KEGG   ENZYME: 4.2.1.132Help
Entry
EC 4.2.1.132                Enzyme                                 

Name
2-hydroxyhexa-2,4-dienoate hydratase;
tesE (gene name);
hsaE (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxohexanoate hydro-lyase [(2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming]
Reaction(IUBMB)
4-hydroxy-2-oxohexanoate = (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O [RN:R09960]
Reaction(KEGG)
R09960;
(other) R05864
Show
Substrate
4-hydroxy-2-oxohexanoate [CPD:C06762]
Product
(2Z,4Z)-2-hydroxyhexa-2,4-dienoate [CPD:C20240];
H2O [CPD:C00001]
Comment
This enzyme catalyses a late step in the bacterial steroid degradation pathway. The product, 4-hydroxy-2-oxohexanoate, forms a 2-hydroxy-4-hex-2-enolactone under acidic conditions.
History
EC 4.2.1.132 created 2012
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18364  2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase
Genes
PGE: LG71_12240
PLUM: A4R40_11035
PSD: DSC_09160 DSC_09365
PRE: PCA10_13820 PCA10_p0350(carD)
PPSE: BN5_3620(nahL)
PCQ: PcP3B5_25700(tesE_1)
PPI: ND086(nahL)
PPUT: L483_14065
PPUN: PP4_27260
PPJ: RK21_04237
PPUU: PputUW4_01660(mhpD)
PKC: PKB_4239(xylJ)
PSET: THL1_1433
AVN: Avin_08670(xylJ) Avin_30610(lapE)
AVL: AvCA_08670(xylJ) AvCA_30610(lapE)
AVD: AvCA6_08670(xylJ) AvCA6_30610(lapE)
SPL: Spea_2118
SHL: Shal_2090
SWD: Swoo_1392
PHA: PSHAa2141(xylJ)
PTN: PTRA_a2594(bphH)
PNG: PNIG_a2788(bphH)
CYQ: Q91_0508
CYY: CPC19_10515(dmpE)
AEH: Mlg_2460
APAC: S7S_06990
TBN: TBH_C0928
GPB: HDN1F_27090(tesE)
RPI: Rpic_4620
RIN: ACS15_4354(dmpE)
REH: H16_B0548(mhpD1) H16_B0597(bphH)
CNC: CNE_2c04940(mhpD) CNE_2c05420(xylJ2) CNE_BB1p11990(xylJ1) CNE_BB1p13280(xylJ2)
RME: Rmet_1321(xylJ)
CTI: RALTA_B0401(mhpD)
BCJ: BCAM1613
BCEN: DM39_3383(dmpE) DM39_4834(dmpE)
BCEO: I35_5473
BCED: DM42_4993(dmpE) DM42_6345(dmpE)
BMEC: WJ16_26790
BXE: Bxe_C1189(bphH)
BXB: DR64_8616(dmpE)
BFN: OI25_4589(dmpE)
PARB: CJU94_37870(dmpE) CJU94_38115(dmpE)
PNA: Pnap_4144
AJS: Ajs_0222
VEI: Veis_2785
VBO: CKY39_28505(dmpE)
CTES: O987_07740
SIMP: C6571_13615(dmpE)
MELA: C6568_07860(dmpE)
JAG: GJA_236(xylJ)
LCH: Lcho_3343
DEY: HYN24_14130(dmpE) HYN24_14215(dmpE)
AZO: azo1853(lapE) azo2434(nahL)
THK: CCZ27_10770(dmpE) CCZ27_16275(dmpE)
ARC: ABLL_2444
NAR: Saro_3689
SGI: SGRAN_1581(mhpD)
SPHM: G432_01985
SSAN: NX02_12710
SPKC: KC8_03560
SJP: SJA_C1-11870(mhpD)
SPHB: EP837_03394(bphH)
SINB: SIDU_08330
SFLA: SPHFLASMR4Y_02368(tesE)
 » show all
Taxonomy
Reference
1  [PMID:16151114]
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.132
IUBMB Enzyme Nomenclature: 4.2.1.132
ExPASy - ENZYME nomenclature database: 4.2.1.132
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.132
BRENDA, the Enzyme Database: 4.2.1.132

DBGET integrated database retrieval system