KEGG   ENZYME: 4.2.1.54Help
Entry
EC 4.2.1.54                 Enzyme                                 

Name
lactoyl-CoA dehydratase;
lactoyl coenzyme A dehydratase;
lactyl-coenzyme A dehydrase;
lactyl CoA dehydratase;
acrylyl coenzyme A hydratase;
lactoyl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)
Reaction(IUBMB)
(R)-lactoyl-CoA = acryloyl-CoA + H2O [RN:R02963]
Reaction(KEGG)
Substrate
(R)-lactoyl-CoA
Product
acryloyl-CoA [CPD:C00894];
H2O [CPD:C00001]
Comment
A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway).
History
EC 4.2.1.54 created 1972, modified 2012
Pathway
ec00640  Propanoate metabolism
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K20626  lactoyl-CoA dehydratase subunit alpha
K20627  lactoyl-CoA dehydratase subunit beta
Genes
CNO: NT01CX_2368(hgdB) NT01CX_2369(hgdA)
CBN: CbC4_1682 CbC4_1683
CCT: CC1_11640 CC1_11650
DOR: Desor_3092 Desor_3093
DMI: Desmer_1800 Desmer_1801
MED: MELS_0745 MELS_0746
Taxonomy
Reference
1  [PMID:14292829]
  Authors
BALDWIN RL, WOOD WA, EMERY RS.
  Title
LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE.
  Journal
Biochim Biophys Acta 97:202-13 (1965)
DOI:10.1016/0304-4165(65)90084-X
Reference
2  [PMID:6586495]
  Authors
Schweiger G, Buckel W
  Title
On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum.
  Journal
FEBS Lett 171:79-84 (1984)
DOI:10.1016/0014-5793(84)80463-9
Reference
3  [PMID:4055736]
  Authors
Kuchta RD, Abeles RH
  Title
Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase.
  Journal
J Biol Chem 260:13181-9 (1985)
  Sequence
Reference
4  [PMID:3026450]
  Authors
Kuchta RD, Hanson GR, Holmquist B, Abeles RH
  Title
Fe-S centers in lactyl-CoA dehydratase.
  Journal
Biochemistry 25:7301-7 (1986)
Reference
5  [PMID:1597194]
  Authors
Hofmeister AE, Buckel W
  Title
(R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA.
  Journal
Eur J Biochem 206:547-52 (1992)
DOI:10.1111/j.1432-1033.1992.tb16958.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.54
IUBMB Enzyme Nomenclature: 4.2.1.54
ExPASy - ENZYME nomenclature database: 4.2.1.54
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.54
BRENDA, the Enzyme Database: 4.2.1.54
CAS: 9031-12-3

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