KEGG   ENZYME: 4.2.1.130Help
Entry
EC 4.2.1.130                Enzyme                                 

Name
D-lactate dehydratase;
glyoxylase III;
GLO3
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-lactate hydro-lyase
Reaction(IUBMB)
(R)-lactate = 2-oxopropanal + H2O [RN:R09796]
Reaction(KEGG)
Substrate
(R)-lactate [CPD:C00256]
Product
2-oxopropanal [CPD:C00546];
H2O [CPD:C00001]
Comment
The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).
History
EC 4.2.1.130 created 2011
Pathway
ec00620  Pyruvate metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K05523  D-lactate dehydratase / protein deglycase
K18881  D-lactate dehydratase
K22211  D-lactate dehydratase
Genes
RSS: 109441754
ATH: AT2G38860(YLS5) AT3G02720(DJ1D) AT3G54600(DJ1F)
ALY: ARALYDRAFT_482901(YLS5) ARALYDRAFT_671244 ARALYDRAFT_896249 ARALYDRAFT_906870
CRB: 17887335 17890045 17893619
CSAT: 104712063 104744352 104763889 104778106 104781326 104782338 104785565 104791729 104792699
EUS: EUTSA_v10010428mg EUTSA_v10016752mg EUTSA_v10021062mg
BRP: 103829987 103864103 103870900
BNA: 106352871 106410448 106446299 106453221
BOE: 106300197 106336900 106343236
THJ: 104802426 104824175 104824176
CIT: 102624325
VRA: 106776237
VAR: 108340996
CCAJ: 109799212
CAM: 101494485
LJA: Lj2g3v2475540.1(Lj2g3v2475540.1) Lj6g3v0353790.1(Lj6g3v0353790.1)
CSV: 101208672
CMO: 103494789
MCHA: 111013252
CMAX: 111492880
CMOS: 111452219
CPEP: 111788975
VVI: 100247956
SLY: 101263864
SPEN: 107011681
SOT: 102591897
CANN: 107859656
NSY: 104230336
NTO: 104106699
INI: 109167578
SIND: 105175971
HAN: 110912749
CCAV: 112515269
SOE: 110798222
DOSA: Os04t0671700-01(Os04g0671700) Os11t0591550-00(Os11g0591550)
OBR: 102700620
BDI: 100841497
ATS: 109758946(LOC109758946) 109776890(LOC109776890)
ZMA: 100280536
PDA: 103717548
MUS: 103978686
DCT: 110107083
PEQ: 110033908
ATR: 18437741
PPP: 112287601
APRO: F751_5969
SCE: YDR533C(HSP31) YMR322C(SNO4) YOR391C(HSP33) YPL280W(HSP32)
KMX: KLMA_80019(HSP31)
TBL: TBLA_0H02460(TBLA0H02460) TBLA_0H02470(TBLA0H02470)
TDL: TDEL_0F00110(TDEL0F00110)
KAF: KAFR_0C00500(KAFR0C00500) KAFR_0I02470(KAFR0I02470) KAFR_0K01480(KAFR0K01480)
CAL: CAALFM_C302610CA(GLX3)
SLB: AWJ20_5029(HSP31)
SSCK: SPSK_04538
ANG: ANI_1_1122094(An11g08940)
PBN: PADG_11179(PADG_00973)
ABE: ARB_05407
TVE: TRV_03863
MGL: MGL_4192
ECO: b1967(hchA)
ECJ: JW1950(hchA)
ECD: ECDH10B_2110(hchA)
EBW: BWG_1768(hchA)
ECOK: ECMDS42_1594(hchA)
ECE: Z3059(yedU)
ECS: ECs2705
ECF: ECH74115_2746(hchA)
ETW: ECSP_2573(hchA)
EOI: ECO111_2546(hchA)
EOH: ECO103_2215(hchA)
ECOO: ECRM13514_2522(yedU)
ECOH: ECRM13516_2449(yedU)
ECG: E2348C_2078(hchA)
EOK: G2583_2417(hchA)
ESO: O3O_15850
ESM: O3M_09740
ESL: O3K_09775
ECW: EcE24377A_2198(hchA)
ELH: ETEC_2067
ECC: c2385(yedU)
ECP: ECP_1900
ECI: UTI89_C2166(hchA)
ECV: APECO1_1002(hchA)
ECX: EcHS_A2068(hchA)
ECM: EcSMS35_1218(hchA)
ECY: ECSE_2196
ECR: ECIAI1_2047(hchA)
ECQ: ECED1_2232(hchA)
ECK: EC55989_2193(hchA)
ECT: ECIAI39_1090(hchA)
EOC: CE10_2245(hchA)
EUM: ECUMN_2258(hchA)
ECZ: ECS88_2019(hchA)
ELO: EC042_2123(hchA)
ESE: ECSF_1816
EBR: ECB_01882(yedU)
EBD: ECBD_1680
EKF: KO11_12890(hchA)
EAB: ECABU_c22250(hchA)
EDJ: ECDH1ME8569_1907(hchA)
EIH: ECOK1_2080(hchA)
ENA: ECNA114_1913(yedU)
ELW: ECW_m2139(hchA)
ELL: WFL_10490(hchA)
ELC: i14_2198(yedU)
ELD: i02_2198(yedU)
ELP: P12B_c1056(hchA)
EBL: ECD_01882(hchA)
ELF: LF82_0965(hchA)
ECOI: ECOPMV1_02055(hchA)
ECOJ: P423_10675
ECOS: EC958_2231(hchA)
EFE: EFER_1951(hchA)
EAL: EAKF1_ch4074c(hchA)
SFL: SF2014(yedU)
SFX: S2111(yedU)
SFV: SFV_2012(yedU)
SFE: SFxv_2246(hchA)
SFN: SFy_2882
SFS: SFyv_2948
SFT: NCTC1_02190(yedU)
SSN: SSON_2023(yedU)
SBC: SbBS512_E0916(hchA)
EAE: EAE_21665
EAR: CCG29602
SMAF: D781_2748
SMW: SMWW4_v1c32350(hchA)
SMAR: SM39_2702
SERF: L085_12445
ETA: ETA_30440(hchA)
EPY: EpC_32470(hchA)
EPR: EPYR_03495(yedU)
EAM: EAMY_3249(yedU)
EAY: EAM_0353(hchA)
ERJ: EJP617_07320(yedU)
PAM: PANA_1765(hchA)
PLF: PANA5342_2437(hchA)
PAJ: PAJ_1107(hchA)
ETR: ETAE_2048(hchA)
ETD: ETAF_1847(hchA)
ETE: ETEE_0036(hchA)
PSHI: SAMEA2665130_1829(hchA)
SML: Smlt1840
SMT: Smal_1576
SMZ: SMD_1773(hchA)
VTA: B1328 B1336(hchA)
PAE: PA1135
PAEV: N297_1175(hchA)
PAEI: N296_1175(hchA)
PAU: PA14_49710(yedU)
PNC: NCGM2_2007(yedU)
PAEB: NCGM1900_1460(yedU)
PAEP: PA1S_20210
PAEM: U769_20085
PAEL: T223_21385
PAEG: AI22_13740
PAEC: M802_1171(hchA)
PAEO: M801_1175(hchA)
PMK: MDS_2717
PFO: Pfl01_2246(yedU)
PEN: PSEEN2870
PSEM: TO66_13415
PSEC: CCOS191_3061(hchA)
PSYA: AOT82_1858
ACB: A1S_2765
ABY: ABAYE0719(hchA)
ABN: AB57_3265
ABX: ABK1_3067
ABZ: ABZJ_03197(hchA)
ABD: ABTW07_3236(hchA)
ABH: M3Q_3245
ABAD: ABD1_27110(hchA)
ABAZ: P795_3320
ABAA: IX88_16995
ACC: BDGL_002217(hchA)
ACI: ACIAD1164(hchA)
SWD: Swoo_2968
AHA: AHA_3120(hchA)
REH: H16_B1347(h16_B1347)
BCN: Bcen_5029
BCJ: BCAM0131(hchA)
BCEW: DM40_3483(hchA)
BCEO: I35_4112(hchA)
BCT: GEM_5453
BCED: DM42_5050(hchA)
BLAT: WK25_19845
BSTG: WT74_24065
DAC: Daci_2046
SHZ: shn_04630
BID: Bind_2506
PAMN: JCM7685_0332(hchA)
GXY: GLX_23440
KEU: S101446_03111(hchA)
SAU: SA0509
SAV: SAV0551
SAW: SAHV_0549
SAM: MW0506
SAS: SAS0509
SAR: SAR0556
SAC: SACOL0597
SAE: NWMN_0513
SAD: SAAV_0514
SUE: SAOV_0586
SUC: ECTR2_505
SUZ: MS7_0541
SUG: SAPIG0626
SAUA: SAAG_00969
SAUE: RSAU_000503(hchA)
SAUS: SA40_0491
SAUU: SA957_0506
SAUG: SA268_0504
SAUT: SAI1T1_2004220(hchA)
SAUJ: SAI2T2_1004220(hchA)
SAUK: SAI3T3_1004220(hchA)
SAUQ: SAI4T8_1004220(hchA)
SAUV: SAI7S6_1004210(hchA)
SAUW: SAI5S5_1004190(hchA)
SAUX: SAI6T6_1004200(hchA)
SAUY: SAI8T7_1004210(hchA)
SAUF: X998_0592
SAB: SAB0502
SAUB: C248_0626
SAUM: BN843_5440
SAUC: CA347_567
SAUR: SABB_00602(hchA)
SAUI: AZ30_02790
SAUD: CH52_03000
SAMS: NI36_02740
SPAS: STP1_1532(hchA)
AIN: Acin_1683
MAB: MAB_1932c
MABB: MASS_1920
MCHE: BB28_10055
MSTE: MSTE_01869
SALS: SLNWT_1739
SERJ: SGUI_2126
PSEE: FRP1_13125
PSEH: XF36_09380
RAI: RA0C_1004
RAR: RIA_1482
RAG: B739_1117
RAE: G148_0856
RAT: M949_1586
WIN: WPG_2158
FBU: UJ101_01147(hchA)
 » show all
Taxonomy
Reference
1  [PMID:24302734]
  Authors
Hasim S, Hussin NA, Alomar F, Bidasee KR, Nickerson KW, Wilson MA
  Title
A glutathione-independent glyoxalase of the DJ-1 superfamily plays an important role in managing metabolically generated methylglyoxal in Candida albicans.
  Journal
J Biol Chem 289:1662-74 (2014)
DOI:10.1074/jbc.M113.505784
  Sequence
Reference
2  [PMID:24758716]
  Authors
Zhao Q, Su Y, Wang Z, Chen C, Wu T, Huang Y
  Title
Identification of glutathione (GSH)-independent glyoxalase III from Schizosaccharomyces pombe.
  Journal
BMC Evol Biol 14:86 (2014)
DOI:10.1186/1471-2148-14-86
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.130
IUBMB Enzyme Nomenclature: 4.2.1.130
ExPASy - ENZYME nomenclature database: 4.2.1.130
BRENDA, the Enzyme Database: 4.2.1.130

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