KEGG   ENZYME: 4.2.3.19Help
Entry
EC 4.2.3.19                 Enzyme                                 

Name
ent-kaurene synthase;
ent-kaurene synthase B;
ent-kaurene synthetase B, ent-copalyl-diphosphate diphosphate-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)
Reaction(IUBMB)
ent-copalyl diphosphate = ent-kaurene + diphosphate [RN:R05092]
Reaction(KEGG)
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-kaurene [CPD:C06090];
diphosphate [CPD:C00013]
Comment
Part of a bifunctional enzyme involved in the biosynthesis of ent-kaurene. See also EC 5.5.1.13 (ent-copalyl diphosphate synthase)
History
EC 4.2.3.19 created 2002
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04121  ent-kaurene synthase
K20657  ent-copalyl diphosphate/ent-kaurene synthase
Genes
ATH: AT1G79460(GA2)
ALY: ARALYDRAFT_477113
CRB: 17894494
CSAT: 104703299 104714239 104714240 104752382
EUS: EUTSA_v10018144mg
BRP: 103832422
BNA: 106354788 106430723
BOE: 106297063
THJ: 104812382
CPAP: 110817263
CIT: 102609462
TCC: 18594964
GRA: 105782971
DZI: 111287930
EGR: 104450546
GMX: 100793849(GMDW1)
VRA: 106760976
VAR: 108332359
CCAJ: 109816872
CAM: 101506236
LJA: Lj0g3v0250739.1(Lj0g3v0250739.1) Lj0g3v0250739.2(Lj0g3v0250739.2) Lj3g3v0948400.1(Lj3g3v0948400.1) Lj3g3v0948400.2(Lj3g3v0948400.2) Lj3g3v0948400.4(Lj3g3v0948400.4)
ADU: 107458750
AIP: 107613546
LANG: 109356576
PPER: 18778990
ZJU: 107424646
CSV: 101217426(CsKS1)
CMO: 103489622
MCHA: 111016726
CMAX: 111468079
CMOS: 111455458
CPEP: 111811232
VVI: 100267397
CANN: 107878924
INI: 109156386
BVG: 104904107
NNU: 104599747
DOSA: Os02t0568700-00(Os02g0568700) Os04t0611700-00(Os04g0611700) Os04t0611800-00(Os04g0611800) Os04t0612000-00(Os04g0612000) Os11t0474800-01(Os11g0474800)
ATS: 109754648(LOC109754648) 109764882(LOC109764882) 109769786(LOC109769786) 109773968(LOC109773968) 109773969(LOC109773969) 109780574(LOC109780574) 109780577(LOC109780577) 109780593(LOC109780593)
DCT: 110092854
MGR: MGG_01949
 » show all
Taxonomy
Reference
1  [PMID:4331199]
  Authors
Fall RR, West CA.
  Title
Purification and properties of kaurene synthetase from Fusarium moniliforme.
  Journal
J Biol Chem 246:6913-28 (1971)
Reference
2  [PMID:8771778]
  Authors
Yamaguchi S, Saito T, Abe H, Yamane H, Murofushi N, Kamiya Y.
  Title
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.).
  Journal
Plant J 10:203-13 (1996)
DOI:10.1046/j.1365-313X.1996.10020203.x
Reference
3  [PMID:9268298]
  Authors
Kawaide H, Imai R, Sassa T, Kamiya Y.
  Title
Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis.
  Journal
J Biol Chem 272:21706-12 (1997)
DOI:10.1074/jbc.272.35.21706
  Sequence
Reference
4  [PMID:10803977]
  Authors
Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T.
  Title
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.
  Journal
Biosci Biotechnol Biochem 64:660-4 (2000)
DOI:10.1271/bbb.64.660
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.19
IUBMB Enzyme Nomenclature: 4.2.3.19
ExPASy - ENZYME nomenclature database: 4.2.3.19
BRENDA, the Enzyme Database: 4.2.3.19
CAS: 9055-64-5

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