KEGG   ENZYME: 4.2.3.113Help
Entry
EC 4.2.3.113                Enzyme                                 

Name
terpinolene synthase;
ag9;
PmeTPS2;
LaLIMS_RR
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase (cyclizing, terpinolene-forming)
Reaction(IUBMB)
geranyl diphosphate = terpinolene + diphosphate [RN:R02010]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341]
Product
terpinolene [CPD:C06075];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. Mn2+ is less effective and product ratio changes. Forms traces of other monoterpenoids.
History
EC 4.2.3.113 created 2012
Orthology
K21930  terpinolene synthase
Reference
1  [PMID:2768265]
  Authors
Croteau R, Satterwhite DM
  Title
Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage.
  Journal
J Biol Chem 264:15309-15 (1989)
Reference
2  [PMID:10441373]
  Authors
Bohlmann J, Phillips M, Ramachandiran V, Katoh S, Croteau R
  Title
cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis).
  Journal
Arch Biochem Biophys 368:232-43 (1999)
DOI:10.1006/abbi.1999.1332
  Sequence
Reference
3  [PMID:12602896]
  Authors
Faldt J, Martin D, Miller B, Rawat S, Bohlmann J
  Title
Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced  terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase.
  Journal
Plant Mol Biol 51:119-33 (2003)
Reference
4  [PMID:15921711]
  Authors
Huber DP, Philippe RN, Godard KA, Sturrock RN, Bohlmann J
  Title
Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii.
  Journal
Phytochemistry 66:1427-39 (2005)
DOI:10.1016/j.phytochem.2005.04.030
Reference
5  [PMID:17662687]
  Authors
Landmann C, Fink B, Festner M, Dregus M, Engel KH, Schwab W
  Title
Cloning and functional characterization of three terpene synthases from lavender  (Lavandula angustifolia).
  Journal
Arch Biochem Biophys 465:417-29 (2007)
DOI:10.1016/j.abb.2007.06.011
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.113
IUBMB Enzyme Nomenclature: 4.2.3.113
ExPASy - ENZYME nomenclature database: 4.2.3.113
BRENDA, the Enzyme Database: 4.2.3.113

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