KEGG   ENZYME: 4.2.2.7Help
Entry
EC 4.2.2.7                  Enzyme                                 

Name
heparin lyase;
heparin eliminase;
heparinase
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
heparin lyase
Reaction(IUBMB)
Eliminative cleavage of polysaccharides containing (1->4)-linked D-glucuronate or L-iduronate residues and (1->4)-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends
History
EC 4.2.2.7 created 1972
Orthology
K19050  heparin lyase
K19051  heparin/heparan-sulfate lyase
Genes
BTH: BT_4675
BHL: Bache_1608
BXY: BXY_37770
ASH: AL1_01250
NKO: Niako_3778
PHE: Phep_0472 Phep_2408
PSN: Pedsa_0684
COC: Coch_0606
Taxonomy
Reference
1  [PMID:5484472]
  Authors
Hovingh P, Linker A.
  Title
The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria.
  Journal
J Biol Chem 245:6170-5 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.7
IUBMB Enzyme Nomenclature: 4.2.2.7
ExPASy - ENZYME nomenclature database: 4.2.2.7
BRENDA, the Enzyme Database: 4.2.2.7
CAS: 9025-39-2

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