KEGG   ENZYME: 4.2.3.48Help
Entry
EC 4.2.3.48                 Enzyme                                 

Name
(3S,6E)-nerolidol synthase;
(E)-nerolidol synthase;
nerolidol synthase;
(3S)-(E)-nerolidol synthase;
FaNES1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate [RN:R08374]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]
Product
(3S,6E)-nerolidol [CPD:C09704];
diphosphate [CPD:C00013]
Comment
The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.
History
EC 4.2.3.48 created 2010
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14175  (3S,6E)-nerolidol synthase
Genes
THJ: 104809526
CIT: 102617431 102617651 102617908 102620886
CIC: CICLE_v10004558mg CICLE_v10014632mg CICLE_v10014707mg
TCC: 108662607 18597023 18597024
GRA: 105777993
GHI: 107924963 107940942
DZI: 111281010 111318783
EGR: 104445481 104447370 104447372 104447373 104447374 104447375 104447392 104447394 104447396 104447399 108957334
GMX: 100783015(GMTPS5) 100814957(GMTPS6)
PVU: PHAVU_002G219100g PHAVU_002G219300g PHAVU_006G195600g PHAVU_006G195700g
LJA: Lj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2) Lj0g3v0198989.3(Lj0g3v0198989.3) Lj0g3v0306569.1(Lj0g3v0306569.1) Lj6g3v2135290.1(Lj6g3v2135290.1)
LANG: 109334775
PPER: 18778181
CSV: 101215070
RCU: 8259987
SPEN: 107019618
CANN: 107845646
NTA: 107828192
NTO: 104117466
SITA: 101782336
AOF: 109820753
 » show all
Taxonomy
Reference
1  [PMID:15522848]
  Authors
Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ
  Title
Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species.
  Journal
Plant Cell 16:3110-31 (2004)
DOI:10.1105/tpc.104.023895
Reference
2  [PMID:10482672]
  Authors
Bouwmeester HJ, Verstappen FW, Posthumus MA, Dicke M
  Title
Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.
  Journal
Plant Physiol 121:173-80 (1999)
Reference
3  [PMID:10805454]
  Authors
Degenhardt J, Gershenzon J
  Title
Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis.
  Journal
Planta 210:815-22 (2000)
DOI:10.1007/s004250050684
Reference
4  [PMID:17924138]
  Authors
Arimura G, Garms S, Maffei M, Bossi S, Schulze B, Leitner M, Mithofer A, Boland W
  Title
Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of  jasmonate, ethylene and calcium signaling.
  Journal
Planta 227:453-64 (2008)
DOI:10.1007/s00425-007-0631-y
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.48
IUBMB Enzyme Nomenclature: 4.2.3.48
ExPASy - ENZYME nomenclature database: 4.2.3.48
BRENDA, the Enzyme Database: 4.2.3.48

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