KEGG   ENZYME: 4.2.3.79Help
Entry
EC 4.2.3.79                 Enzyme                                 

Name
thujopsene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl diphosphate lyase (cyclizing, (+)-thujopsene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate [RN:R10599]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(+)-thujopsene [CPD:C20724];
diphosphate [CPD:C00013]
Comment
The recombinant enzyme from the plant Arabidopsis thaliana produces 27.3% (+)-alpha-barbatene, 17.8% (+)-thujopsene and 9.9% (+)-beta-chamigrene [1] plus traces of other sesquiterpenoids [2]. See EC 4.2.3.69 (+)-alpha-barbatene synthase, and EC 4.2.3.78 beta-chamigrene synthase.
History
EC 4.2.3.79 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15799  (+)-alpha-barbatene/beta-chamigrene/thujopsene synthase
Genes
ATH: AT5G44630
ALY: ARALYDRAFT_330931 ARALYDRAFT_683653
CRB: 17875170 17875197 17876640
CSAT: 104771640
EUS: EUTSA_v10001108mg EUTSA_v10001148mg EUTSA_v10001228mg
BRP: 103845828 103848456 103863851
BNA: 106371933 106449519
BOE: 106316964 106325935
Taxonomy
Reference
1  [PMID:15965019]
  Authors
Wu S, Schoenbeck MA, Greenhagen BT, Takahashi S, Lee S, Coates RM, Chappell J
  Title
Surrogate splicing for functional analysis of sesquiterpene synthase genes.
  Journal
Plant Physiol 138:1322-33 (2005)
DOI:10.1104/pp.105.059386
  Sequence
[ath:AT5G44630]
Reference
2  [PMID:15918888]
  Authors
Tholl D, Chen F, Petri J, Gershenzon J, Pichersky E
  Title
Two sesquiterpene synthases are responsible for the complex mixture of sesquiterpenes emitted from Arabidopsis flowers.
  Journal
Plant J 42:757-71 (2005)
DOI:10.1111/j.1365-313X.2005.02417.x
  Sequence
[ath:AT5G44630]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.79
IUBMB Enzyme Nomenclature: 4.2.3.79
ExPASy - ENZYME nomenclature database: 4.2.3.79
BRENDA, the Enzyme Database: 4.2.3.79

DBGET integrated database retrieval system