KEGG   ENZYME: 4.2.1.94Help
Entry
EC 4.2.1.94                 Enzyme                                 

Name
scytalone dehydratase;
scytalone 7,8-hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)
Reaction(IUBMB)
scytalone = 1,3,8-trihydroxynaphthalene + H2O [RN:R02907]
Reaction(KEGG)
Substrate
scytalone [CPD:C00779]
Product
1,3,8-trihydroxynaphthalene [CPD:C01173];
H2O [CPD:C00001]
Comment
Involved, with EC 1.1.1.252 tetrahydroxynaphthalene reductase, in the biosynthesis of melanin in pathogenic fungi.
History
EC 4.2.1.94 created 1992
Orthology
K17740  scytalone dehydratase
Genes
NCR: NCU07823
NTE: NEUTE1DRAFT116788(NEUTE1DRAFT_116788)
SMP: SMAC_02101(sdh)
PAN: PODANSg5567
TTT: THITE_2120303
MTM: MYCTH_102118 MYCTH_2294550 MYCTH_2305635
CTHR: CTHT_0071160
MGR: MGG_05059
TMN: UCRPA7_1777 UCRPA7_5366
SSCK: SPSK_06530
MAW: MAC_08229
ANG: ANI_1_2396074(An08g09920)
 » show all
Taxonomy
Reference
1
  Authors
Butler, M.J., Lazarovits, G., Higgins, V.J. and Lachance, M.-A.
  Title
Partial-purification and characterization of a dehydratase associated with the pentaketide melanogenesis pathway of Phaeococcomyces sp and other fungi.
  Journal
Exp Mycol 12:367-376 (1988)
Reference
2
  Authors
Tajima, S., Kubo, Y., Furusawa, I. and Shishiyama, J.
  Title
Purification of a melanin biosynthetic enzyme converting scytalone to 1,3,8-trihydroxynaphthalene from Cochliobolus miyabeanus.
  Journal
Exp Mycol 13:69 (1989)
Reference
3
  Authors
Wheeler, M.H. and Greenblatt, G.A.
  Title
The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease.
  Journal
Exp Mycol 12:151-160 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.94
IUBMB Enzyme Nomenclature: 4.2.1.94
ExPASy - ENZYME nomenclature database: 4.2.1.94
BRENDA, the Enzyme Database: 4.2.1.94
CAS: 118901-79-4

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