KEGG   ENZYME: 4.2.3.110Help
Entry
EC 4.2.3.110                Enzyme                                 

Name
(+)-sabinene synthase;
SS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-sabinene-forming]
Reaction(IUBMB)
geranyl diphosphate = (+)-sabinene + diphosphate [RN:R09966]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341]
Product
(+)-sabinene [CPD:C20230];
diphosphate [CPD:C00013]
Comment
Isolated from Salvia officinalis (sage). The recombinant enzyme gave 63% (+)-sabinene, 21% gamma-terpinene, and traces of other monoterpenoids. See EC 4.2.3.114 gamma-terpinene synthase.
History
EC 4.2.3.110 created 2012
Orthology
K21939  (+)-sabinene/gamma-terpinene synthase
Reference
1  [PMID:9614092]
  Authors
Wise ML, Savage TJ, Katahira E, Croteau R.
  Title
Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase.
  Journal
J Biol Chem 273:14891-9 (1998)
DOI:10.1074/jbc.273.24.14891
  Sequence
Reference
2  [PMID:12941302]
  Authors
Peters RJ, Croteau RB
  Title
Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases.
  Journal
Arch Biochem Biophys 417:203-11 (2003)
DOI:10.1016/S0003-9861(03)00347-3
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.110
IUBMB Enzyme Nomenclature: 4.2.3.110
ExPASy - ENZYME nomenclature database: 4.2.3.110
BRENDA, the Enzyme Database: 4.2.3.110

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