KEGG   ENZYME: 4.1.3.17Help
Entry
EC 4.1.3.17                 Enzyme                                 

Name
4-hydroxy-4-methyl-2-oxoglutarate aldolase;
pyruvate aldolase;
gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase;
4-hydroxy-4-methyl-2-ketoglutarate aldolase;
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase;
HMG aldolase;
CHA aldolase;
4-carboxy-4-hydroxy-2-oxoadipate aldolase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)
Reaction(IUBMB)
(1) 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate [RN:R00008];
(2) 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = oxaloacetate + pyruvate [RN:R00350]
Reaction(KEGG)
Substrate
4-hydroxy-4-methyl-2-oxoglutarate [CPD:C06033];
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate [CPD:C04115]
Product
pyruvate [CPD:C00022];
oxaloacetate [CPD:C00036]
Comment
Requires a divalent metal ion [3]. This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), phthalate, syringate and 3,4,5-trihydroxybenzoate [1-3]. The enzyme from Pseudomonas straminea can also catalyse the activity of EC 4.1.3.16, 4-hydroxy-2-oxoglutarate aldolase, and the decarboxylation of oxaloacetate [3].
History
EC 4.1.3.17 created 1972, modified 2012
Pathway
ec00362  Benzoate degradation
ec00660  C5-Branched dibasic acid metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K10218  4-hydroxy-4-methyl-2-oxoglutarate aldolase
Genes
KPN: KPN_04048
KPU: KP1_5417
KPM: KPHS_52180
KPP: A79E_0059
KPK: A593_10475
KPH: KPNIH24_25960
KPZ: KPNIH27_24945
KPV: KPNIH29_25905
KPW: KPNIH30_26300
KPY: KPNIH31_25375
KPT: VK055_3417(ligK)
KPE: KPK_0045(ligK)
KPR: KPR_0059
KPJ: N559_0095
KPX: PMK1_01554(galC)
KPNU: LI86_00295
KPNK: BN49_0059
KVA: Kvar_0051
KQV: B8P98_00290(ligK)
CRO: ROD_31651
RAO: DSD31_00330(ligK)
YPE: YPO0082
YPK: y0055
YPH: YPC_0244
YPA: YPA_3459
YPN: YPN_3766
YPG: YpAngola_A0092(ligK)
YPZ: YPZ3_0075
YPD: YPD4_0076
YPX: YPD8_0078
YPW: CH59_2176(ligK)
YPJ: CH55_3043(ligK)
YPV: BZ15_3486(ligK)
YPL: CH46_832(ligK)
YPS: YPTB0078
YPO: BZ17_2517(ligK)
YPI: YpsIP31758_0093(ligK)
YPY: YPK_4121
YPB: YPTS_0082
YPQ: DJ40_2345(ligK)
YPU: BZ21_3421(ligK)
YPR: BZ20_2043(ligK)
YPC: BZ23_3694(ligK)
YPF: BZ19_3540(ligK)
YMA: DA391_08510(ligK)
SPE: Spro_2091
SMAF: D781_1918
SERA: Ser39006_020445(ligK)
SERM: CLM71_09510(ligK)
RAA: Q7S_13290
EAM: EAMY_1950(fldZ)
EAY: EAM_1907
EBI: EbC_05350
LRI: NCTC12151_01639(proA_3)
XCC: XCC4030(fldZ)
XCB: XC_4119
XCP: XCR_0230(ligK)
XCV: XCV4253
XAX: XACM_4025
XAC: XAC4155(fldZ)
XCI: XCAW_00143(menG)
XOO: XOO4565(MenG)
XOM: XOO4301(XOO4301)
XOP: PXO_03235(ligK)
XOR: XOC_0386(ligK)
XPH: XppCFBP6546_13630(XppCFBP6546P_13630)
VFL: AL536_10295(ligK)
PCQ: PcP3B5_13890(galC)
PPU: PP_2514(gllC)
PPI: YSA_00539
PPX: T1E_3400
PPUT: L483_20175
PSES: PSCI_1781
PAT: Patl_3890
MBS: MRBBS_1267(proA)
CSA: Csal_0329
SALN: SALB1_0065
PSE: NH8B_2723
RSO: RSp1231
RSE: F504_4727
CNC: CNE_BB1p09170(proA) CNE_BB1p09540(menG1)
RME: Rmet_4205
CGD: CR3_3969(ligK)
BCEN: DM39_6582(ligK)
BCEO: I35_7832
BMU: Bmul_6038
BMK: DM80_6489(ligK)
BMUL: NP80_5250(ligK)
BCED: DM42_7333(ligK)
BUB: BW23_4782(ligK)
BTEI: WS51_29475
BPSL: WS57_17835
BMEC: WJ16_18640
BGP: BGL_2c20980(ligK)
BGO: BM43_6955(ligK)
BFN: OI25_7307
PHS: C2L64_29355(ligK)
PGP: CUJ91_20615(ligK)
PPNO: DA70_15095
PPNM: LV28_15585
PAPI: SG18_10130
HYF: DTO96_100890(proA_1)
BPT: Bpet3605
BHO: D560_0869(ligK)
BHM: D558_0855(ligK)
BHZ: ACR54_03615(proA_5)
BTRM: SAMEA390648700633(proA_1)
ASW: CVS48_21725(ligK)
AFQ: AFA_05530(ligK)
RFR: Rfer_0337
POL: Bpro_4321
ACRA: BSY15_1207(ligK)
DAC: Daci_4448
VAM: C4F17_02075(ligK)
CTES: O987_16280
RTA: Rta_24790
OTK: C6570_16470(ligK)
LIM: L103DPR2_01493(proA_3)
LIH: L63ED372_01141(proA_1)
HYR: BSY239_2225(ligK)
HYB: Q5W_10755
CBAA: SRAA_1353
CBAB: SMCB_0792
HSE: Hsero_4461(menG)
HEE: hmeg3_19345(ligK)
LCH: Lcho_3633
AZO: azo2541
AOA: dqs_2698
TCL: Tchl_1059
SME: SMc00502
SMX: SM11_chr1634(fldZ)
SMER: DU99_09655
ATU: Atu4285(menG)
ARA: Arad_2915(ligK) Arad_7492(menG)
ATF: Ach5_37280(menG)
AVI: Avi_7652(menG)
RET: RHE_PC00179(menG)
RLG: Rleg_6375
RHT: NT26_3186(ligK)
SHZ: shn_02600
BJA: blr3642(menG) blr3842
BRA: BRADO2338(ligK)
BBT: BBta_2698(ligK)
BRS: S23_44010
AOL: S58_52610
BRAD: BF49_1199
BRO: BRAD285_4999(ligK)
BOT: CIT37_34675(ligK)
RPA: RPA4698(FldZ)
RPB: RPB_0876
RPD: RPD_0986
RPE: RPE_0747
RPT: Rpal_5179
AZC: AZC_3351
MOR: MOC_5209(ligK)
MAQU: Maq22A_c23285(menG)
PHL: KKY_3764
MMED: Mame_01728
BRN: D1F64_00905(ligK)
RSP: RSP_3170
PARO: CUV01_03960(ligK)
KVU: EIO_1889
KVL: KVU_1347(menG) KVU_1364
MALG: MALG_02283
RBG: BG454_07495(ligK)
SAGU: CDO87_02620(ligK)
NAR: Saro_2817
NOV: TQ38_025045(ligK) TQ38_028390(ligK)
SMAZ: LH19_17715
SWI: Swit_3070
SPHD: HY78_10225
SSAN: NX02_17525
SPHC: CVN68_17265(ligK)
SSY: SLG_12550(ligK) SLG_19060
SPHB: EP837_03487(ligK)
SPHR: BSY17_3451(ligK)
SINB: SIDU_17270
SHYD: CJD35_16800(ligK) CJD35_19550(ligK)
SYA: A6768_17500(ligK)
SFLA: SPHFLASMR4Y_02983(proA)
SPHY: CHN51_00920(ligK)
BLAS: BSY18_3519(ligK)
AAY: WYH_01904(proA_1)
ADO: A6F68_01084(proA_3)
ROS: CTJ15_00845(ligK)
MAG: amb0252
MAGX: XM1_1088(ligK)
MAGN: WV31_13600
THAC: CSC3H3_15790(ligK)
MAGQ: MGMAQ_2665(ligK)
NCB: C0V82_22475(ligK)
BEO: BEH_09090
AAC: Aaci_1611
AAD: TC41_1506(hps-phi)
ECAS: ECBG_00911
RER: RER_03060
ROP: ROP_28310
GOR: KTR9_0698
SFA: Sfla_0532
SBH: SBI_05192
SALB: XNR_3394
STRP: F750_6350
SLE: sle_08630(sle_08630)
STRD: NI25_00235
SLAU: SLA_7096
KSK: KSE_75160(pcmE)
MHOS: CXR34_05660(ligK)
AMIN: AUMI_19430
AUW: AURUGA1_00415(galC)
ART: Arth_4375
ARX: ARZXY2_4178(ligK)
AAU: AAur_3908
MPH: MLP_19810
SRO: Sros_9409
BSD: BLASA_2604(ligK)
MMAR: MODMU_2829(ligK)
PDX: Psed_3699
PSEA: WY02_25105
PSEE: FRP1_23140
ACTN: L083_3805
PLAB: C6361_05905(ligK)
PLAT: C6W10_02450(ligK)
RXY: Rxyl_0200
CWO: Cwoe_5004
TRO: trd_0905
STI: Sthe_2848
MRB: Mrub_2677
SUS: Acid_6636
SLI: Slin_4023
MSE: Msed_1057
 » show all
Taxonomy
Reference
1  [PMID:5076765]
  Authors
Tack BF, Chapman PJ, Dagley S.
  Title
Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase.
  Journal
J Biol Chem 247:6444-9 (1972)
Reference
2
  Authors
Wood, W.A.
  Title
2-Keto-3-deoxy-6-phosphogluconic and related aldolases.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.
Reference
3  [PMID:2229032]
  Authors
Maruyama K
  Title
Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase from Pseudomonas ochraceae grown on phthalate.
  Journal
J Biochem 108:327-33 (1990)
Reference
4  [PMID:21219457]
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
  Sequence
[ppu:PP_2514]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.17
IUBMB Enzyme Nomenclature: 4.1.3.17
ExPASy - ENZYME nomenclature database: 4.1.3.17
BRENDA, the Enzyme Database: 4.1.3.17
CAS: 37290-65-6

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