KEGG   ENZYME: 4.2.1.45Help
Entry
EC 4.2.1.45                 Enzyme                                 

Name
CDP-glucose 4,6-dehydratase;
cytidine diphosphoglucose oxidoreductase;
CDP-glucose 4,6-hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)
Reaction(IUBMB)
CDP-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O [RN:R02426]
Reaction(KEGG)
Substrate
CDP-glucose [CPD:C00501]
Product
CDP-4-dehydro-6-deoxy-D-glucose [CPD:C01219];
H2O [CPD:C00001]
Comment
Requires bound NAD+.
History
EC 4.2.1.45 created 1972
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
Orthology
K01709  CDP-glucose 4,6-dehydratase
Genes
STY: STY2301(rfbG)
STT: t0781(rfbG)
SEX: STBHUCCB_8330
SENT: TY21A_03960
STM: STM2091(rfbG)
SEO: STM14_2585(rfbG)
SEV: STMMW_21221
SEY: SL1344_2068(rfbG)
SEM: STMDT12_C21130
SEJ: STMUK_2121(rfbG)
SEB: STM474_2176(rfbG)
SEF: UMN798_2259(rfbG)
SENR: STMDT2_20651(rfbG)
SEND: DT104_21501(rfbG)
SENI: CY43_11280
SPT: SPA0775(rfbG)
SEK: SSPA0729
SEH: SeHA_C2317(rfbG)
SHB: SU5_02685
SEE: SNSL254_A2273(rfbG)
SEW: SeSA_A2324(rfbG)
SEA: SeAg_B2216(rfbG)
SENS: Q786_10325
SED: SeD_A2431(rfbG)
SEG: SG2122(rfbG)
SEL: SPUL_0806(rfbG)
SEGA: SPUCDC_0806(rfbG)
SET: SEN2087(rfbG)
SENA: AU38_10550
SENO: AU37_10560
SENV: AU39_10560
SENQ: AU40_11815
SENL: IY59_10845
SEEP: I137_03620
SENB: BN855_21800(rfbG)
YPK: y1069
YPH: YPC_3393
YPA: YPA_2606
YPN: YPN_0976
YPM: YP_0816(wcaG1)
YPZ: YPZ3_2743
YPD: YPD4_2731
YPX: YPD8_2722
YPW: CH59_2951(rfbG)
YPJ: CH55_1692(rfbG)
YPV: BZ15_413(rfbG)
YPL: CH46_1985(rfbG)
YPS: YPTB1000(ddhB)
YPO: BZ17_1548(rfbG)
YPI: YpsIP31758_3050(ddhB)
YPY: YPK_3190
YPB: YPTS_1043
YPQ: DJ40_1359(rfbG)
YPU: BZ21_243(rfbG)
YPR: BZ20_1046(rfbG)
YPC: BZ23_519(rfbG)
YPF: BZ19_357(rfbG)
YEN: YE3086(ddhB)
YEL: LC20_00109(rfbG)
YEW: CH47_2461(rfbG)
YRO: CH64_2962(rfbG)
YMA: DA391_20635(rfbG)
SERA: Ser39006_021620(rfbG)
ECA: ECA1423(rfbG)
PATR: EV46_07205
PATO: GZ59_14620(rfbG)
VAN: VAA_02489
VAU: VANGNB10_cI2516c(rfbG)
VTA: A2993(rfbG)
VFI: VF_0183(ddhB)
PPF: Pput_1480
PPI: YSA_08054
PPUT: L483_24200
PPUN: PP4_13900(ddhB)
PAMG: BKM19_007325(rfbG)
PAVL: BKM03_06260(rfbG)
PFL: PFL_5095(rfbG)
PFO: Pfl01_1511(rfbG)
PFW: PF1751_v1c16350(rfbG)
PMAN: OU5_5127
PPUU: PputUW4_03902(rfbG)
PSES: PSCI_3457(rfbG)
PSEM: TO66_08025
PSEC: CCOS191_1481(rfbG)
PSOS: POS17_1644(rfbG)
AVN: Avin_27770(rfbG)
AVL: AvCA_27770(rfbG)
AVD: AvCA6_27770(rfbG)
SDN: Sden_2656
SPSW: Sps_03723
PAT: Patl_3062
AMAG: I533_07855
PIN: Ping_0774
LLO: LLO_0219(rfbG)
LSH: CAB17_05155(rfbG)
TMC: LMI_3127(rfbG)
TCX: Tcr_1689
MEJ: Q7A_2393(rfbG)
TIG: THII_1696
GAI: IMCC3135_26280(rfbG)
AHA: AHA_4165(rfbG)
ADH: CK627_03080(rfbG)
SOK: D0B54_15020(rfbG)
SLIM: SCL_1720
GPB: HDN1F_26610(ddhB)
CVI: CV_3892(rfbG)
CHRO: CXB49_01900(rfbG) CXB49_18015(rfbG)
LHK: LHK_02715(rfbG)
RPI: Rpic_4735
RIN: ACS15_5102(rfbG)
REH: H16_A2896(h16_A2896)
BPS: BPSS0420(rfbG)
BPM: BURPS1710b_A1962(rfbG)
BPL: BURPS1106A_A0569(rfbG)
BPD: BURPS668_A0663(rfbG)
BPSE: BDL_3647(rfbG)
BPSM: BBQ_5777(rfbG)
BPSU: BBN_3819(rfbG)
BPSD: BBX_5484(rfbG)
BPZ: BP1026B_II0471(rfbG)
BPK: BBK_5625(rfbG)
BPSH: DR55_4933(rfbG)
BPSA: BBU_5628(rfbG)
BPSO: X996_4684(rfbG)
BUT: X994_4201(rfbG)
BTE: BTH_II1983(rfbG)
BTQ: BTQ_5264(rfbG)
BTJ: BTJ_3896(rfbG)
BTZ: BTL_4750(rfbG)
BTV: BTHA_5477(rfbG)
BTHE: BTN_4389(rfbG)
BTHM: BTRA_4656(rfbG)
BTHA: DR62_4438
BTHL: BG87_4722(rfbG)
BOK: DM82_4499(rfbG)
PHS: C2L64_13935(rfbG)
PTER: C2L65_12095(rfbG)
PNE: Pnec_0332
POH: DPM16_01665(rfbG)
PPNO: DA70_24445
HYF: DTO96_101654(rfbG)
BAV: BAV1254(rfbG)
BOZ: DBV39_04140(rfbG)
ASW: CVS48_16740(rfbG)
ODI: ODI_R2114
RFR: Rfer_1251
POL: Bpro_4010
VEI: Veis_4419
VBO: CKY39_03870(rfbG)
VAM: C4F17_15415(rfbG)
CBX: Cenrod_1801(rfbG)
CBAA: SRAA_0827
CBAB: SMCB_1244(rfbG)
HAR: HEAR1134(rfbG)
HSE: Hsero_4408(rfbG)
HRB: Hrubri_4298(rfbG) Hrubri_4345(rfbG)
HEE: hmeg3_01990(rfbG) hmeg3_21265(rfbG)
MASS: CR152_14880(rfbG)
PBH: AAW51_4308(rfbG)
TBD: Tbd_1880
SLT: Slit_2898
GCA: Galf_2849
DSU: Dsui_0072
DAR: Daro_1257
AZA: AZKH_1441
BPRC: D521_0315
SUA: Saut_1504
SULR: B649_09970
CCQ: N149_1083
CCOF: VC76_05605(rfbG)
CGRA: CGRAC_1924
CHYO: CHH_0050
SMUL: SMUL_2478(rfbG)
SHAL: SHALO_2226
SULJ: SJPD1_2234
SUN: SUN_2138
GSK: KN400_2959(ddhB)
GUR: Gura_3789
GLO: Glov_0783
GBM: Gbem_0856(ddhB)
GEO: Geob_2125(ddhB)
GEM: GM21_3401
PCA: Pcar_1131(ddhB)
PPD: Ppro_3349
DVU: DVU0073
DVL: Dvul_2888
DVM: DvMF_1909
DDE: Dde_3695
DDS: Ddes_0876
DEF: CNY67_09330(rfbG) CNY67_09800(rfbG)
DTR: RSDT_0483(rfbG)
DAS: Daes_3271
PPRF: DPRO_1451(rfbG)
DBA: Dbac_1872
DOL: Dole_1960
SCL: sce4869
SAT: SYN_02648
BBA: Bd1665(rfbG)
BBAT: Bdt_1654(rfbG)
BBW: BDW_05875
BBAC: EP01_04515
BMX: BMS_0382(rfbG)
PLA: Plav_3352
RBS: RHODOSMS8_00396(rfbG)
SME: SM_b21417(ddhB)
SMX: SM11_pD0362(ddhB)
SMI: BN406_05436(ddhB)
SMEL: SM2011_b21417(ddhB)
SMER: DU99_27320
RHI: NGR_c24350(ddhB)
SFD: USDA257_c48650(rfbG)
SAME: SAMCFNEI73_Ch2771(rfbG)
EAD: OV14_3959(ddhB)
AVI: Avi_0627(rfbG)
REP: IE4803_CH00258(rfbG)
REI: IE4771_CH00259(rfbG)
RLE: RL0245
RLG: Rleg_4510
RHL: LPU83_0087(ddhB)
RHN: AMJ98_CH00238(rfbG)
RHX: AMK02_CH00239(rfbG)
BJA: bll5979
BRS: S23_22470
BOT: CIT37_24235(rfbG)
RPA: RPA4049(rfbG)
RPE: RPE_4254
VGO: GJW-30_1_04051(rfbG)
AZC: AZC_3479
MEX: Mext_0847
MEA: Mex_1p0613(rfbG)
MDI: METDI0984(rfbG)
MCH: Mchl_0806
MPO: Mpop_0771
MET: M446_4030
MNO: Mnod_3176
META: Y590_03155
METD: C0214_03550(rfbG)
HMC: HYPMC_1823(rfbG)
MSC: BN69_1215
BRN: D1F64_10650(rfbG)
HDI: HDIA_0884(rfbG)
CAK: Caul_2715
PZU: PHZ_c0495
PHB: HYN04_10595(rfbG)
PGL: PGA2_c18820(rfbG)
PHP: PhaeoP97_00697(rfbG)
LABR: CHH27_20945(rfbG)
YPAC: CEW88_23435(rfbG)
SULZ: C1J03_20495(rfbG)
HBA: Hbal_2140
SPHM: G432_10870
SPKC: KC8_08060
SPHC: CVN68_01785(rfbG)
SPMI: K663_12450
SINB: SIDU_00050
SHYD: CJD35_11220(rfbG)
SYA: A6768_14525(rfbG)
RDI: CMV14_06215(rfbG)
ACR: Acry_0592
AMV: ACMV_06670(rfbG)
RCE: RC1_3779(rfbG)
RPM: RSPPHO_01177(rfbG)
MGY: MGMSRv2__3398(rfbG)
MAGN: WV31_13040
THAC: CSC3H3_19015(rfbG)
TII: DY252_10830(rfbG)
MAGQ: MGMAQ_3829(rfbG)
BSR: I33_0820(yfnG)
BSL: A7A1_1771
BSH: BSU6051_07280(yfnG)
BSUT: BSUB_00802(yfnG)
BSUL: BSUA_00802(yfnG)
BSUS: Q433_04100
BSS: BSUW23_03705(yfnG)
BST: GYO_0990(yfnG)
BSO: BSNT_07115(yfnG)
BSQ: B657_07280(yfnG)
BSX: C663_0754
BAY: RBAM_007530(yfnG)
BAQ: BACAU_0721(yfnG)
BYA: BANAU_0668(yfnG)
BAMP: B938_03570
BAML: BAM5036_0666(yfnG)
BAMA: RBAU_0725(yfnG)
BAMN: BASU_0702(yfnG)
BAMB: BAPNAU_0677(yfnG)
BAMT: AJ82_04175
BAMY: V529_06890(yfnG)
BMP: NG74_00742(rfbG)
BAO: BAMF_0698(yfnG)
BAZ: BAMTA208_03300(yfnG)
BQL: LL3_00750(yfnG)
BXH: BAXH7_00695(yfnG)
BQY: MUS_0737(rfbG)
BAMI: KSO_016060
BAMC: U471_07320
BAMF: U722_03700
BCA: BCE_3396
BCZ: BCE33L3070(rfbG)
BCR: BCAH187_A3400(rfbG)
BCB: BCB4264_A3374(rfbG1) BCB4264_A3529(rfbG2)
BCG: BCG9842_B1702(rfbG_1)
BCQ: BCQ_3172(rfbG)
BNC: BCN_3190
BCER: BCK_18310
BTB: BMB171_C3048(rfbG_2) BMB171_C3190(rfbG_1)
BTC: CT43_CH3289(rfbG_2)
BTM: MC28_2503
BTG: BTB_c34220(rfbG)
BTI: BTG_01915
BWW: bwei_1561(rfbG)
BMYO: BG05_2635(rfbG)
BMYC: DJ92_4412(rfbG)
BPU: BPUM_0677
BPUM: BW16_03595
BPUS: UP12_03720
BJS: MY9_0821
BACW: QR42_03510
BACP: SB24_06120
BACB: OY17_06390
BACY: QF06_02545
BACL: BS34A_08280(yfnG)
BALM: BsLM_0768
BKW: BkAM31D_07645(rfbG)
BBE: BBR47_17460(ddhB)
PPM: PPSC2_23010(ddhB)
PPO: PPM_4567(ddhB)
PPOL: X809_24810
PMW: B2K_23195
PLV: ERIC2_c01950(rfbG)
PSAB: PSAB_18945
PRI: PRIO_3455(yfnG)
PDH: B9T62_03010(rfbG)
CBK: CLL_A2337(rfbG)
CBEI: LF65_02935
CSR: Cspa_c54140(rfbG)
CPAS: Clopa_3073
CPAT: CLPA_c07790(rfbG)
CPAE: CPAST_c07790(rfbG)
CSQ: CSCA_4718
CLD: CLSPO_c27890(rfbG)
CTYK: CTK_C21310
CTH: Cthe_2561
CTHD: CDO33_00680(rfbG)
ESR: ES1_22700
ESU: EUS_16950
BPB: bpr_I2312(rfbG)
BHU: bhn_I0587
ROB: CK5_01630
CSO: CLS_35590
CBOL: CGC65_03705(rfbG)
SGY: Sgly_0574
ELM: ELI_2398
BPRM: CL3_13430
BPRS: CK3_10640
MEG: DKB62_11225(rfbG)
SRI: SELR_05850(rfbG)
PUF: UFO1_4186
MIT: OCO_31050
MIA: OCU_30930
MIR: OCQ_31670
MMI: MMAR_2336(galE6)
MMAE: MMARE11_22580(galE6)
MLI: MULP_03284(galE6)
NDK: I601_0091(rfbG)
MGG: MPLG2_0091(rfbG)
SYN: slr0984(rfbG)
SYZ: MYO_13300(rfbG)
SYY: SYNGTS_0326(rfbG)
SYT: SYNGTI_0326(rfbG)
SYS: SYNPCCN_0326(rfbG)
SYQ: SYNPCCP_0326(rfbG)
SYO: C7I86_01695(rfbG)
SYC: syc1441_d(rfbG)
SYNW: SynWH8103_00506(rfbG)
THN: NK55_10630(rfbG)
PMM: PMM1203(rfbG)
PMC: P9515_07611(rfbG)
PMF: P9303_01401(rfbG)
PMJ: P9211_12911(rfbG)
PRM: EW15_2181
AMR: AM1_2189
MAR: MAE_10890(rfbG)
MPK: VL20_2436
GLJ: GKIL_1902
NSP: BMF81_02395(rfbG)
CAP: CLDAP_10490(rfbG)
PBF: CFX0092_A2655(rfbG) CFX0092_A3612(yfnG)
PUV: PUV_26320(rfbG)
WCH: wcw_0069(rfbG)
CAA: Caka_0401
PSL: Psta_4509
PIR: VN12_04505(rfbG)
PLS: VT03_17500(rfbG)
GES: VT84_07875(rfbG)
SACI: Sinac_3926
VBC: C5Q97_10055(rfbG) C5Q97_10265(rfbG)
TAZ: TREAZ_3055(rfbG)
TPI: TREPR_2374(rfbG)
LIL: LA_1632
LIE: LIF_A1318
LIC: LIC_12151(rfbG)
LMAY: DPV73_15840(rfbG)
BRM: Bmur_0130
BPW: WESB_0128
BIP: Bint_1444
ACA: ACP_0579(rfbG)
ABAS: ACPOL_2208
SUS: Acid_2249
EPO: Epro_1255(rfbG)
FVA: FV113G1_10310(rfbG)
FUL: C4N20_11260(rfbG)
BTH: BT_1350
BFR: BF1536
BVU: BVU_4030
BCAC: CGC64_13040(rfbG) CGC64_18590(rfbG)
BHF: C3V43_13595(rfbG)
PARC: CI960_11240(rfbG)
PRU: PRU_0435
ASH: AL1_18340
BLQ: L21SP5_02122(rfbG)
DFE: Dfer_4602
LBY: Lbys_2467
RUN: DR864_01120(rfbG)
FAE: FAES_5468(rfbG)
ALS: DJ013_21660(rfbG)
FBR: FBFL15_0752(rfbG)
COC: Coch_0709
CAPN: CBG49_03885(rfbG)
CSPU: CGC55_10355(rfbG)
AALG: AREALGSMS7_03238(rfbG)
CPC: Cpar_1449
CACI: CLOAM0643
SAF: SULAZ_1206(rfbG)
PMX: PERMA_1995(rfbG)
NIO: NITINOP_2253(rfbG)
NJA: NSJP_2205
MAE: Maeo_0387
MARC: AR505_0543
MLA: Mlab_1424
MPI: Mpet_1369
MPL: Mpal_2191
 » show all
Taxonomy
Reference
1  [PMID:4380946]
  Authors
Hey AE, Elbein AD.
  Title
Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase.
  Journal
J Biol Chem 241:5473-8 (1966)
Reference
2  [PMID:4288651]
  Authors
Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL.
  Title
Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3. Cytidine diphosphate D-glucose oxidoreductase.
  Journal
J Biol Chem 241:4283-7 (1966)
Reference
3  [PMID:4869560]
  Authors
Melo A, Elliott WH, Glaser L.
  Title
The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase.
  Journal
J Biol Chem 243:1467-74 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.45
IUBMB Enzyme Nomenclature: 4.2.1.45
ExPASy - ENZYME nomenclature database: 4.2.1.45
BRENDA, the Enzyme Database: 4.2.1.45
CAS: 37259-55-5

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