KEGG   ENZYME: 4.2.1.85Help
Entry
EC 4.2.1.85                 Enzyme                                 

Name
dimethylmaleate hydratase;
(2R,3S)-2,3-dimethylmalate hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming)
Reaction(IUBMB)
(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O [RN:R03069]
Reaction(KEGG)
Substrate
(2R,3S)-2,3-dimethylmalate [CPD:C03652]
Product
dimethylmaleate;
H2O [CPD:C00001]
Comment
Requires Fe2+. Inhibited by oxygen.
History
EC 4.2.1.85 created 1989
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20452  dimethylmaleate hydratase large subunit
K20453  dimethylmaleate hydratase small subunit
Genes
ELM: ELI_2736 ELI_2737
Taxonomy
Reference
1  [PMID:6489933]
  Authors
Kollmann-Koch A, Eggerer H.
  Title
Nicotinic acid metabolism. Dimethylmaleate hydratase.
  Journal
Hoppe Seylers Z Physiol Chem 365:847-57 (1984)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.85
IUBMB Enzyme Nomenclature: 4.2.1.85
ExPASy - ENZYME nomenclature database: 4.2.1.85
BRENDA, the Enzyme Database: 4.2.1.85
CAS: 93229-56-2

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