KEGG   ENZYME: 4.2.3.118Help
Entry
EC 4.2.3.118                Enzyme                                 

Name
2-methylisoborneol synthase;
sco7700;
2-MIB cyclase;
MIB synthase;
MIBS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming)
Reaction(IUBMB)
(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol + diphosphate [RN:R09973]
Reaction(KEGG)
Substrate
(E)-2-methylgeranyl diphosphate [CPD:C20235];
H2O [CPD:C00001]
Product
2-methylisoborneol [CPD:C20243];
diphosphate [CPD:C00013]
Comment
The product, 2-methylisoborneol, is a characteristc odiferous compound with a musty smell produced by soil microorganisms.
History
EC 4.2.3.118 created 2012
Orthology
K16218  2-methylisoborneol synthase
Genes
PFO: Pfl01_1841
NBR: O3I_014430
NNO: NONO_c25610
NSR: NS506_05722(mibS)
NTP: CRH09_13810
SCO: SCO7700(SC1A4.08)
SGR: SGR_1269
SCB: SCAB_5041 SCAB_82161
SVL: Strvi_5648
SFA: Sfla_5667
SBH: SBI_08957
SVE: SVEN_7111
STRP: F750_0931
SALU: DC74_7952
SALL: SAZ_41055
STRM: M444_04660
SMAL: SMALA_1169
SLAU: SLA_6491
SALJ: SMD11_0058(mibs) SMD11_0841(mibs)
SFK: KY5_0684
KSK: KSE_70210
NDA: Ndas_2620
NAL: B005_4057
SEN: SACE_3722
AMD: AMED_3240
AMN: RAM_16480
AMM: AMES_3205
AMZ: B737_3205
AOI: AORI_4062
SESP: BN6_59350
KAL: KALB_4605
ALL: CRK56091
ASE: ACPL_2023
ACTS: ACWT_1901
CAI: Caci_4612
SNA: Snas_1991
 » show all
Taxonomy
Reference
1  [PMID:18563898]
  Authors
Wang CM, Cane DE
  Title
Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.
  Journal
J Am Chem Soc 130:8908-9 (2008)
DOI:10.1021/ja803639g
  Sequence
[sco:SCO7700]
Reference
2  [PMID:18492804]
  Authors
Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H
  Title
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.
  Journal
Proc Natl Acad Sci U S A 105:7422-7 (2008)
DOI:10.1073/pnas.0802312105
  Sequence
Reference
3  [PMID:21174459]
  Authors
Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT
  Title
Biosynthesis of 2-methylisoborneol in cyanobacteria.
  Journal
Environ Sci Technol 45:992-8 (2011)
DOI:10.1021/es102992p
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.118
IUBMB Enzyme Nomenclature: 4.2.3.118
ExPASy - ENZYME nomenclature database: 4.2.3.118
BRENDA, the Enzyme Database: 4.2.3.118

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