KEGG   ENZYME: 4.2.1.106Help
Entry
EC 4.2.1.106                Enzyme                                 

Name
bile-acid 7alpha-dehydratase;
baiE (gene name);
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase;
7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming);
BA7 alpha dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
7alpha,12alpha-dihydroxy-3-oxochol-4-enoyl-CoA hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoyl-CoA-forming)
Reaction(IUBMB)
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O [RN:R11565]
Reaction(KEGG)
R11565;
(other) R07318 R11566
Show
Substrate
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA [CPD:C21469]
Product
12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA [CPD:C21470];
H2O [CPD:C00001]
Comment
This enzyme, characterized from the gut bacterium Clostridium scindens (previously known as Eubacterium sp. strain VPI 12708), participates in the 7-dehydroxylation process associated with bile acid degradation.
History
EC 4.2.1.106 created 2005, modified 2016
Pathway
ec00121  Secondary bile acid biosynthesis
Orthology
K15872  bile-acid 7alpha-dehydratase
Reference
1  [PMID:2254270]
  Authors
Mallonee DH, White WB, Hylemon PB
  Title
Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708.
  Journal
J Bacteriol 172:7011-9 (1990)
DOI:10.1128/JB.172.12.7011-7019.1990
Reference
2  [PMID:8808760]
  Authors
Dawson JA, Mallonee DH, Bjorkhem I, Hylemon PB.
  Title
Expression and characterization of a C24 bile acid 7 alpha-dehydratase from Eubacterium sp. strain VPI 12708 in Escherichia coli.
  Journal
J Lipid Res 37:1258-67 (1996)
  Sequence
Reference
3  [PMID:26650892]
  Authors
Bhowmik S, Chiu HP, Jones DH, Chiu HJ, Miller MD, Xu Q, Farr CL, Ridlon JM, Wells JE, Elsliger MA, Wilson IA, Hylemon PB, Lesley SA
  Title
Structure and functional characterization of a bile acid 7alpha dehydratase BaiE  in secondary bile acid synthesis.
  Journal
Proteins 84:316-31 (2016)
DOI:10.1002/prot.24971
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.106
IUBMB Enzyme Nomenclature: 4.2.1.106
ExPASy - ENZYME nomenclature database: 4.2.1.106
BRENDA, the Enzyme Database: 4.2.1.106

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