KEGG   ENZYME: 4.2.1.88Help
Entry
EC 4.2.1.88                 Enzyme                                 

Name
synephrine dehydratase;
syringinase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-synephrine hydro-lyase (methylamine-forming)
Reaction(IUBMB)
(R)-synephrine = (4-hydroxyphenyl)acetaldehyde + methylamine [RN:R03359]
Reaction(KEGG)
Substrate
(R)-synephrine [CPD:C01869]
Product
4-hydroxyphenylacetaldehyde [CPD:C03765];
methylamine [CPD:C00218]
Comment
Removal of H2O from (R)-synephrine produces a 2,3-enamine, which hydrolyses to the products shown in the reaction above. The enzyme from Arthrobacter synephrinum is highly specific [1].
History
EC 4.2.1.88 created 1989, modified 2012
Reference
1  [PMID:1008837]
  Authors
Veeraswamy M, Devi NA, Kutty RK, Rao PV.
  Title
Conversion of (+/-)-synephrine into p-hydroxyphenylacetaldehyde by Arthrobacter synephrinum. A novel enzymic reaction.
  Journal
Biochem J 159:807-9 (1976)
Reference
2  [PMID:3729420]
  Authors
Manne V, Kutty KR, Pillarisetti SR
  Title
Purification and properties of synephrinase from Arthrobacter synephrinum.
  Journal
Arch Biochem Biophys 248:324-34 (1986)
DOI:10.1016/0003-9861(86)90428-5
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.88
IUBMB Enzyme Nomenclature: 4.2.1.88
ExPASy - ENZYME nomenclature database: 4.2.1.88
BRENDA, the Enzyme Database: 4.2.1.88
CAS: 104118-54-9

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