KEGG   ENZYME: 4.2.3.15Help
Entry
EC 4.2.3.15                 Enzyme                                 

Name
myrcene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
geranyl-diphosphate diphosphate-lyase (myrcene-forming)
Reaction(IUBMB)
geranyl diphosphate = myrcene + diphosphate [RN:R02009]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341]
Product
myrcene [CPD:C06074];
diphosphate [CPD:C00013]
Comment
A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.
History
EC 4.2.3.15 created 2000 as EC 4.1.99.9, transferred 2000 to EC 4.2.3.15
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12467  myrcene/ocimene synthase
K21925  (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
Genes
ATH: AT2G24210(TPS10) AT3G25810
ALY: ARALYDRAFT_667687
CRB: 17889158 17889311
CSAT: 104702938
BRP: 103858386 103858582
BNA: 106385578 106402047 106443840
BOE: 106328108 106334082
SLY: 101245212(TPS3)
SPEN: 107012939
SOT: 102591915
Taxonomy
Reference
1  [PMID:9268308]
  Authors
Bohlmann J, Steele CL, Croteau R.
  Title
Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.
  Journal
J Biol Chem 272:21784-92 (1997)
DOI:10.1074/jbc.272.35.21784
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.15
IUBMB Enzyme Nomenclature: 4.2.3.15
ExPASy - ENZYME nomenclature database: 4.2.3.15
BRENDA, the Enzyme Database: 4.2.3.15
CAS: 197462-59-2

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