Entry |
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Name |
propanediol dehydratase;
meso-2,3-butanediol dehydrase;
diol dehydratase;
DL-1,2-propanediol hydro-lyase;
diol dehydrase;
adenosylcobalamin-dependent diol dehydratase;
propanediol dehydrase;
coenzyme B12-dependent diol dehydrase;
1,2-propanediol dehydratase;
dioldehydratase;
propane-1,2-diol hydro-lyase;
RiDD
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Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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Sysname |
propane-1,2-diol hydro-lyase (propanal-forming)
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Reaction(IUBMB) |
propane-1,2-diol = propanal + H2O [RN: R02376]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Two different forms of the enzyme have been described. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme. The cobamide-dependent enzyme has been shown to also dehydrate ethylene glycol to acetaldehyde.
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History |
EC 4.2.1.28 created 1965
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Pathway |
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Orthology |
K01699 | propanediol dehydratase large subunit |
K13919 | propanediol dehydratase medium subunit |
K13920 | propanediol dehydratase small subunit |
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Genes |
» show all
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Reference |
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Authors |
ABELES RH, LEE HA Jr. |
Title |
An intramolecular oxidation-reduction requiring a cobamide coenzyme. |
Journal |
J Biol Chem 236:2347-50 (1961) |
Reference |
|
Authors |
LEE HA Jr, ABELES RH. |
Title |
Purification and properties of dioldehydrase, and enzyme requiring a cobamide coenzyme. |
Journal |
J Biol Chem 238:2367-73 (1963) |
Reference |
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Authors |
Forage RG, Foster MA. |
Title |
Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases. |
Journal |
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Reference |
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Authors |
LaMattina JW, Keul ND, Reitzer P, Kapoor S, Galzerani F, Koch DJ, Gouvea IE, Lanzilotta WN |
Title |
1,2-Propanediol Dehydration in Roseburia inulinivorans: STRUCTURAL BASIS FOR SUBSTRATE AND ENANTIOMER SELECTIVITY. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 4.2.1.28 |
ExPASy - ENZYME nomenclature database: | 4.2.1.28 |
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