KEGG   ENZYME: 4.2.1.117Help
Entry
EC 4.2.1.117                Enzyme                                 

Name
2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate forming)
Reaction(IUBMB)
(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O [RN:R11263]
Reaction(KEGG)
Substrate
(2S,3S)-2-methylcitrate [CPD:C02225]
Product
2-methyl-trans-aconitate [CPD:C21250];
H2O [CPD:C00001]
Comment
Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein.
History
EC 4.2.1.117 created 2009
Pathway
ec00640  Propanoate metabolism
Orthology
K20455  2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
Genes
MVR: X781_5050
GAN: UMN179_00522
XFM: Xfasm12_0580
XFN: XfasM23_0533 XfasM23_0534
XFF: XFLM_08000 XFLM_08005
XFL: P303_02085
XFH: XFHB_09405
XTW: AB672_03330
XCC: XCC1033(acnA)
XCB: XC_3213
XCA: xcc-b100_3312(acnD)
XCP: XCR_1232(acnD)
XCV: XCV1158(acnA)
XAX: XACM_1105(acnA)
XAC: XAC1139(acnA)
XCI: XCAW_01239(acnA)
XFU: XFF4834R_chr11330(acnA)
XAO: XAC29_05720(acnA)
XOO: XOO0894(acnA)
XOM: XOO0819(XOO0819)
XOP: PXO_02721(acnD)
XOR: XOC_1188(acnD)
XAL: XALC_0641
XPH: XppCFBP6546_05890(XppCFBP6546P_05890)
XVA: C7V42_06010(acnD)
SML: Smlt3608(acnA)
SMT: Smal_3028
SMZ: SMD_3180(acnA)
SACZ: AOT14_26190(acnA)
STEN: CCR98_15750(acnD)
STEM: CLM74_16065(acnD)
PSUW: WQ53_05990
PSD: DSC_08815(acnA)
LYT: DWG18_11265(acnD)
LUM: CNR27_06390(acnD)
XBA: C7S18_05510(acnD)
VCH: VC1338
VCS: MS6_1116
VCE: Vch1786_I0840(acnA)
VCI: O3Y_06225
VCO: VC0395_A0954(acnA)
VCR: VC395_1457(acnA)
VCM: VCM66_1293(acnA)
VCX: VAA049_1460(acnD)
VCZ: VAB027_2016(acnD)
VVU: VV1_2730(acnD)
VVY: VV1531
VPA: VP1646
VPB: VPBB_1506
VAG: N646_0711
VSP: VS_1345
VAN: VAA_02060
VAU: VANGNB10_cI1220(acnA)
VSC: VSVS12_03132(acnA)
VQI: CCZ37_06100(acnD)
VTA: A0778
PAE: PA0794
PAEV: N297_821(acnD)
PAEI: N296_821(acnD)
PAP: PSPA7_4724(acnD)
PAEP: PA1S_22680
PAEM: U769_22185
PAEL: T223_23200
PAEG: AI22_11480
PAEC: M802_818(acnD)
PAEO: M801_821(acnD)
PMY: Pmen_2082
PMK: MDS_2638
PPSE: BN5_2137(acnC)
PCQ: PcP3B5_51740(acoA)
PPU: PP_2336(acnA-II)
PPF: Pput_3434
PPI: YSA_01156
PPX: T1E_5346
PPUH: B479_09495
PPUT: L483_09440
PPUN: PP4_34830
PMON: X969_07550
PMOT: X970_07525
PSB: Psyr_2087
PSP: PSPPH_2058(acnD)
PAMG: BKM19_013080(acnD)
PAVL: BKM03_17835(acnD)
PFL: PFL_1863(acnD)
PPRC: PFLCHA0_c18940(acnA1)
PPRO: PPC_1907
PFS: PFLU_4630
PFC: PflA506_3933(acnD)
PFW: PF1751_v1c41380(acnA)
PFB: VO64_4909
PMAN: OU5_5388
PEN: PSEEN1905
PSA: PST_2036
PSZ: PSTAB_1936(acnD)
PSTT: CH92_09085
PPUU: PputUW4_03656(acnA2)
PKC: PKB_4871(acna3)
PSES: PSCI_4833
PSEM: TO66_09555
PSEC: CCOS191_1801(acnA1)
PSOS: POS17_1870
PANR: A7J50_4330
PSET: THL1_3678
PSIL: PMA3_20475
AVN: Avin_23230(acnD)
AVL: AvCA_23230(acnD)
AVD: AvCA6_23230(acnD)
ACX: Achr_23310(acnD)
PAR: Psyc_1112
PALI: A3K91_1325
PSYC: DABAL43B_1466(acnA1)
PSYA: AOT82_405
ACB: A1S_0076
ABM: ABSDF0093
ABY: ABAYE3791
ABN: AB57_0124
ABB: ABBFA_003437(acnD)
ABX: ABK1_0114
ABZ: ABZJ_00107(acnD)
ABD: ABTW07_0109(acnD)
ABH: M3Q_312
ABAD: ABD1_00780(acnA)
ABAZ: P795_16830
ABAU: IX87_14990
ABAA: IX88_02700
ACC: BDGL_003000(acnA)
ACI: ACIAD2755
ASJ: AsACE_CH02227(acnA)
AID: CTZ23_03590(acnD)
ADV: DJ533_15150(acnD)
ARJ: DOM24_11490(acnD)
MBAH: HYN46_12340(acnD)
SON: SO_0343(acnD)
SDN: Sden_1666
SFR: Sfri_1859
SAZ: Sama_3296
SBL: Sbal_4049
SLO: Shew_1822
SSE: Ssed_2113
SPL: Spea_2320
SHL: Shal_1963
SWD: Swoo_2497
SWP: swp_2430
SVO: SVI_3079(acnA)
SHF: CEQ32_14310(acnD)
SPSW: Sps_02027
SHEW: CKQ84_05840(acnD)
ILO: IL1425
CPS: CPS_2820
PHA: PSHAa1773(acnA)
PAT: Patl_1421
PSM: PSM_A1293(acnA)
PSEO: OM33_11280
PTN: PTRA_a2204(acnA)
PPIS: B1L02_22040(acnD)
PEA: PESP_a1600(acnA)
PSPO: PSPO_a1774(acnA)
PART: PARC_a2381(acnA)
PTU: PTUN_a2276(acnA)
PNG: PNIG_a2385(acnA)
PTD: PTET_a1485(acnA)
PSEN: PNC201_21065(acnA)
MAQ: Maqu_1664
MHC: MARHY1632(acnA)
MAD: HP15_1930(acnA)
MBS: MRBBS_2223(acnA)
MARA: D0851_03260(acnD)
AMAL: I607_14930
AMAE: I876_15230
AMAO: I634_15175
AMAD: I636_15035
AMAI: I635_15610
AMAG: I533_14750
AMAC: MASE_14785
ASP: AOR13_333
GNI: GNIT_3156
GPS: C427_2936
SALH: HMF8227_00163(acnA)
SALM: D0Y50_15030(acnD)
PIN: Ping_1867
FBL: Fbal_3659
MVS: MVIS_1682
MICC: AUP74_02432(citB)
MII: BTJ40_12485(acnD)
CYQ: Q91_0261
AEH: Mlg_2603
HAM: HALO1855
HCO: LOKO_02859(acnA_1)
HHH: CLM76_12695(acnD)
HBE: BEI_0898(acnD)
HAF: C8233_08260(acnD)
ABO: ABO_1431(acna)
ADI: B5T_02360(acnA)
APAC: S7S_09560
AXE: P40_11335
KKO: Kkor_1000
KGE: TQ33_0831
TOL: TOL_1637
BSAN: CHH28_14935(acnD)
AMED: B224_2929
AEA: C2U39_13120(acnD)
ARV: C7N77_12230(acnD)
OCE: GU3_09930
SOK: D0B54_06890(acnD)
NME: NMB0433(acnA)
NMP: NMBB_0476
NMH: NMBH4476_0426(acnD)
NMD: NMBG2136_1667(acnD)
NMM: NMBM01240149_1655(acnD)
NMS: NMBM01240355_0442(acnD)
NMQ: NMBM04240196_0440(acnD)
NMZ: NMBNZ0533_1816(acnD)
NMA: NMA2052
NMW: NMAA_1503(acnA)
NMX: NMA510612_2314(acnA)
NMC: NMC1729(acnA)
NMN: NMCC_1713(acnA)
NMT: NMV_0476(acnA)
NMI: NMO_1607(acnA)
NWE: SAMEA3174300_1284(acnA)
NSI: A6J88_05110(acnD)
NMJ: NM96_13345(acnD)
CVI: CV_2054(acnA2)
CHRO: CXB49_12305(acnD)
CHRI: DK842_17400(acnD)
LHK: LHK_02309
PSE: NH8B_1568(acnA)
RSO: RSp0120(acnA2)
RSL: RPSI07_mp0085(acnA)
RSN: RSPO_m00103(acnA2)
RSM: CMR15_mp10089(acnA1)
RSE: F504_3571
RPI: Rpic_3859
RIN: ACS15_5552(acnD)
REH: H16_A1907(acnM)
CNC: CNE_1c18860(acnA)
RME: Rmet_1585(acnA1)
CTI: RALTA_A1601(acnA1)
CGD: CR3_1236(acnA)
BMA: BMAA1868(acnM)
BMV: BMASAVP1_0877(acnM)
BML: BMA10229_1163(acnM)
BMN: BMA10247_A2141(acnM)
BMAL: DM55_3915(acnD)
BMAE: DM78_4834(acnD)
BMAQ: DM76_4612(acnD)
BMAI: DM57_06685
BMAF: DM51_3561(acnD)
BMAZ: BM44_3873(acnD)
BMAB: BM45_4649(acnD)
BPS: BPSS0208(acnA)
BPM: BURPS1710b_A1738(acnD)
BPL: BURPS1106A_A0290(acnD)
BPD: BURPS668_A0384(acnD)
BPSE: BDL_6100(acnD)
BPSM: BBQ_6004(acnD)
BPSU: BBN_3590(acnD)
BPSD: BBX_5270(acnD)
BPZ: BP1026B_II0231(acnA)
BPK: BBK_5402(acnD)
BPSH: DR55_5153(acnD)
BPSA: BBU_5923(acnD)
BPSO: X996_4921(acnD)
BUT: X994_4470(acnD)
BTE: BTH_II2187(acnD)
BTQ: BTQ_5473(acnD)
BTJ: BTJ_4129(acnD)
BTZ: BTL_4940(acnD)
BTD: BTI_4521(acnD)
BTV: BTHA_5283(acnD)
BTHE: BTN_4597(acnD)
BTHM: BTRA_4864(acnD)
BTHA: DR62_4706
BTHL: BG87_4930(acnD)
BOK: DM82_4212(acnD)
BOC: BG90_3811(acnD)
BVE: AK36_3086(acnD)
BCN: Bcen_5346
BCJ: BCAM2701(acnA)
BCEN: DM39_5180(acnD)
BCEW: DM40_3288(acnD)
BCEO: I35_6587(acnA)
BAM: Bamb_4840
BMU: Bmul_3289
BMK: DM80_4669(acnD)
BMUL: NP80_3264(acnD)
BCT: GEM_5708
BCED: DM42_5284(acnD)
BDL: AK34_3200(acnD)
BCON: NL30_17380
BUB: BW23_3900(acnD)
BLAT: WK25_29015
BTEI: WS51_10205
BSEM: WJ12_33415
BPSL: WS57_00900
BMEC: WJ16_31865
BSTG: WT74_32245
BGU: KS03_3757(acnD)
BGO: BM43_6616(acnD)
BUK: MYA_3313
BUL: BW21_4044(acnD)
BXE: Bxe_B2301
BXB: DR64_4633(acnD)
BPH: Bphy_6708
BFN: OI25_4745(acnD)
PARB: CJU94_32085(acnD)
PHS: C2L64_36160(acnD)
PTER: C2L65_31370(acnD)
PGP: CUJ91_19280(acnD)
PPNO: DA70_01070
PPNM: LV28_05260
PPUL: RO07_24285
PSPU: NA29_12385
PAPI: SG18_23645
PLG: NCTC10937_02040(acnD_1)
HYF: DTO96_101978(acnD)
BPE: BP2369(acnA)
BPC: BPTD_2326(acnA)
BPER: BN118_2575(acnA)
BPET: B1917_2280(acnA)
BPEU: Q425_22610(acnA)
BPA: BPP3235(acnA)
BPAR: BN117_3199(acnA)
BBR: BB3687(acnA)
BBM: BN115_3358(acnA)
BBH: BN112_4729(acnA)
BBX: BBS798_3466(acnA)
BPT: Bpet1814(acnA1)
BAV: BAV2732(acnA4)
BHO: D560_0252(acnD)
BHM: D558_0247(acnD)
BHZ: ACR54_00997(acnA_2)
BTRM: SAMEA390648701960(acnA1)
AXY: AXYL_05733(acnD)
AXX: ERS451415_05484(acnA)
ASW: CVS48_10145(acnD)
ACHR: C2U31_00650(acnD)
PUT: PT7_0413
AMIM: MIM_c31340(acnD)
BPSI: IX83_00605
ODI: ODI_R1102
AJS: Ajs_1634
AAA: Acav_2474
VBO: CKY39_08425(acnD)
VAM: C4F17_06075(acnD)
CTES: O987_07245
OTK: C6570_10050(acnD)
MELM: C7H73_11740(acnD)
JAG: GJA_2037(acnD)
JSV: CNX70_18820(acnD)
HSE: Hsero_2283(acnA)
HRB: Hrubri_2539(acnA)
HEE: hmeg3_15430(acnD)
CARE: LT85_3287
CPRA: CPter91_4110(acnD)
MASS: CR152_31095(acnD)
MASZ: C9I28_09980(acnD)
MTIM: DIR46_05400(acnD)
MASY: DPH57_11990(acnD)
AON: DEH84_12310(acnD)
GCA: Galf_0095
THK: CCZ27_07420(acnD)
ABU: Abu_0278(acnA)
ABT: ABED_0261
ABL: A7H1H_0281(acnD)
ARC: ABLL_0421
NOV: TQ38_026850(acnD)
SMAZ: LH19_12445
SWI: Swit_4787
SPHD: HY78_00750
SHYD: CJD35_17060(acnD)
NCB: C0V82_17970(acnD)
 » show all
Taxonomy
Reference
1  [PMID:14702315]
  Authors
Grimek TL, Escalante-Semerena JC
  Title
The acnD genes of Shewenella oneidensis and Vibrio cholerae encode a new Fe/S-dependent 2-methylcitrate dehydratase enzyme that requires prpF function in  vivo.
  Journal
J Bacteriol 186:454-62 (2004)
DOI:10.1128/JB.186.2.454-462.2004
  Sequence
[son:SO_0343]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.117
IUBMB Enzyme Nomenclature: 4.2.1.117
ExPASy - ENZYME nomenclature database: 4.2.1.117
BRENDA, the Enzyme Database: 4.2.1.117

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