KEGG   ENZYME: 4.2.1.129Help
Entry
EC 4.2.1.129                Enzyme                                 

Name
squalene---hopanol cyclase;
squalene---hopene cyclase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
hopan-22-ol hydro-lyase
Reaction(IUBMB)
hopan-22-ol = squalene + H2O [RN:R07323]
Reaction(KEGG)
Substrate
hopan-22-ol [CPD:C06309]
Product
squalene [CPD:C00751];
H2O [CPD:C00001]
Comment
The enzyme produces the cyclization products hopene (cf. EC 5.4.99.17) and hopanol from squalene at a constant ratio of 5:1.
History
EC 4.2.1.129 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K06045  squalene-hopene/tetraprenyl-beta-curcumene cyclase
Genes
MGR: MGG_00792
FOX: FOXG_17453
PLJ: VFPFJ_10743
PFY: PFICI_08232
PSCO: LY89DRAFT_588691
AFM: AFUA_5G00110 AFUA_7G00260
AFV: AFLA_125760
ACT: ACLA_024280
NFI: NFIA_112770
PCS: Pc22g24190
TTU: TERTU_3240(shc)
LFA: LFA_3651(shc)
MCA: MCA0812(sqhC)
MAH: MEALZ_2523(shc) MEALZ_3097(shc)
MPSY: CEK71_04645(shc) CEK71_11190(shc)
NOC: Noc_1320
NHL: Nhal_1309
NWA: Nwat_1202
NTT: TAO_1298
ACII: C4901_05415(shc)
SALN: SALB1_2148
REH: H16_B2207(sqhC)
CNC: CNE_2c21850(shc)
RME: Rmet_4148(sqhC) Rmet_4403(shc)
CTI: RALTA_B1983(shc)
CGD: CR3_3463(shc)
BMA: BMAA2100(shc)
BMV: BMASAVP1_1129(shc)
BML: BMA10229_1408(shc)
BMN: BMA10247_A2394(shc)
BMAL: DM55_3714(shc)
BMAE: DM78_4588(shc)
BMAQ: DM76_4409(shc)
BMAI: DM57_14635
BMAF: DM51_3764(shc)
BMAZ: BM44_3673(shc)
BMAB: BM45_4450(shc)
BPS: BPSS2339(shc)
BPM: BURPS1710b_A1490(shc)
BPL: BURPS1106A_A3161(shc)
BPD: BURPS668_A3275(shc)
BPSE: BDL_5818(shc)
BPSM: BBQ_3760(shc)
BPSU: BBN_5840(shc)
BPSD: BBX_4987(shc)
BPZ: BP1026B_II2520(shc)
BPK: BBK_5125(shc)
BPSH: DR55_5386(shc)
BPSA: BBU_3646(shc)
BPSO: X996_5156(shc)
BUT: X994_4705(shc)
BTE: BTH_II2359(shc)
BTQ: BTQ_3274(shc)
BTJ: BTJ_4306(shc)
BTZ: BTL_5108(shc)
BTD: BTI_4772(shc)
BTV: BTHA_5108(shc)
BTHE: BTN_4769(shc)
BTHM: BTRA_5036(shc)
BTHA: DR62_4873
BTHL: BG87_5103(shc)
BOK: DM82_3978(shc)
BOC: BG90_4049(shc)
BVE: AK36_4901(shc)
BCJ: BCAM2831(shc) BCAS0167(shc)
BCEN: DM39_5013(shc) DM39_6527(shc)
BCEW: DM40_3396(shc)
BCEO: I35_6711(shc) I35_7176(shc)
BMJ: BMULJ_05535(sqhC)
BMK: DM80_4553(shc) DM80_6441(shc)
BMUL: NP80_3379(shc)
BCT: GEM_5581
BCED: DM42_5157(shc) DM42_6654(shc)
BDL: AK34_4974(shc)
BUB: BW23_4001(shc) BW23_5528(shc)
BLAT: WK25_29560
BGU: KS03_3364(shc) KS03_3646(shc)
BGO: BM43_6721(shc) BM43_7081(shc)
BUK: MYA_3465
BUL: BW21_4301(shc)
BXE: Bxe_B0012
BXB: DR64_5376(shc)
BPH: Bphy_4137
BFN: OI25_5474(shc)
PARB: CJU94_28535(shc)
PHS: C2L64_18375(shc)
PTER: C2L65_16210(shc)
PGP: CUJ91_29990(shc)
PPNO: DA70_09090
PPNM: LV28_21715
PSPU: NA29_21045
PAPI: SG18_24805
BBAG: E1O_05330
NEU: NE1168
NET: Neut_1507
NLC: EBAPG3_003585(shc)
GSU: GSU0688(shc-1) GSU3061(shc-2)
GSK: KN400_0662(shc-1) KN400_3000(shc-2)
GME: Gmet_0419(shc-2) Gmet_2820(shc-1)
GUR: Gura_1020
GLO: Glov_2233
GBM: Gbem_1815 Gbem_3360(shc)
GEO: Geob_3234(shc-2) Geob_3662(shc-1)
GEB: GM18_3439
PCA: Pcar_0355(shc-1) Pcar_0441(shc-2)
DHY: DESAM_22870(shc)
DAL: Dalk_0344
RHI: NGR_a00460(shc)
BJA: blr3004(shc)
BRA: BRADO6252(shc)
BBT: BBta_1355(shc)
BRS: S23_49930(shc)
AOL: S58_64230
BRAD: BF49_1688
BRO: BRAD285_6198(shc)
BRK: CWS35_18225(shc)
BOT: CIT37_38575(shc)
RPA: RPA3740(sqhC)
RPB: RPB_1726
RPC: RPC_1720
RPD: RPD_3573
RPE: RPE_4468
RPT: Rpal_4261
NWI: Nwi_2269
NHA: Nham_2682
OCA: OCAR_6671(shc)
OCG: OCA5_c13970(shc)
OCO: OCA4_c13970(shc)
VGO: GJW-30_1_02142(shc)
MEX: Mext_1944
MEA: Mex_1p1818(shc)
MDI: METDI2705(shc)
MPO: Mpop_1835
MET: M446_6347
MNO: Mnod_7146
MOR: MOC_3575(shc) MOC_6001
META: Y590_09040
MAQU: Maq22A_c25255(sqhC)
MEE: DA075_06145(shc)
METD: C0214_10795(shc)
BID: Bind_3156
MSL: Msil_3243
HDN: Hden_0477
HMC: HYPMC_3771(shc)
RVA: Rvan_3017
MSC: BN69_1707
MTW: CQW49_17110(shc)
RBM: TEF_04810
SPHM: G432_09180
GOX: GOX2260
ACR: Acry_1685
AMV: ACMV_17290(shc)
GDI: GDI1620
GDJ: Gdia_1825
GXY: GLX_03980
GXL: H845_2357
APK: APA386B_146(shc) APA386B_1683(shc)
ASZ: ASN_2208(shc)
APOM: CPF11_00890(shc) CPF11_06325(shc)
ATO: CIW82_01590(shc)
ACET: DS739_01115(shc) DS739_06780(shc)
ROS: CTJ15_07690(shc)
RRU: Rru_A0062
RRF: F11_00315
MAG: amb1367
MAGX: XM1_1990(shc)
MAGN: WV31_17685
ABS: AZOBR_p150003(shc)
AZT: TSH58p_24395(shc)
MAGQ: MGMAQ_1494(shc)
NAO: Y958_22670(shc)
AFR: AFE_2124(shc)
ACU: Atc_2240
AAC: Aaci_2443
AAD: TC41_2733(shc)
SCO: SCO6764(SC6A5.13)
SMA: SAVERM_1650(hopA)
SGR: SGR_962(hopA)
SGB: WQO_30780
SCB: SCAB_12951(hopA)
SCT: SCAT_4943(shc) SCAT_5607
SFA: Sfla_0644
SBH: SBI_00220 SBI_02586(hopA)
SHY: SHJG_7654
SVE: SVEN_6451
SDV: BN159_1597(shc)
SALB: XNR_0267
SALS: SLNWT_6814
STRP: F750_6225
SFI: SFUL_6533
SLV: SLIV_04695(shc)
STRE: GZL_01982
SLD: T261_1203
STRM: M444_28180
SAMB: SAM23877_6414(shc)
SPRI: SPRI_0982
SLE: sle_10520(sle_10520)
SRN: A4G23_05042(shc)
STRD: NI25_04620
SLAU: SLA_6410
SALF: SMD44_07318(shc)
SALJ: SMD11_1098(shc)
SLX: SLAV_07390(shc)
SFK: KY5_7137
KSK: KSE_17590
FAL: FRAAL1432(shc1) FRAAL2491(shc2)
ACE: Acel_1697
BSD: BLASA_0211(shc)
SEN: SACE_4327(shc1)
AMQ: AMETH_4077(shc1)
AMYC: CU254_13920(shc)
PDX: Psed_3680
PSEH: XF36_18915
AMI: Amir_4385
KAL: KALB_4044
ACTI: UA75_12830
ACAD: UA74_12750
AHG: AHOG_12025(shc)
ALL: CRK61965
MIL: ML5_4686
PLAB: C6361_04775(shc)
PLAT: C6W10_01300(shc)
CAI: Caci_6664
AEY: CDG81_09445(shc)
RXY: Rxyl_2756
SYN: slr2089(shc)
SYZ: MYO_114140(shc)
SYY: SYNGTS_1402(shc)
SYT: SYNGTI_1402(shc)
SYS: SYNPCCN_1401(shc)
SYQ: SYNPCCP_1401(shc)
SYJ: D082_00070(shc)
SYO: C7I86_07260(shc)
TEL: tlr2309(shc)
THN: NK55_08140(sqhC)
HHG: XM38_041670(shc)
AMR: AM1_4845(shc)
MAR: MAE_44950(shc)
MPK: VL20_2504
CYT: cce_4510(shc)
TER: Tery_0727
GVI: gvip545(shc)
GLJ: GKIL_2413(shc)
ANA: all0775
NOE: CLI64_14195(shc)
AVA: Ava_4671
CEO: ETSB_1175(shc)
STI: Sthe_2007
AMU: Amuc_0525
MIN: Minf_0399(sqhC)
ACA: ACP_3329(shc)
ABAS: ACPOL_1272
GBA: J421_6268
MBAS: ALGA_3836
FLN: FLA_1944
NDE: NIDE0861(shc)
NMV: NITMOv2_0719(shc)
NIO: NITINOP_1569(shc)
NJA: NSJP_1836(shc)
LFC: LFE_1762
BANA: BARAN1_1143(shc)
MOX: DAMO_0045(shc)
MBAR: MSBR2_0931
IHO: Igni_0441
IIS: EYM_07905
BARC: AOA65_0750
 » show all
Taxonomy
Reference
1  [PMID:15136801]
  Authors
Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A
  Title
Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring.
  Journal
Org Biomol Chem 2:1456-70 (2004)
DOI:10.1039/b401172d
Reference
2  [PMID:15056909]
  Authors
Sato T, Kouda M, Hoshino T
  Title
Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius.
  Journal
Biosci Biotechnol Biochem 68:728-38 (2004)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.129
IUBMB Enzyme Nomenclature: 4.2.1.129
ExPASy - ENZYME nomenclature database: 4.2.1.129
BRENDA, the Enzyme Database: 4.2.1.129

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