KEGG   ENZYME: 4.2.1.152Help
Entry
EC 4.2.1.152                Enzyme                                 

Name
hydroperoxy icosatetraenoate dehydratase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)
Reaction(IUBMB)
a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O [RN:R10761]
Reaction(KEGG)
Substrate
hydroperoxyicosatetraenoate [CPD:C20832]
Product
oxoicosatetraenoate [CPD:C20833];
H2O [CPD:C00001]
Comment
Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.
History
EC 4.2.1.152 created 2014
Orthology
K18684  hydroperoxy icosatetraenoate dehydratase/isomerase
Genes
HSA: 59344(ALOXE3)
PTR: 455102(ALOXE3)
PPS: 100972484(ALOXE3)
GGO: 101143347(ALOXE3)
PON: 100451294(ALOXE3)
NLE: 100586195(ALOXE3)
MCC: 716840(ALOXE3)
MCF: 102115677(ALOXE3)
CSAB: 103242340(ALOXE3)
RRO: 104661680(ALOXE3)
RBB: 108514454(ALOXE3)
CJC: 100410917(ALOXE3)
SBQ: 101049071(ALOXE3)
MMU: 23801(Aloxe3)
RNO: 287424(Aloxe3)
CGE: 100754187(Aloxe3)
NGI: 103752100(Aloxe3)
HGL: 101709560(Aloxe3)
CCAN: 109693886(Aloxe3)
OCU: 100342323(ALOXE3)
TUP: 102493953(ALOXE3)
CFA: 489487(ALOXE3)
AML: 100479842(ALOXE3)
UMR: 103660488(ALOXE3)
ORO: 101371570(ALOXE3)
FCA: 101101515(ALOXE3)
PTG: 102957798(ALOXE3) 102959712
AJU: 106972447(ALOXE3)
BTA: 517001(ALOXE3)
BOM: 102276466(ALOXE3)
BIU: 109573427(ALOXE3)
PHD: 102341938(ALOXE3)
CHX: 102172190 102173227(ALOXE3)
OAS: 101121693(ALOXE3)
SSC: 100511043(ALOXE3)
CFR: 102517831(ALOXE3)
CDK: 105103062(ALOXE3)
BACU: 102998369(ALOXE3)
OOR: 101281475
ECB: 100062351(ALOXE3)
EPZ: 103564279(ALOXE3)
EAI: 106844234(ALOXE3)
MYB: 102250064(ALOXE3)
MYD: 102763007(ALOXE3)
HAI: 109395102(ALOXE3)
RSS: 109454410(ALOXE3)
PALE: 102893198(ALOXE3)
LAV: 100671875(ALOXE3)
TMU: 101348431
MDO: 100014706(ALOXE3)
SHR: 100934620(ALOXE3)
ACYG: 106049819
GFR: 102043765(ALOXE3)
FAB: 101818404(ALOXE3)
PMAJ: 107198965
CCAE: 111942155
AAM: 106500300(ALOXE3)
AMJ: 102558959(ALOXE3) 102564354
PSS: 102450844
CMY: 102945124
XTR: 100494252(alox15b)
DRE: 794132(si:dkey-17e16.9)
SRX: 107756080
SGH: 107548144
NFU: 107374447
HCQ: 109527797
MALB: 109953467
SFM: 108925302
LCM: 102352103
 » show all
Taxonomy
Reference
1  [PMID:12881489]
  Authors
Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR
  Title
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
  Journal
Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100
  Sequence
[hsa:59344]
Reference
2  [PMID:17045234]
  Authors
Yu Z, Schneider C, Boeglin WE, Brash AR
  Title
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
  Journal
Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002
  Sequence
[hsa:59344] [mmu:23801]
Reference
3  [PMID:20921226]
  Authors
Zheng Y, Brash AR
  Title
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
  Journal
J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374
  Sequence
[hsa:59344]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.152
IUBMB Enzyme Nomenclature: 4.2.1.152
ExPASy - ENZYME nomenclature database: 4.2.1.152
BRENDA, the Enzyme Database: 4.2.1.152

KEGG   ENZYME: 5.4.4.7Help
Entry
EC 5.4.4.7                  Enzyme                                 

Name
hydroperoxy icosatetraenoate isomerase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)
Class
Isomerases;
Intramolecular transferases;
Transferring hydroxy groups
BRITE hierarchy
Sysname
hydroperoxyicosatetraenoate hydroxymutase
Reaction(IUBMB)
a hydroperoxyicosatetraenoate = a hydroxyepoxyicosatrienoate [RN:R10766]
Reaction(KEGG)
Substrate
hydroperoxyicosatetraenoate [CPD:C20832]
Product
hydroxyepoxyicosatrienoate [CPD:C20837]
Comment
Binds Fe2+. The enzyme from mammals accepts a range of hydroperoxyicosatetraenoates producing one or several different hydroxyepoxyicosatrienoates. The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate [1]. The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate [2]. The enzymes also have the activity of EC 4.2.1.152, hydroperoxy icosatetraenoate dehydratase.
History
EC 5.4.4.7 created 2014
Orthology
K18684  hydroperoxy icosatetraenoate dehydratase/isomerase
Genes
HSA: 59344(ALOXE3)
PTR: 455102(ALOXE3)
PPS: 100972484(ALOXE3)
GGO: 101143347(ALOXE3)
PON: 100451294(ALOXE3)
NLE: 100586195(ALOXE3)
MCC: 716840(ALOXE3)
MCF: 102115677(ALOXE3)
CSAB: 103242340(ALOXE3)
RRO: 104661680(ALOXE3)
RBB: 108514454(ALOXE3)
CJC: 100410917(ALOXE3)
SBQ: 101049071(ALOXE3)
MMU: 23801(Aloxe3)
RNO: 287424(Aloxe3)
CGE: 100754187(Aloxe3)
NGI: 103752100(Aloxe3)
HGL: 101709560(Aloxe3)
CCAN: 109693886(Aloxe3)
OCU: 100342323(ALOXE3)
TUP: 102493953(ALOXE3)
CFA: 489487(ALOXE3)
AML: 100479842(ALOXE3)
UMR: 103660488(ALOXE3)
ORO: 101371570(ALOXE3)
FCA: 101101515(ALOXE3)
PTG: 102957798(ALOXE3) 102959712
AJU: 106972447(ALOXE3)
BTA: 517001(ALOXE3)
BOM: 102276466(ALOXE3)
BIU: 109573427(ALOXE3)
PHD: 102341938(ALOXE3)
CHX: 102172190 102173227(ALOXE3)
OAS: 101121693(ALOXE3)
SSC: 100511043(ALOXE3)
CFR: 102517831(ALOXE3)
CDK: 105103062(ALOXE3)
BACU: 102998369(ALOXE3)
OOR: 101281475
ECB: 100062351(ALOXE3)
EPZ: 103564279(ALOXE3)
EAI: 106844234(ALOXE3)
MYB: 102250064(ALOXE3)
MYD: 102763007(ALOXE3)
HAI: 109395102(ALOXE3)
RSS: 109454410(ALOXE3)
PALE: 102893198(ALOXE3)
LAV: 100671875(ALOXE3)
TMU: 101348431
MDO: 100014706(ALOXE3)
SHR: 100934620(ALOXE3)
ACYG: 106049819
GFR: 102043765(ALOXE3)
FAB: 101818404(ALOXE3)
PMAJ: 107198965
CCAE: 111942155
AAM: 106500300(ALOXE3)
AMJ: 102558959(ALOXE3) 102564354
PSS: 102450844
CMY: 102945124
XTR: 100494252(alox15b)
DRE: 794132(si:dkey-17e16.9)
SRX: 107756080
SGH: 107548144
NFU: 107374447
HCQ: 109527797
MALB: 109953467
SFM: 108925302
LCM: 102352103
 » show all
Taxonomy
Reference
1  [PMID:12881489]
  Authors
Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR
  Title
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
  Journal
Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100
  Sequence
[hsa:59344]
Reference
2  [PMID:17045234]
  Authors
Yu Z, Schneider C, Boeglin WE, Brash AR
  Title
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
  Journal
Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002
  Sequence
[hsa:59344] [mmu:23801]
Reference
3  [PMID:20921226]
  Authors
Zheng Y, Brash AR
  Title
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
  Journal
J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374
  Sequence
[hsa:59344]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.4.7
IUBMB Enzyme Nomenclature: 5.4.4.7
ExPASy - ENZYME nomenclature database: 5.4.4.7
BRENDA, the Enzyme Database: 5.4.4.7

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