KEGG   ENZYME: 4.2.3.104Help
Entry
EC 4.2.3.104                Enzyme                                 

Name
alpha-humulene synthase;
ZSS1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-humulene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate [RN:R08373]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
alpha-humulene [CPD:C09684];
diphosphate [CPD:C00013]
Comment
The enzyme from Zingiber zerumbet, shampoo ginger, also gives traces of beta-caryophyllene.
History
EC 4.2.3.104 created 2012
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14184  alpha-humulene/beta-caryophyllene synthase
Genes
ATH: AT5G23960(TPS21)
ALY: ARALYDRAFT_348000
CRB: 17882696 17886620
CSAT: 104706692
EUS: EUTSA_v10012105mg EUTSA_v10012129mg
BRP: 103849526 103849591 103874257
BNA: 106352011 106380498
BOE: 106301560 106326551
THJ: 104818160 104818164 104818498
EGU: 105034997
MUS: 103992270
 » show all
Taxonomy
Reference
1  [PMID:18273640]
  Authors
Yu F, Okamto S, Nakasone K, Adachi K, Matsuda S, Harada H, Misawa N, Utsumi R
  Title
Molecular cloning and functional characterization of alpha-humulene synthase, a possible key enzyme of zerumbone biosynthesis in shampoo ginger (Zingiber zerumbet Smith).
  Journal
Planta 227:1291-9 (2008)
DOI:10.1007/s00425-008-0700-x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.104
IUBMB Enzyme Nomenclature: 4.2.3.104
ExPASy - ENZYME nomenclature database: 4.2.3.104
BRENDA, the Enzyme Database: 4.2.3.104

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