KEGG   ENZYME: 4.2.1.100Help
Entry
EC 4.2.1.100                Enzyme                                 

Name
cyclohexa-1,5-dienecarbonyl-CoA hydratase;
cyclohexa-1,5-diene-1-carbonyl-CoA hydratase;
dienoyl-CoA hydratase;
cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect);
6-hydroxycyclohex-1-enecarbonyl-CoA hydro-lyase (cyclohexa-1,5-dienecarbonyl-CoA-forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
6-hydroxycyclohex-1-ene-1-carbonyl-CoA hydro-lyase (cyclohexa-1,5-diene-1-carbonyl-CoA-forming)
Reaction(IUBMB)
6-hydroxycyclohex-1-ene-1-carbonyl-CoA = cyclohexa-1,5-diene-1-carbonyl-CoA + H2O [RN:R05597]
Reaction(KEGG)
Substrate
6-hydroxycyclohex-1-ene-1-carbonyl-CoA [CPD:C06749]
Product
cyclohexa-1,5-diene-1-carbonyl-CoA [CPD:C06322];
H2O [CPD:C00001]
Comment
Forms part of the anaerobic benzoate degradation pathway, which also includes EC 1.3.8.6 [glutaryl-CoA dehydrogenase (ETF)], EC 1.3.7.8 (benzoyl-CoA reductase) and EC 4.2.1.55 (3-hydroyxbutyryl-CoA dehydratase).
History
EC 4.2.1.100 created 2000, modified 2001
Pathway
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07537  cyclohexa-1,5-dienecarbonyl-CoA hydratase
Genes
SHD: SUTH_01654(dch)
EBA: ebA5296(dch)
AZI: AzCIB_4483
TMZ: Tmz1t_2952
GME: Gmet_2150(bamR)
GBM: Gbem_1432(bamR)
GEO: Geob_0098(bamR)
GEM: GM21_2822
GPI: GPICK_09515
DTO: TOL2_C38220
SAT: SYN_01653
RVA: Rvan_0036
MAG: amb2142
 » show all
Taxonomy
Reference
1  [PMID:9738901]
  Authors
Laempe D, Eisenreich W, Bacher A, Fuchs G.
  Title
Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica.
  Journal
Eur J Biochem 255:618-27 (1998)
DOI:10.1046/j.1432-1327.1998.2550618.x
  Sequence
Reference
2  [PMID:8990279]
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
3  [PMID:8436125]
  Authors
Koch J, Eisenreich W, Bacher A, Fuchs G.
  Title
Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism.
  Journal
Eur J Biochem 211:649-61 (1993)
DOI:10.1111/j.1432-1033.1993.tb17593.x
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.100
IUBMB Enzyme Nomenclature: 4.2.1.100
ExPASy - ENZYME nomenclature database: 4.2.1.100
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.100
BRENDA, the Enzyme Database: 4.2.1.100
CAS: 214355-79-0

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