KEGG   ENZYME: 4.2.3.37Help
Entry
EC 4.2.3.37                 Enzyme                                 

Name
epi-isozizaene synthase;
SCO5222 protein
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate [RN:R07830]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-epi-isozizaene [CPD:C16269];
diphosphate [CPD:C00013]
Comment
Requires Mg2+ for activity. The displacement of the diphosphate group of farnesyl diphosphate occurs with retention of configuration [1]. In the soil-dwelling bacterium Streptomyces coelicolor A3(2), the product of this reaction is used by EC 1.14.13.106, epi-isozizaene 5-monooxygenase, to produce the sesquiterpene antibiotic albaflavenone [2].
History
EC 4.2.3.37 created 2008
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K10156  epi-isozizaene synthase
Genes
SCO: SCO5222(SC7E4.19)
SALB: XNR_1580
SMA: SAVERM_3032(ezs)
SHY: SHJG_6335
SHO: SHJGH_6096
SDV: BN159_3155(cyc1)
SALS: SLNWT_2072
SCI: B446_24610
SLV: SLIV_12255(cyc1)
SGU: SGLAU_22460
SAMB: SAM23877_5010(cyc)
SRW: TUE45_05742(cyc1)
SLE: sle_25180(sle_25180)
STRD: NI25_13055
 » show all
Taxonomy
Reference
1  [PMID:16669656]
  Authors
Lin X, Hopson R, Cane DE.
  Title
Genome mining in streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase.
  Journal
J Am Chem Soc 128:6022-3 (2006)
DOI:10.1021/ja061292s
  Sequence
[sco:SCO5222]
Reference
2  [PMID:18234666]
  Authors
Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE
  Title
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).
  Journal
J Biol Chem 283:8183-9 (2008)
DOI:10.1074/jbc.M710421200
  Sequence
[sco:SCO5222]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.37
IUBMB Enzyme Nomenclature: 4.2.3.37
ExPASy - ENZYME nomenclature database: 4.2.3.37
BRENDA, the Enzyme Database: 4.2.3.37

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