KEGG   ENZYME: 4.2.3.133Help
Entry
EC 4.2.3.133                Enzyme                                 

Name
alpha-copaene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-copaene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-copaene + diphosphate [RN:R10584]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-copaene [CPD:C09639];
diphosphate [CPD:C00013]
Comment
Isolated from Helianthus annuus (sunflower). The enzyme also produces beta-caryophyllene, delta-cadinene and traces of other sesquiterpenoids. See EC 4.2.3.13 (+)-delta-cadinene synthase, EC 4.2.3.57 (-)-beta-caryophyllene synthase.
History
EC 4.2.3.133 created 2012
Orthology
K22065  alpha-copaene/(+)-delta-cadinene synthase
Genes
RCU: 8280754
JCU: 105633238
HAN: 110893972
Taxonomy
Reference
1  [PMID:19580670]
  Authors
Gopfert JC, Macnevin G, Ro DK, Spring O
  Title
Identification, functional characterization and developmental regulation of sesquiterpene synthases from sunflower capitate glandular trichomes.
  Journal
BMC Plant Biol 9:86 (2009)
DOI:10.1186/1471-2229-9-86
  Sequence
Reference
2  [PMID:22459969]
  Authors
Xie X, Kirby J, Keasling JD
  Title
Functional characterization of four sesquiterpene synthases from Ricinus communis (castor bean).
  Journal
Phytochemistry 78:20-8 (2012)
DOI:10.1016/j.phytochem.2012.02.022
  Sequence
[rcu:8280754]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.133
IUBMB Enzyme Nomenclature: 4.2.3.133
ExPASy - ENZYME nomenclature database: 4.2.3.133
BRENDA, the Enzyme Database: 4.2.3.133

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