KEGG   ENZYME: 4.2.3.69Help
Entry
EC 4.2.3.69                 Enzyme                                 

Name
(+)-alpha-barbatene synthase;
AtBS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-alpha-barbatene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-alpha-barbatene + diphosphate [RN:R09614]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-alpha-barbatene [CPD:C19740];
diphosphate [CPD:C00013]
Comment
The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% alpha-barbatene, 17.8% thujopsene (cf. EC 4.2.3.79, thujopsene synthase) and 9.9% beta-chamigrene (cf. EC 4.2.3.78, beta-chamigrene synthase) [1] plus traces of other sesquiterpenoids [2].
History
EC 4.2.3.69 created 2011, modified 2012
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15799  (+)-alpha-barbatene/beta-chamigrene/thujopsene synthase
Genes
ATH: AT5G44630
ALY: ARALYDRAFT_330931 ARALYDRAFT_683653
CRB: 17875170 17875197 17876640
CSAT: 104771640
EUS: EUTSA_v10001108mg EUTSA_v10001148mg EUTSA_v10001228mg
BRP: 103845828 103848456 103863851
BNA: 106371933 106449519
BOE: 106316964 106325935
Taxonomy
Reference
1  [PMID:15965019]
  Authors
Wu S, Schoenbeck MA, Greenhagen BT, Takahashi S, Lee S, Coates RM, Chappell J
  Title
Surrogate splicing for functional analysis of sesquiterpene synthase genes.
  Journal
Plant Physiol 138:1322-33 (2005)
DOI:10.1104/pp.105.059386
  Sequence
[ath:AT5G44630]
Reference
2  [PMID:15918888]
  Authors
Tholl D, Chen F, Petri J, Gershenzon J, Pichersky E
  Title
Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers.
  Journal
Plant J 42:757-71 (2005)
DOI:10.1111/j.1365-313X.2005.02417.x
  Sequence
[ath:AT5G44630]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.69
IUBMB Enzyme Nomenclature: 4.2.3.69
ExPASy - ENZYME nomenclature database: 4.2.3.69
BRENDA, the Enzyme Database: 4.2.3.69

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