KEGG   ENZYME: 4.2.3.135Help
Entry
EC 4.2.3.135                Enzyme                                 

Name
Delta6-protoilludene synthase;
6-protoilludene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, Delta6-protoilludene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = Delta6-protoilludene + diphosphate [RN:R10271]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
Delta6-protoilludene [CPD:C20476];
diphosphate [CPD:C00013]
Comment
Isolated from the fungus Armillaria gallica. Delta6-Protoilludene is the first step in the biosynthesis of the melleolides.
History
EC 4.2.3.135 created 2012
Orthology
K22062  Delta6-protoilludene synthase
Genes
PSCO: LY89DRAFT_757172
PPL: POSPLDRAFT_101549
TVS: TRAVEDRAFT_122204
DSQ: DICSQDRAFT_57723 DICSQDRAFT_58025
SHS: STEHIDRAFT_73029
HIR: HETIRDRAFT_148791(tcc1) HETIRDRAFT_446121
PSQ: PUNSTDRAFT_108886 PUNSTDRAFT_62271
ADL: AURDEDRAFT_61813
FME: FOMMEDRAFT_112446 FOMMEDRAFT_170128
GTR: GLOTRDRAFT_64172
SLA: SERLADRAFT_441878(cyc6)
 » show all
Taxonomy
Reference
1  [PMID:21148562]
  Authors
Engels B, Heinig U, Grothe T, Stadler M, Jennewein S
  Title
Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides.
  Journal
J Biol Chem 286:6871-8 (2011)
DOI:10.1074/jbc.M110.165845
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.135
IUBMB Enzyme Nomenclature: 4.2.3.135
ExPASy - ENZYME nomenclature database: 4.2.3.135
BRENDA, the Enzyme Database: 4.2.3.135

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