KEGG   ENZYME: 4.2.2.3Help
Entry
EC 4.2.2.3                  Enzyme                                 

Name
mannuronate-specific alginate lyase;
alginate lyase I;
alginate lyase;
alginase I;
alginase II;
alginase;
poly(beta-D-1,4-mannuronide) lyase;
poly(beta-D-mannuronate) lyase;
aly (gene name) (ambiguous);
poly[(1->4)-beta-D-mannuronide] lyase
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
alginate beta-D-mannuronate---uronate lyase
Reaction(IUBMB)
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at their reducing end.
Reaction(KEGG)
(other) R03706
Show
Comment
The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11, guluronate-specific alginate lyase.
History
EC 4.2.2.3 created 1965 as EC 4.2.99.4, transferred 1972 to EC 4.2.2.3, modified 1990, modified 2015
Pathway
ec00051  Fructose and mannose metabolism
Orthology
K01729  poly(beta-D-mannuronate) lyase
Genes
ENT: Ent638_2038
EAS: Entas_2195
ENR: H650_02880
ENF: AKI40_3131(algL)
KSA: C813_03495
KOR: AWR26_12900
KRD: A3780_11145
KCO: BWI95_16205
LAX: APT61_11230
LEH: C3F35_00390
SMT: Smal_2066
SMZ: SMD_1308
PSUW: WQ53_03475
PAE: PA3547(algL)
PAEV: N297_3670(algL)
PAEI: N296_3670(algL)
PAU: PA14_18470(algL)
PAP: PSPA7_1598(algL)
PAG: PLES_14861(algL)
PAF: PAM18_1439(algL)
PNC: NCGM2_4672(algL)
PAEB: NCGM1900_2737(algL)
PDK: PADK2_06630(algL)
PSG: G655_07065(algL)
PRP: M062_18790(algL)
PAEP: PA1S_07685(algL)
PAEM: U769_07160(algL)
PAEL: T223_07400(algL)
PAEU: BN889_03918(algL)
PAEG: AI22_26220(algL)
PAEC: M802_3667(algL)
PAEO: M801_3535(algL)
PMK: MDS_1075
PRE: PCA10_11810(algL) PCA10_38160(algL)
PCQ: PcP3B5_50750(algL)
PPU: PP_1281(algL)
PPF: Pput_4444
PPT: PPS_4410
PPB: PPUBIRD1_4280(algL)
PPI: YSA_03107
PPX: T1E_3160(algL)
PPUH: B479_22185(algL)
PPUT: L483_27270(algL)
PPUN: PP4_07930(algL)
PPUD: DW66_4801
PMON: X969_21720(algL)
PMOT: X970_21355(algL)
PST: PSPTO_1236(algL)
PSB: Psyr_1056(algL)
PSYR: N018_20390(algL)
PSP: PSPPH_1111(algL)
PFL: PFL_1017(algL)
PPRC: PFLCHA0_c10370(algL)
PPRO: PPC_1055(algL)
PFO: Pfl01_0953(algL)
PFS: PFLU_0983(algL)
PFC: PflA506_0963(algL)
PFN: HZ99_11950(algL)
PFW: PF1751_v1c09410(algL)
PFF: PFLUOLIPICF703425(algL)
PFX: A7318_04255(algL)
PPZ: H045_01655(algL)
PFB: VO64_4064
PMAN: OU5_2454(algL)
PTV: AA957_09080(algL)
PCG: AXG94_10010(algL)
PVR: PverR02_05190(algL)
PAZO: AYR47_12195(algL)
POI: BOP93_04700(algL)
PEN: PSEEN3462 PSEEN4542(algL)
PBC: CD58_24340(algL)
PPUU: PputUW4_04478(algL)
PDR: H681_19460(algL)
PSV: PVLB_04200(algL1) PVLB_15515(algL2)
PSK: U771_06090(algL)
PKC: PKB_0961(algL)
PCH: EY04_04485(algL)
PCP: JM49_25160(algL)
PFZ: AV641_18545(algL)
PLQ: AA042_15115(algL)
PPV: NJ69_13865(algL)
PSES: PSCI_0728(algL)
PSEM: TO66_05175(algL)
PPSY: AOC04_15765(algL)
PSOS: POS17_1023(algL)
PKR: AYO71_07505(algL)
PFK: PFAS1_06365(algL)
PANR: A7J50_0985
PSIL: PMA3_24620(algL)
AVN: Avin_10900(algL)
AVL: AvCA_10900(algL)
AVD: AvCA6_10900(algL)
ACX: Achr_31250(algL)
SFR: Sfri_3103
PEA: PESP_a2550(algL)
PART: PARC_a2610(algL)
AMAL: I607_15845
AMAE: I876_16140
AMAO: I634_16085
AMAG: I533_15670
AMAC: MASE_04135
AAUS: EP12_16280
SDE: Sde_2478(alg7C) Sde_2547(alg7B) Sde_2839(ply7E) Sde_2873(alg6A) Sde_3274(ply6D) Sde_3275(ply6C) Sde_3285(ply6E) Sde_3286(ply7F)
SAGA: M5M_10450
ABO: ABO_0393(algL)
TAU: Tola_1413
RPI: Rpic_3571
BCEW: DM40_5784
BCON: NL30_32690
BLAT: WK25_19105
BTEI: WS51_28830
BSEM: WJ12_19980
PSPU: NA29_15685
PAPI: SG18_20430
PLG: NCTC10937_04290(algL)
BAV: BAV2839
CARE: LT85_0132
MNO: Mnod_5878
MMED: Mame_02312(algL)
MALG: MALG_02784
HBA: Hbal_2772
SPHP: LH20_00375
SPHU: SPPYR_0942
ADO: A6F68_01720(cslB)
SVE: SVEN_0074
AOI: AORI_3483(algL)
KAL: KALB_5431
RBA: RB3601
FMR: Fuma_04814(cslB)
BCEL: BcellWH2_01214(cslB)
MBAS: ALGA_3306
RMR: Rmar_1165
FLM: MY04_2548
GFO: GFO_1147
DDO: I597_0905(cslB)
ZGA: ZOBELLIA_4130(alyA4) ZOBELLIA_4132(alyA6)
TJE: TJEJU_2495(alyA4)
 » show all
Taxonomy
Reference
1  [PMID:13144]
  Authors
Davidson IW, Lawson CJ, Sutherland IW.
  Title
An alginate lysate from Azotobacter vinelandii phage.
  Journal
J Gen Microbiol 98:223-9 (1977)
DOI:10.1099/00221287-98-1-223
Reference
2  [PMID:6020438]
  Authors
Nakada HI, Sweeny PC.
  Title
Alginic acid degradation by eliminases from abalone hepatopancreas.
  Journal
J Biol Chem 242:845-51 (1967)
Reference
3  [PMID:14488584]
  Authors
PREISS J, ASHWELL G.
  Title
Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosac-charides and 4-deoxy-L-erythro-5-hexoseulose uronic acid.
  Journal
J Biol Chem 237:309-16 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.3
IUBMB Enzyme Nomenclature: 4.2.2.3
ExPASy - ENZYME nomenclature database: 4.2.2.3
BRENDA, the Enzyme Database: 4.2.2.3
CAS: 9024-15-1

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