KEGG   ENZYME: 4.2.3.140Help
Entry
EC 4.2.3.140                Enzyme                                 

Name
cis-abienol synthase;
Z-abienol synthase;
CAS;
ABS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol forming)
Reaction(IUBMB)
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate [RN:R10276]
Reaction(KEGG)
Substrate
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C20270]
Product
cis-abienol [CPD:C20481];
diphosphate [CPD:C00013]
Comment
Isolated from the plants Abies balsamea (balsam fir) [1] and Nicotiana tabacum (tobacco) [2].
History
EC 4.2.3.140 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20517  cis-abienol synthase
K20518  copal-8-ol diphosphate hydratase / cis-abienol synthase
Genes
NTA: 107816701(NtABS)
Taxonomy
Reference
1  [PMID:22337889]
  Authors
Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J
  Title
Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production.
  Journal
J Biol Chem 287:12121-31 (2012)
DOI:10.1074/jbc.M111.317669
  Sequence
Reference
2  [PMID:22672125]
  Authors
Sallaud C, Giacalone C, Topfer R, Goepfert S, Bakaher N, Rosti S, Tissier A
  Title
Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes.
  Journal
Plant J 72:1-17 (2012)
DOI:10.1111/j.1365-313X.2012.05068.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.140
IUBMB Enzyme Nomenclature: 4.2.3.140
ExPASy - ENZYME nomenclature database: 4.2.3.140
BRENDA, the Enzyme Database: 4.2.3.140

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (5)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (3)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (2)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
All databases (21)   

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