KEGG   ENZYME: 4.2.3.13Help
Entry
EC 4.2.3.13                 Enzyme                                 

Name
(+)-delta-cadinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate [RN:R02311]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-delta-cadinene [CPD:C06394];
diphosphate [CPD:C00013]
Comment
The sesquiterpenoid (+)-delta-cadinene is an intermediate in phytoalexin biosynthesis. Mg2+ is required for activity.
History
EC 4.2.3.13 created 1999 as EC 4.6.1.11, transferred 2000 to EC 4.2.3.13, modified 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14183  (+)-delta-cadinene synthase
K22065  alpha-copaene/(+)-delta-cadinene synthase
Genes
TCC: 18593708 18593709
GRA: 105768271 105768272 105768274 105768275 105768276 105768277 105781617 105784507 105786286 105786287
GHI: 107895205 107895206 107902908 107903499 107903500 107903503 107903504 107903509 107918736 107918747 107918752 107920688 107920690 107920806 107925546 107925552 107925569 107925582 107928183
DZI: 111276466
RCU: 8280754
JCU: 105633238
HAN: 110893972
Taxonomy
Reference
1  [PMID:8554317]
  Authors
Chen XY, Chen Y, Heinstein P, Davisson VJ.
  Title
Cloning, expression, and characterization of (+)-delta-cadinene synthase: a catalyst for cotton phytoalexin biosynthesis.
  Journal
Arch Biochem Biophys 324:255-66 (1995)
DOI:10.1006/abbi.1995.0038
  Sequence
Reference
2  [PMID:8728715]
  Authors
Davis EM, Tsuji J, Davis GD, Pierce ML, Essenberg M.
  Title
Purification of (+)-delta-cadinene synthase, a sesquiterpene cyclase from bacteria-inoculated cotton foliar tissue.
  Journal
Phytochemistry 41:1047-55 (1996)
DOI:10.1016/0031-9422(95)00771-7
  Sequence
Reference
3
  Authors
Davis, G.D., Essenberg, M.
  Title
(+)-delta-Cadinene is a product of sesquiterpene cyclase activity in cotton.
  Journal
Phytochemistry 39:553-567 (1995)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.13
IUBMB Enzyme Nomenclature: 4.2.3.13
ExPASy - ENZYME nomenclature database: 4.2.3.13
BRENDA, the Enzyme Database: 4.2.3.13
CAS: 166800-09-5

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