KEGG   ENZYME: 4.2.3.10Help
Entry
EC 4.2.3.10                 Enzyme                                 

Name
(-)-endo-fenchol synthase;
(-)-endo-fenchol cyclase;
geranyl pyrophosphate:(-)-endo-fenchol cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (-)-endo-fenchol + diphosphate [RN:R02004]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(-)-endo-fenchol [CPD:C02344];
diphosphate [CPD:C00013]
Comment
(3R)-Linalyl diphosphate is an intermediate in the reaction
History
EC 4.2.3.10 created 1992 as EC 4.6.1.8, transferred 2000 to EC 4.2.3.10
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15097  (-)-endo-fenchol synthase
Reference
1  [PMID:2919880]
  Authors
Croteau R, Miyazaki JH, Wheeler CJ.
  Title
Monoterpene biosynthesis: mechanistic evaluation of the geranyl pyrophosphate:(-)-endo-fenchol cyclase from fennel (Foeniculum vulgare).
  Journal
Arch Biochem Biophys 269:507-16 (1989)
DOI:10.1016/0003-9861(89)90134-3
Reference
2  [PMID:3170591]
  Authors
Croteau R, Satterwhite DM, Wheeler CJ, Felton NM.
  Title
Biosynthesis of monoterpenes. Stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (-)-endo-fenchol.
  Journal
J Biol Chem 263:15449-53 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.10
IUBMB Enzyme Nomenclature: 4.2.3.10
ExPASy - ENZYME nomenclature database: 4.2.3.10
BRENDA, the Enzyme Database: 4.2.3.10
CAS: 117758-41-5

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