYL_05032(boxC)
AMIM: MIM_c27180(boxC)
RFR: Rfer_0220
POL: Bpro_1628
PNA: Pnap_2944
VEI: Veis_0732
DAC: Daci_0074
VPD: VAPA_1c00950(boxC)
CTES: O987_00315
RTA: Rta_22310
LIM: L103DPR2_00829(boxC)
LIH: L63ED372_02247(boxC)
HYR: BSY239_634(boxC)
HYB: Q5W_16390
CBAA: SRAA_0584
LCH: Lcho_3659
THI: THI_0468
SHD: SUTH_01643(boxC)
EBA: ebA2763(boxC)
AZO: azo3056
AZA: AZKH_4518(boXC)
AOA: dqs_3190
SCL: sce1061(boxC)
HOH: Hoch_5224
BJA: blr1080
BRA: BRADO6789
BBT: BBta_0749
BRS: S23_67360
AOL: S58_06710
RPA: RPA0676
RPB: RPB_4654
RPD: RPD_0880
RPE: RPE_0585
RPT: Rpal_0743
VGO: GJW-30_1_01039(boxC)
RBM: TEF_07965
SIL: SPO3700
JAN: Jann_0671(boxC)
PTP: RCA23_c19080(boxC)
SPSE: SULPSESMR1_02746(boxC)
AHT: ANTHELSMS3_04344(boxC)
MAG: amb0174
MAGX: XM1_1069(boxC)
MAGN: WV31_13520
BSD: BLASA_2557(boxC)
AMD: AMED_8611(paaG)
AMN: RAM_44195
AMM: AMES_8480(paaG)
AMZ: B737_8481(paaG)
AOI: AORI_7397(paaG)
AMQ: AMETH_6480(paaG)
PDX: Psed_1490
PSEE: FRP1_20440
PSEH: XF36_05455
CAI: Caci_2008
 » show all
Taxonomy
Reference
1  [PMID:15916608]
  Authors
Gescher J, Eisenreich W, Worth J, Bacher A, Fuchs G
  Title
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme.
  Journal
Mol Microbiol 56:1586-600 (2005)
DOI:10.1111/j.1365-2958.2005.04637.x
  Sequence
Reference
2  [PMID:20452977]
  Authors
Rather LJ, Knapp B, Haehnel W, Fuchs G
  Title
Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation.
  Journal
J Biol Chem 285:20615-24 (2010)
DOI:10.1074/jbc.M110.124156
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.44
IUBMB Enzyme Nomenclature: 4.1.2.44
ExPASy - ENZYME nomenclature database: 4.1.2.44
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.2.44
BRENDA, the Enzyme Database: 4.1.2.44

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