KEGG   ENZYME: 4.2.3.134Help
Entry
EC 4.2.3.134                Enzyme                                 

Name
5-phosphonooxy-L-lysine phospho-lyase;
5-phosphohydroxy-L-lysine ammoniophospholyase;
AGXT2L2 (gene name);
(5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating;
(S)-2-amino-6-oxohexanoate-forming)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(5R)-5-phosphooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming)
Reaction(IUBMB)
(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH3 + phosphate [RN:R10270]
Reaction(KEGG)
Substrate
(5R)-5-phosphooxy-L-lysine [CPD:C03366];
H2O [CPD:C00001]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NH3 [CPD:C00014];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein. Has no activity with phosphoethanolamine (cf. EC 4.2.3.2, ethanolamine-phosphate phospho-lyase).
History
EC 4.2.3.134 created 2012
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18202  5-phosphonooxy-L-lysine phospho-lyase
Genes
HSA: 85007(PHYKPL)
PTR: 462320(PHYKPL)
PPS: 100991193(PHYKPL)
GGO: 101136630(PHYKPL)
PON: 100442768(PHYKPL)
NLE: 100580387 100606772(PHYKPL)
MCC: 702302(PHYKPL)
MCF: 102115019(PHYKPL)
CSAB: 103245075(PHYKPL)
RRO: 104661301(PHYKPL)
RBB: 108544791(PHYKPL)
CJC: 100391170(PHYKPL)
SBQ: 101029497(PHYKPL)
MMU: 72947(Phykpl)
RNO: 100169747(Phykpl) 103690164
CGE: 100767825(Phykpl)
NGI: 103734701(Phykpl)
HGL: 101713270(Phykpl)
CCAN: 109690864(Phykpl)
OCU: 100338220(PHYKPL)
TUP: 102467962(PHYKPL)
CFA: 481448(PHYKPL)
AML: 100466352(PHYKPL)
UMR: 103679971(PHYKPL)
ORO: 101377479(PHYKPL)
FCA: 101098679(PHYKPL)
PTG: 102972570(PHYKPL)
AJU: 106969712(PHYKPL)
BTA: 537241(PHYKPL)
BOM: 102276016(PHYKPL)
BIU: 109561922(PHYKPL)
PHD: 102327522(PHYKPL)
CHX: 102191693(PHYKPL)
OAS: 101108046(PHYKPL)
SSC: 100521952(PHYKPL)
CFR: 102522088(PHYKPL)
CDK: 105099607(PHYKPL)
BACU: 103000047(PHYKPL)
LVE: 103086842(PHYKPL)
OOR: 101272238(PHYKPL)
ECB: 100068397(PHYKPL)
EPZ: 103563672(PHYKPL)
EAI: 106827133(PHYKPL)
MYB: 102249621(PHYKPL)
MYD: 102752367(PHYKPL)
HAI: 109389777(PHYKPL)
RSS: 109434238(PHYKPL)
PALE: 102886040(PHYKPL)
LAV: 100665373(PHYKPL)
TMU: 101355834
SHR: 100916686(PHYKPL)
OAA: 100088790(PHYKPL)
GGA: 416374(PHYKPL)
MGP: 100538852(AGXT2L2)
CJO: 107320110(PHYKPL)
APLA: 101797808(PHYKPL)
ACYG: 106032801(PHYKPL)
TGU: 100223371(PHYKPL) 100223697
GFR: 102042452(PHYKPL)
FAB: 101818003(PHYKPL)
PHI: 102111638(PHYKPL)
PMAJ: 107210644(PHYKPL)
CCAE: 111935568(PHYKPL) 111942248
CCW: 104689598(PHYKPL)
FPG: 101922212(PHYKPL)
FCH: 102056780(PHYKPL)
CLV: 102087033(PHYKPL)
EGZ: 104128431(PHYKPL)
AAM: 106487205(PHYKPL)
ASN: 102378538
AMJ: 102560645(PHYKPL)
PSS: 102450136(PHYKPL)
CMY: 102946291(PHYKPL)
CPIC: 101930924(PHYKPL)
ACS: 100558326(phykpl)
PVT: 110073466(PHYKPL)
PBI: 103068075
GJA: 107112613(PHYKPL)
SRX: 107743705
CCAR: 109103449
IPU: 108277665
AMEX: 103047782
TRU: 101079232(phykpl)
LCO: 104922708(phykpl)
NCC: 104954680(phykpl)
MZE: 101479762
OLA: 101162691(phykpl)
XMA: 102216628(phykpl)
PRET: 103471244(phykpl)
KMR: 108240593
CSEM: 103391016(phykpl)
LCF: 108899216(phykpl)
SDU: 111226427(phykpl)
BPEC: 110157619(phykpl)
MALB: 109973167(phykpl)
SASA: 100286425(at2l1)
OTW: 112220744
ELS: 105030326(phykpl)
SFM: 108936849(phykpl)
LCM: 102347768(PHYKPL)
CMK: 103183728(phykpl)
 » show all
Taxonomy
Reference
1  [PMID:4412716]
  Authors
Tsai CH, Henderson LM
  Title
Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase.
  Journal
J Biol Chem 249:5784-9 (1974)
Reference
2  [PMID:22241472]
  Authors
Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E
  Title
Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.
  Journal
J Biol Chem 287:7246-55 (2012)
DOI:10.1074/jbc.M111.323485
  Sequence
[hsa:85007]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.134
IUBMB Enzyme Nomenclature: 4.2.3.134
ExPASy - ENZYME nomenclature database: 4.2.3.134
BRENDA, the Enzyme Database: 4.2.3.134

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