| Entry |
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| Name |
uroporphyrinogen-III synthase;
porphobilinogenase;
uroporphyrinogen isomerase;
uroporphyrinogen III cosynthase;
URO-synthase;
hydroxymethylbilane hydro-lyase (cyclizing)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)
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| Reaction(IUBMB) |
hydroxymethylbilane = uroporphyrinogen III + H2O [RN: R03165]
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| Reaction(KEGG) |
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| Substrate |
hydroxymethylbilane [CPD: C01024]
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| Product |
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| Comment |
In the presence of EC 2.5.1.61, hydroxymethylbilane synthase, the enzyme forms uroporphyrinogen III from porphobilinogen.
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| History |
EC 4.2.1.75 created 1982
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| Pathway |
| ec00860 | Porphyrin and chlorophyll metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K01719 | uroporphyrinogen-III synthase |
| K13542 | uroporphyrinogen III methyltransferase / synthase |
| K13543 | uroporphyrinogen III methyltransferase / synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Battersby AR, Fookes CJ, Matcham GW, McDonald E. |
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| Title |
Biosynthesis of the pigments of life: formation of the macrocycle. |
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| Journal |
Nature 285:17-21 (1980) |
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| Reference |
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| Authors |
Tsai SF, Bishop DF, Desnick RJ. |
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| Title |
Purification and properties of uroporphyrinogen III synthase from human erythrocytes. |
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| Journal |
J Biol Chem 262:1268-73 (1987) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.1.75 |
| ExPASy - ENZYME nomenclature database: | 4.2.1.75 |
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