KEGG   ENZYME: 4.2.1.91Help
Entry
EC 4.2.1.91                 Enzyme                                 

Name
arogenate dehydratase;
carboxycyclohexadienyl dehydratase;
L-arogenate hydro-lyase (decarboxylating)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)
Reaction(IUBMB)
L-arogenate = L-phenylalanine + H2O + CO2 [RN:R00691]
Reaction(KEGG)
R00691;
(other) R01373
Show
Substrate
L-arogenate [CPD:C00826]
Product
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
CO2 [CPD:C00011]
Comment
Also acts on prephenate and D-prephenyllactate. cf. EC 4.2.1.51, prephenate dehydratase.
History
EC 4.2.1.91 created 1992, modified 2005
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K01713  cyclohexadienyl dehydratase
K05359  arogenate/prephenate dehydratase
Genes
ATH: AT1G08250(ADT6) AT1G11790(ADT1) AT2G27820(PD1) AT3G07630(ADT2) AT3G44720(ADT4) AT5G22630(ADT5)
ALY: ARALYDRAFT_481721 ARALYDRAFT_484876 ARALYDRAFT_671592 ARALYDRAFT_888494 ARALYDRAFT_910257
CRB: 17874516 17881424 17886053 17887916 17893858 17897636 17898053
CSAT: 104698845 104703596 104706558 104706559 104710935 104736273 104737487 104739408 104739827 104744956 104752678 104755004 104755435 104764488 104770573 104770604 104780319 104786939 109125899
EUS: EUTSA_v10003028mg EUTSA_v10007886mg EUTSA_v10016085mg EUTSA_v10016681mg EUTSA_v10020951mg
BRP: 103836212 103843406 103843407 103845522 103851454 103859235 103864806 103870648 103871931 103873609
BNA: 106346426 106347647 106362165 106374925 106380293 106384611 106385680 106388896 106397056 106397471 106397482 106397484 106413870 106420031 106420042 106424259 106424312 106424342 106427864 106436926 106446738 106448758 106452944 111197794 111198643 111212716
BOE: 106307273 106309610 106310424 106319159 106327879 106329170 106332004 106336562 106343612 106343866
THJ: 104800556 104809501 104815126 104815732 104823528 104823677
CPAP: 110811555 110815588 110825169
LJA: Lj3g3v3087250.1(Lj3g3v3087250.1) Lj4g3v0149480.1(Lj4g3v0149480.1)
DOSA: Os03t0286200-01(Os03g0286200) Os04t0406600-01(Os04g0406600) Os07t0512000-01(Os07g0512000) Os07t0694600-01(Os07g0694600) Os09t0565700-01(Os09g0565700) Os09t0566050-00(Os09g0566050) Os10t0523700-01(Os10g0523700)
ATS: 109740994(LOC109740994) 109744157(LOC109744157) 109744455(LOC109744455) 109744485(LOC109744485) 109748350(LOC109748350) 109757942(LOC109757942) 109757944(LOC109757944)
CRE: CHLREDRAFT_196330(PRD1)
MNG: MNEG_6763
APRO: F751_4323
MGR: MGG_01438
MBE: MBM_00670
PTE: PTT_20354
SPT: SPA1000
SEK: SSPA0932
SEI: SPC_1849
SBZ: A464_2147
KPN: KPN_02982
KPU: KP1_4242
KPP: A79E_1121
KPE: KPK_1149(pheC)
KPR: KPR_1308
KPJ: N559_1254
KPX: PMK1_00455(pheC)
KPNU: LI86_06220
KPNK: BN49_1140
KVA: Kvar_1086
KOX: KOX_00340
KOE: A225_4510
EAE: EAE_01295
EAR: CCG33739
PSTS: E05_43720
YPE: YPO3343
YPK: y0847
YPH: YPC_3661
YPA: YPA_2800
YPN: YPN_0750
YPM: YP_0344(artI1)
YPZ: YPZ3_2943
YPD: YPD4_2930
YPX: YPD8_2928
YPW: CH59_2706
YPJ: CH55_1922
YPV: BZ15_180
YPL: CH46_1752
YPS: YPTB0789
YPO: BZ17_1767
YPY: YPK_3412
YPB: YPTS_0823
YPQ: DJ40_1584
YPU: BZ21_4171
YPR: BZ20_1269
YPC: BZ23_264
YPF: BZ19_137
YAL: AT01_3326
YFR: AW19_5
YKR: CH54_1657
YRO: CH64_3411
SPE: Spro_4447
SRL: SOD_c42580(pheC)
SPLY: Q5A_023205(pheC_2)
SMAF: D781_4181
SMAR: SM39_3903(pheC)
SMAC: SMDB11_3702(pheC)
SERF: L085_06140
RAA: Q7S_20755
SOD: Sant_1041(pheC)
PES: SOPEG_3261(pheC)
DDQ: DDI_3399
EPY: EpC_04440
EPR: EPYR_00467(pheC)
EAM: EAMY_0458(pheC)
EAY: EAM_2966
EBI: EbC_38320
ERJ: EJP617_16080(pheC)
EGE: EM595_0552(pheC)
PAM: PANA_3365(pheC)
PLF: PANA5342_0693(pheC)
PAJ: PAJ_2610(pheC)
PVA: Pvag_2641(pheC)
PSTW: DSJ_20475
LRI: NCTC12151_00836(pheC)
MSU: MS0900(artI)
ASU: Asuc_1338
XCC: XCC3537(pheC)
XCB: XC_0623
XCP: XCR_3878
XCV: XCV0653(pheC)
XAX: XACM_0600(pheC)
XAC: XAC0598(pheC)
XCI: XCAW_03985(artI)
XAL: XALC_2973(pheC)
VVU: VV1_1025
VVY: VV3248
VPA: VP3065
VPB: VPBB_2914
VAG: N646_2165
VFI: VF_1270
PPR: PBPRA2122(VV3248)
PAE: PA3475(pheC)
PAEV: N297_3598(pheC)
PAEI: N296_3598(pheC)
PAU: PA14_19140(pheC)
PAP: PSPA7_1651(pheC)
PAG: PLES_15371(pheC)
PAF: PAM18_1490(pheC)
PNC: NCGM2_4615(pheC)
PAEB: NCGM1900_2793(pheC)
PAEP: PA1S_07940
PAEM: U769_07415
PAEL: T223_07655
PAEU: BN889_03860(pheC)
PAEG: AI22_25960
PAEC: M802_3597(pheC)
PAEO: M801_3463(pheC)
PSB: Psyr_1151
PSYR: N018_19900
PFL: PFL_1493(pheC)
PPRC: PFLCHA0_c15320(pheC)
PPRO: PPC_1546(pheC)
PFO: Pfl01_3814(pheC)
PFS: PFLU_1513(pheC)
PFC: PflA506_1529(pheC)
PFW: PF1751_v1c14970(pheC)
PFB: VO64_4651
PMAN: OU5_5582
PSTT: CH92_14880
PPUU: PputUW4_03490(pheC)
PSES: PSCI_0626
PSEM: TO66_07360
PSOS: POS17_1504(pheC)
PANR: A7J50_1636
PSIL: PMA3_08810
SBL: Sbal_3744
SPSW: Sps_01948
FTQ: RO31_0314
FTW: FTW_1809(pheC)
FTL: FTL_0187
FTH: FTH_0181
FTA: FTA_0202
FTS: F92_01045
FTI: FTS_0183
FTC: DA46_532
FTV: CH67_462
FTZ: CH68_197
FTM: FTM_1575
FTN: FTN_0191
FTX: AW25_9
FTD: AS84_522
FTY: CH70_1899
FPH: Fphi_0635
FPT: BZ13_1391
FPI: BF30_837
FPM: LA56_1538
FPX: KU46_717
FPZ: LA55_165
FPJ: LA02_249
FNA: OOM_0170
GAI: IMCC3135_21515(pheC)
CVI: CV_0224
RSO: RSc2512
RSC: RCFBP_10886(pheC)
RSL: RPSI07_0954(pheC)
RSN: RSPO_c00942(pheC)
RSM: CMR15_10865(pheC)
RSE: F504_2454
RPI: Rpic_2779
RIN: ACS15_2802(pheC)
CNC: CNE_1c17390(pheC)
BMA: BMA2961(pheC)
BMV: BMASAVP1_A3350(pheC)
BML: BMA10229_A1581(pheC)
BMN: BMA10247_3021(pheC)
BMAL: DM55_995(pheC)
BMAE: DM78_90(pheC)
BMAQ: DM76_970(pheC)
BMAI: DM57_1694
BMAF: DM51_2572
BMAZ: BM44_329(pheC)
BMAB: BM45_2943
BPS: BPSL3392(pheC)
BPM: BURPS1710b_0172(pheC)
BPL: BURPS1106A_4037(pheC)
BPD: BURPS668_3964(pheC)
BPSE: BDL_1986(pheC)
BPSM: BBQ_3445(pheC)
BPSU: BBN_30(pheC)
BPSD: BBX_377(pheC)
BPZ: BP1026B_I3681(pheC)
BPK: BBK_1471(pheC)
BPSH: DR55_1113(pheC)
BPSA: BBU_2143(pheC)
BPSO: X996_718(pheC)
BUT: X994_2708
BTE: BTH_I3305
BTQ: BTQ_3241(pheC)
BTJ: BTJ_2465(pheC)
BTZ: BTL_408(pheC)
BTD: BTI_167(pheC)
BTV: BTHA_376(pheC)
BTHE: BTN_985(pheC)
BTHM: BTRA_582(pheC)
BTHA: DR62_1149
BTHL: BG87_582
BOK: DM82_3117
BOC: BG90_1618
BVE: AK36_649
BCN: Bcen_2945
BCJ: BCAL0039(pheC)
BCEN: DM39_3380
BCEW: DM40_886
BCEO: I35_0041(pheC)
BAM: Bamb_0100
BMU: Bmul_0111
BMJ: BMULJ_03155(pheA)
BMK: DM80_1582
BMUL: NP80_238
BCT: GEM_0105
BCED: DM42_1672
BDL: AK34_2978
BCON: NL30_18970
BUB: BW23_1601
BLAT: WK25_02150
BTEI: WS51_11370
BSEM: WJ12_00575
BPSL: WS57_13525
BMEC: WJ16_00545
BSTG: WT74_00685
BGU: KS03_991
BGO: BM43_1489
BUK: MYA_0107
BUL: BW21_240
BGP: BGL_1c00750(pheC)
BXE: Bxe_A0043
BXB: DR64_2222
BPH: Bphy_3024
BFN: OI25_1550
PPNO: DA70_17070
PPNM: LV28_13680
PPUL: RO07_07615
PSPU: NA29_03495
PAPI: SG18_08055
PLG: NCTC10937_01337(pheC)
PUT: PT7_0948
AMIM: MIM_c06300
AAV: Aave_2470
AAA: Acav_2744
VPD: VAPA_1c49230(pheC)
HSE: Hsero_4358(pheC)
HRB: Hrubri_4286(pheC)
CFU: CFU_4385
CARE: LT85_4942
CPRA: CPter91_5456(pheC)
PLA: Plav_0286
SFD: USDA257_c22150(pheC)
SAME: SAMCFNEI73_pC1050(pheC)
ARA: Arad_7421
AVI: Avi_0614
BJA: blr4561(pheC)
BRA: BRADO3810
BBT: BBta_4123
BRS: S23_35510(pheC)
AOL: S58_38530
BRAD: BF49_6932
BRO: BRAD285_3567(pheC)
AZC: AZC_2410
MET: M446_2737
MNO: Mnod_4388
MAQU: Maq22A_c16670(hisJ) Maq22A_c26755(hisJ)
PSF: PSE_1115
OTM: OSB_26110(pheC)
PUB: SAR11_1068(pheC)
BACO: OXB_2668
ESI: Exig_1225
EAN: Eab7_1174
CACE: CACET_c30780(pheC)
SRI: SELR_07540(pheC)
MHAD: B586_04145
MSTE: MSTE_03781(pheC)
SCT: SCAT_4965(pheC)
SBH: SBI_02924
SALU: DC74_6424
SALL: SAZ_32270
STRE: GZL_02586
SLD: T261_1820
SNR: SNOUR_11030(pheC)
SMAL: SMALA_6043
SALF: SMD44_08395(pheC)
SFK: KY5_0958c
AAI: AARI_31560(pheC)
LMOI: VV02_07970
SERJ: SGUI_2974
NAL: B005_0259(pheC)
SEN: SACE_1605(pheC)
AOI: AORI_7330
AJA: AJAP_02335(pheC)
PSEA: WY02_02700
PSEE: FRP1_12395
PSEH: XF36_10260
KAL: KALB_4708
FVA: FV113G1_16900(pheC)
PRU: PRU_0284(pheC)
SAI: Saci_0712
 » show all
Taxonomy
Reference
1  [PMID:3600377]
  Authors
Fischer R, Jensen R.
  Title
Arogenate dehydratase.
  Journal
Methods Enzymol 142:495-502 (1987)
Reference
2  [PMID:2972718]
  Authors
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA.
  Title
Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa.
  Journal
J Biol Chem 263:17284-90 (1988)
Reference
3  [PMID:3124763]
  Authors
Siehl DL, Conn EE.
  Title
Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) Moench.
  Journal
Arch Biochem Biophys 260:822-9 (1988)
DOI:10.1016/0003-9861(88)90513-9
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.91
IUBMB Enzyme Nomenclature: 4.2.1.91
ExPASy - ENZYME nomenclature database: 4.2.1.91
BRENDA, the Enzyme Database: 4.2.1.91
CAS: 76600-70-9

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