KEGG   ENZYME: 4.2.3.72Help
Entry
EC 4.2.3.72                 Enzyme                                 

Name
alpha-gurjunene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-alpha-gurjunene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (-)-alpha-gurjunene + diphosphate [RN:R09606]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(-)-alpha-gurjunene [CPD:C19734];
diphosphate [CPD:C00013]
Comment
Initial cyclization probably gives biyclogermacrene in an enzyme bound form which is not released to the medium. The enzyme from Solidago canadensis also forms a small amount of (+)-gamma-gurjunene [1].
History
EC 4.2.3.72 created 2011
Reference
1  [PMID:10190971]
  Authors
Schmidt CO, Bouwmeester HJ, Bulow N, Konig WA
  Title
Isolation, characterization, and mechanistic studies of (-)-alpha-gurjunene synthase from Solidago canadensis.
  Journal
Arch Biochem Biophys 364:167-77 (1999)
DOI:10.1006/abbi.1999.1122
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.72
IUBMB Enzyme Nomenclature: 4.2.3.72
ExPASy - ENZYME nomenclature database: 4.2.3.72
BRENDA, the Enzyme Database: 4.2.3.72

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