KEGG   ENZYME: 4.2.3.29Help
Entry
EC 4.2.3.29                 Enzyme                                 

Name
ent-sandaracopimaradiene synthase;
OsKS10;
ent-sandaracopimara-8(14),15-diene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming]
Reaction(IUBMB)
ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate [RN:R09120]
Reaction(KEGG)
Substrate
ent-copalyl diphosphate [CPD:C06089]
Product
ent-sandaracopimara-8(14),15-diene [CPD:C11877];
diphosphate [CPD:C00013]
Comment
ent-Sandaracopimaradiene is a precursor of the rice oryzalexins A-F. Phytoalexins are diterpenoid secondary metabolites that are involved in the defense mechanism of the plant, and are produced in response to pathogen attack through the perception of elicitor signal molecules such as chitin oligosaccharide, or after exposure to UV irradiation. As a minor product, this enzyme also forms ent-pimara-8(14),15-diene, which is the sole product of EC 4.2.3.30, ent-pimara-8(14),15-diene synthase. ent-Pimara-8(14),15-diene is not a precursor in the biosynthesis of either gibberellins or phytoalexins [2].
History
EC 4.2.3.29 created 2008
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14037  ent-sandaracopimaradiene/labdatriene synthase
Genes
OSA: 4352248
DOSA: Os12t0491800-01(Os12g0491800)
Taxonomy
Reference
1  [PMID:15388982]
  Authors
Otomo K, Kanno Y, Motegi A, Kenmoku H, Yamane H, Mitsuhashi W, Oikawa H, Toshima H, Itoh H, Matsuoka M, Sassa T, Toyomasu T.
  Title
Diterpene cyclases responsible for the biosynthesis of phytoalexins, momilactones A, B, and oryzalexins A-F in rice.
  Journal
Biosci Biotechnol Biochem 68:2001-6 (2004)
DOI:10.1271/bbb.68.2001
  Sequence
[osa:4352248]
Reference
2  [PMID:16861806]
  Authors
Kanno Y, Otomo K, Kenmoku H, Mitsuhashi W, Yamane H, Oikawa H, Toshima H, Matsuoka M, Sassa T, Toyomasu T.
  Title
Characterization of a rice gene family encoding type-A diterpene cyclases.
  Journal
Biosci Biotechnol Biochem 70:1702-10 (2006)
DOI:10.1271/bbb.60044
  Sequence
[osa:4352248]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.29
IUBMB Enzyme Nomenclature: 4.2.3.29
ExPASy - ENZYME nomenclature database: 4.2.3.29
BRENDA, the Enzyme Database: 4.2.3.29

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