KEGG   ENZYME: 4.1.2.5Help
Entry
EC 4.1.2.5                  Enzyme                                 

Name
L-threonine aldolase;
L-threonine acetaldehyde-lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
L-threonine acetaldehyde-lyase (glycine-forming)
Reaction(IUBMB)
L-threonine = glycine + acetaldehyde [RN:R00751]
Reaction(KEGG)
Substrate
L-threonine [CPD:C00188]
Product
glycine [CPD:C00037];
acetaldehyde [CPD:C00084]
Comment
A pyridoxal-phosphate protein. This enzyme is specific for L-threonine and can not utilize L-allo-threonine. Different from EC 4.1.2.49, L-allo-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase.
History
EC 4.1.2.5 created 1961, deleted 1972, reinstated 1976, modified 2011
Pathway
ec00260  Glycine, serine and threonine metabolism
Reference
1  [PMID:5419751]
  Authors
Dainty RH
  Title
Purification and properties of threonine aldolase from Clostridium pasteurianum.
  Journal
Biochem J 117:585-92 (1970)
Reference
2  [PMID:13449064]
  Authors
KARASEK MA, GREENBERG DM.
  Title
Studies on the properties of threonine aldolases.
  Journal
J Biol Chem 227:191-205 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.5
IUBMB Enzyme Nomenclature: 4.1.2.5
ExPASy - ENZYME nomenclature database: 4.1.2.5
BRENDA, the Enzyme Database: 4.1.2.5
CAS: 62213-23-4

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