KEGG   ENZYME: 4.2.1.138Help
Entry
EC 4.2.1.138                Enzyme                                 

Name
(+)-caryolan-1-ol synthase;
GcoA
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(+)-beta-caryophyllene hydrolase [cyclizing, (+)-caryolan-1-ol-forming]
Reaction(IUBMB)
(+)-beta-caryophyllene + H2O = (+)-caryolan-1-ol [RN:R09835]
Reaction(KEGG)
Substrate
(+)-beta-caryophyllene [CPD:C19973];
H2O [CPD:C00001]
Product
(+)-caryolan-1-ol [CPD:C19974]
Comment
A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-beta-caryophyllene synthase].
History
EC 4.2.1.138 created 2011 as EC 3.7.1.15, transferred 2013 to EC 4.2.1.138
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18111  (+)-beta-caryophyllene/(+)-caryolan-1-ol synthase
Genes
SGR: SGR_2079
SGB: WQO_25120
SSX: SACTE_4655
SFI: SFUL_5260
SCZ: ABE83_10275
SVU: B1H20_25705
KAB: B7C62_26245
Taxonomy
Reference
1  [PMID:21693706]
  Authors
Nakano C, Horinouchi S, Ohnishi Y
  Title
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus.
  Journal
J Biol Chem 286:27980-7 (2011)
DOI:10.1074/jbc.M111.265652
  Sequence
[sgr:SGR_2079]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.138
IUBMB Enzyme Nomenclature: 4.2.1.138
ExPASy - ENZYME nomenclature database: 4.2.1.138
BRENDA, the Enzyme Database: 4.2.1.138

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